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Hallucinogen Persisting Perception Disorder (HPPD) Support Forum
Tigress7

HPPD for 48 years

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Hi I haven't been on this forum for 4 years!!! Long time. Just want to say I've had HPPD for 48 years.....and I learnt to live with it!!! Grateful if anyone could let me know if there has been any new research into the condition please? There still seems to be an shocking amount of ignorance about it. Thx.

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Damn 48 years.... That's some time eh 😂.

Well there have been many speculations like always when it comes to HPPD but AFAIK, no progress so far.

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Mmmm very bad indeed. I tried to explain HPPD to my doctor recently, he totally discounted its existence. I was in a very bad state with (what I know now to be HPPD), when I was 16 in 1970   No doctor, specialist, psychiatrist etc. believed me, and I was made to feel like a total maniac. Very bad times. But I survived and learned to live with it. I hate  of think others going through that nightmare because of ignorance. Heigh ho.

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On 11/28/2018 at 6:39 PM, Tigress7 said:

Mmmm very bad indeed. I tried to explain HPPD to my doctor recently, he totally discounted its existence. I was in a very bad state with (what I know now to be HPPD), when I was 16 in 1970   No doctor, specialist, psychiatrist etc. believed me, and I was made to feel like a total maniac. Very bad times. But I survived and learned to live with it. I hate  of think others going through that nightmare because of ignorance. Heigh ho.

Hi Tigress, 

Here in Canada it's starting to become a somewhat known condition, in some places more than others. The addictions and mental health clinics are aware of it - and the psychiatrists at the clinics typically prescribe lamotrigine and clonidine in combination to treat it. 

At the university of Alberta hospital the head of the psychiatry department is actually seemingly well versed in the condition and had actually told me that my best bet with treating the condition would be to test out an atypical antipsychotic called pimavanserin. Unfortunately this antipsychotic is still brand new meaning that it costs roughly $28000 us dollars per year for treatment. 😆

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13 hours ago, jbalsa2 said:

Hi Tigress, 

Here in Canada it's starting to become a somewhat known condition, in some places more than others. The addictions and mental health clinics are aware of it - and the psychiatrists at the clinics typically prescribe lamotrigine and clonidine in combination to treat it. 

At the university of Alberta hospital the head of the psychiatry department is actually seemingly well versed in the condition and had actually told me that my best bet with treating the condition would be to test out an atypical antipsychotic called pimavanserin. Unfortunately this antipsychotic is still brand new meaning that it costs roughly $28000 us dollars per year for treatment. 😆

PharmacodynamicsEdit

Pimavanserin acts as an inverse agonist and antagonist at serotonin 5-HT2A [5]receptors with high binding affinity (Ki 0.087 nM) and at serotonin 5-HT2Creceptors with lower binding affinity (Ki 0.44 nM). Pimavanserin shows low binding to σ1 receptors (Ki 120 nM) and has no appreciable affinity (Ki>300 nM) to serotonin 5-HT2B, dopamine (including D2), muscarinic acetylcholinehistamine, or adrenergic receptors, or to calcium channels.[1][6]

Pimavanserin has a unique mechanism of action relative to other antipsychotics, behaving as a selective inverse agonist of the serotonin 5-HT2Areceptor, with 40-fold selectivity for this site over the 5-HT2C receptor and no significant affinity or activity at the 5-HT2B receptor or dopamine receptors.[2]

……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………

It’s like playing  Russian roulette . look at its mechanism of action . it is working on 5-ht2a which is responsible of visual phenomena . It’s known that visual cortex has a-lot of 5-ht2a receptor and activating or deactivating this receptor will play a rule in how you see things .In the end it’s your choice.you take the drug experiment or stay away till they make more studies on hppd .
Edited by subzero
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