tropicalpalmtree Posted October 24, 2020 Report Share Posted October 24, 2020 does anyone know anything about this protein and its effect on neurogenesis? i find it incredibly hard to understand the complicated research literature, so i'm not sure if this is flogging a dead horse. Its regulation seems to be a key in several neurological conditions. Again i'm not sure what i am really reading, i just hope this could be a lead to something in depth. I hope someone can pop up and explain how this system works. thanks Link to comment Share on other sites More sharing options...
SS1 Posted October 25, 2020 Report Share Posted October 25, 2020 dephosporylation and phosphorylation (adding or removing a phosphate acts as an on/off switch; for some proteins its "on" others "off" and vice versa.... It's like a cascade of events, usually another protein known as a kinase would add the phosphate group, one the phosphate is added, the complex would work to stimulate something else (could be transcriptional changes, apoptosis, etc....) somewhere else along the cascade/pathway) From what I gather, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381966/, it appears that if this protein is phosphorylated, it is inhibited. Dephosphorylated, it is activated. Although, I'm still trying to figure out which is good and which is bad, the dephosporylation or the phosphorylation. In any case, its just a theory, there are so many theories for so many conditions/diseases. I would be curious to here about exogenous substances that could affect its modulation, from that article it seems to play a role in epilepsy, neuropathic pain, and spasticity, conditions. Has anyone tried to explain it to you? - I'd be interested in hearing more about it. Link to comment Share on other sites More sharing options...
tropicalpalmtree Posted October 25, 2020 Author Report Share Posted October 25, 2020 4 hours ago, SS1 said: dephosporylation and phosphorylation (adding or removing a phosphate acts as an on/off switch; for some proteins its "on" others "off" and vice versa.... It's like a cascade of events, usually another protein known as a kinase would add the phosphate group, one the phosphate is added, the complex would work to stimulate something else (could be transcriptional changes, apoptosis, etc....) somewhere else along the cascade/pathway) From what I gather, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381966/, it appears that if this protein is phosphorylated, it is inhibited. Dephosphorylated, it is activated. Although, I'm still trying to figure out which is good and which is bad, the dephosporylation or the phosphorylation. In any case, its just a theory, there are so many theories for so many conditions/diseases. I would be curious to here about exogenous substances that could affect its modulation, from that article it seems to play a role in epilepsy, neuropathic pain, and spasticity, conditions. Has anyone tried to explain it to you? - I'd be interested in hearing more about it. Not yet man, but i have bought some Quercetin supplement which is a KCC2 activator. There are stronger drugs i've seen mentioned, one of particular interest to me was CLP-290, a novel prodrug which was the only drug listed on a research document as being revolutionary for KCC2 modulation! have a look on google, it may be of some interest. Link to comment Share on other sites More sharing options...
tropicalpalmtree Posted October 25, 2020 Author Report Share Posted October 25, 2020 i really hope i find someone that can decipher it all, i know its medical text and needs to be written in such a way, but its infuriating how complicated it all is. If only there were a google translate into layman's terms Link to comment Share on other sites More sharing options...
tropicalpalmtree Posted October 25, 2020 Author Report Share Posted October 25, 2020 https://www.mdpi.com/2073-4409/9/1/240/htm Link to comment Share on other sites More sharing options...
tropicalpalmtree Posted October 25, 2020 Author Report Share Posted October 25, 2020 https://www.cell.com/cell-reports/pdf/S2211-1247(19)30759-4.pdf Link to comment Share on other sites More sharing options...
tropicalpalmtree Posted October 26, 2020 Author Report Share Posted October 26, 2020 https://www.genengnews.com/topics/drug-discovery/paralyzed-mice-walk-following-drug-therapy/ this is pretty amazing with CLP-290 KCC2 manipulation, its method of action seems very encouraging for hppd Link to comment Share on other sites More sharing options...
tropicalpalmtree Posted October 26, 2020 Author Report Share Posted October 26, 2020 Just for information sake, i have purchased both resveratrol & quercetin to try on a 3 month basis, resveratrol in particular was indentified as a potent KCC2 modulator by the whitehead institute of biomedical research, alongside several other compounds. I have purchased 500mg/day capsules for both. Link to comment Share on other sites More sharing options...
SomebodySomewhere Posted October 26, 2020 Report Share Posted October 26, 2020 Use caution when using yourself as a guinea pig. I think you should research this more until you have a much better understanding before trying such medications. Just my two cents. Link to comment Share on other sites More sharing options...
tropicalpalmtree Posted October 29, 2020 Author Report Share Posted October 29, 2020 The resveratrol and quercetin are widely used supplements and have some safety profile so it'll be okay. If i can get hold of a specialist who knows a thing or two about CLP-290 though i would be enquiring in depth about its possible use for visual disturbances, i would be worried however taking this drug without prior information due to its obscurity. Link to comment Share on other sites More sharing options...
tropicalpalmtree Posted October 29, 2020 Author Report Share Posted October 29, 2020 and it costs a shit ton of money to buy, i mean a 30 day dose would be in the 10s of thousands of pounds/dollars Link to comment Share on other sites More sharing options...
SomebodySomewhere Posted October 29, 2020 Report Share Posted October 29, 2020 I understand the point you're making, the point I was making wasn't their safety profile, it had more to do with whether or not it would be safe in terms of HPPD. By your own admission, the subject is confusing, and it is to me too. I'm just saying maybe learn about the mechanism of action more thoroughly. Just because a drug is "safe" for most doesn't mean that's true for not increasing HPPD symptoms. Take SSRI's for example. Their effectiveness is questionable, but they're mostly regarded as safe....unless you have HPPD, in which case it can permenatly make your visual symptoms worse. I'm not trying to be disrespectful, I'm just promoting caution, it would suck if you took something for HPPD thinking it would help and then your symptoms got worse. That's all I'm getting at. Link to comment Share on other sites More sharing options...
tropicalpalmtree Posted October 29, 2020 Author Report Share Posted October 29, 2020 No disrespect at all, just getting ideas out there mate! Give this a look, its an old post but shows some promise. https://www.shroomery.org/forums/showflat.php/Number/15506267 I have started taking the resveratrol today, i will try for a few weeks, if its no good its another idea for the recycle bin 1 Link to comment Share on other sites More sharing options...
SomebodySomewhere Posted October 31, 2020 Report Share Posted October 31, 2020 Fair enough, I wish you success. Link to comment Share on other sites More sharing options...
SomebodySomewhere Posted November 13, 2020 Report Share Posted November 13, 2020 Update? It's been almost two weeks, I'm curious how this has worked for you. Link to comment Share on other sites More sharing options...
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