So, quick for introduction to my background in regards of HPPD, I have done a whole bunch of drugs before and I already had HPPD in a major developement and tried to manage it with certain forms of therapy and by giving it aome conciouss time... my constant symptoms when it was the best were tracers and that a part of my concioussess is in the spirit world which is very fine with me.
I pretty much had trust in DMT and Salvia (I don´t know why I trusted Salvia I only tryed it a few times before and one time it even scared me, with that I have to mention that I am used to trip hard and that it is hard to scare me in this sense )
To the topic... about 26h ago I tripped hard on salvia while I was on Paracetamol ( stupidity is big in this one because I forgot that I was taking Paracetamol because I took it as medication for my cold, knowing that Paracetamol has some sort of not fully researched effect on opioid eceptor and the fact that Salvinorin-a bind onto kappa-opioid receptors I propably wouldn´t have done the salvia)
After the trip I instantly wrote down my experience and while writing it down I started this feeling in my body arise, it was a combination between the HPPD I got from a 2cb x MDMA x Methamphetamine x Cannabis and the HPPD I got from a painfull experience with 5HTP and LSD just mixed into this salvia dissociation and trip
I slept hours longer than I usually do and woke up very dissociated
The dissociation is my main problem with this case of HPPD because it is not only like depersonalization/dissociation-syndrome it has it´s very own vibe ( like every HPPD) ... I just never had HPPD from a dissociative psychedelic I guess^^
other symptoms include: very strong enhancement of colours ( even stronger that it was with the LSD HPPD) ,constant contact/concioussness with/about these imagined/normally unperceived entities that arise when tripping hard on salvia, also I don´t have small visuals in my visual field like specific tracers for this HPPD or swirls or anything but my whole vision is moving as one most of the time when it is weaker ( as if I knew the world was spinning) when it gets worse I can´t see sharply and more complex geometric patterns are in my whole visual field.
I hope someone here can help me or that I can at least find some kind souls to share a path together
much love and light
First and foremost; I wish I could put this all coherently in an elaborate article like I did with Coluracetam, however my current state does not allow for that, so forgive me if this all seems a bit vague or wishy-washy.
This is a substance I've been wanting to try for months now.
Basically what it is, is an orally active selective long and fast acting (~2 weeks) potent kappa opioid receptor (KOR) antagonist. Say that three times fast.
The KOR is implicated in many things. Salvia Divinorum (more specifically, its active agent Salvinorin A), which I'm sure most of us are acquainted with, is a KOR agonist. So is Ketamine (see here a study with both aforementioned and JDTic).
These both (as well as all KOR agonists) known to induce a state of dissociation, depersonalization, derealization, anxiety, cognitive impairment, as well as hallucinations/visual distortions, and perhaps some others nuisances I'm forgetting.
Dynorphin is the endogenous KOR agonist, which appears to increase in levels under circumstances of stress and depression (see wiki), and also blocks glutamate release. Glutamate is also implicated in DP/DR as recently discussed, moreover it's the precursor to GABA, hence hypoglutamatergia is no fun. Furthermore, trying to agonize NMDA receptors for instance, would be kind of like mopping the floor with the faucet running. Though, as a side note, NRX-1074 (GLYX-13 derivative) would be really cool to try.
Ok well.. I don't seem to be good at tying up the loose ends here, but in any case it seems to me to have a high chance of abolishing dissociative symptoms. Oh yes, Naloxone and Naltrexone have been used to treat DP, the former of which completely abolished it in several individuals, however Naloxone is unsustainable.
JDTic seems to be relatively safe.. some concerns about 2/14 individuals having a transient heart arrhythmia or something benign like that, which is why they halted studies (protocol I guess).
I'll try to add more later, but if you've any questions, please ask.
This stuff is not available yet. I know many of you, like myself, are very willing to experiment if it's worth a shot, and this one most certainly is. There's not a group buy yet, but currently there are already 16 people interested in doing one. If you want to be a part of the group buy, and for far more elaborate discussion (and a lot of interesting articles), check out the Longecity thread. Also, for the only user review in the world, check out jdtic.com (bear in mind, this person did not suffer from any dissociative issues).
I get static pretty bad and the best way I can describe it is being somewhere between what I see and my thoughts. Along with static I have been seeing trippy stuff in this same plane of consciousness. Its like hallucinations that seem to fall short of reaching into my vision. Its like little pixels in my static are arranged into pictures that I can see overlapping my normal eyesight. I also feel like afterimages fit in this same place. I kind of think it is intertwined with my DP/DR, Its like I get so far dissociated from myself.
These thoughts and visions are so powerful and out of my control that it can be pretty scary and overwhelming at times, but it really makes me wonder about the insane potential of the human brain.