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jbalsa2

Most commonly used medications

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Hey guys,

Have made this thread for the purpose of educating either newcomers, or people who don’t have the resources yet on the medications that are available and most commonly used to treat and augment the symptoms of HPPD. Feel free as well to post here and ask questions.

 

Lamotrigine (Lamictal):

https://en.m.wikipedia.org/wiki/Lamotrigine

Lamotrigine, sold under the brand name Lamictal, among others, is an anticonvulsant medication used to treat epilepsy and bipolar disorder. This medication can reduce the symptoms of HPPD, and in many instances have even cured HPPD completely.

Dosing:

Lamotrigine should be titrated up slowly, starting at 25mg per day, and increased roughly every week until a typical dose of 100-200mg per day is reached. Starting lamotrigine too quickly can result in a skin condition called Stevens-Johnson syndrome, which is a condition that affects the skin on your body. It’s important to follow this titration process as this skin reaction can be deadly.

Common Side Effects:

Common side effects of Lamotrigine include sleepiness, headache, vomiting, trouble with coordination, and rash. Speak to your doctor about which side effects to look out for, and make sure to report all side effects to your doctor in a timely basis.

Resources:

Here’s the link for the NCBI case study that was done on Lamotrigine and HPPD - this can come in particular handy if you’re looking for some support in getting your doctor to prescribe you lamotrigine.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736944/

 

Levetiracetam (Keppra):

https://en.m.wikipedia.org/wiki/Levetiracetam

Levetiracetam, sold under the brand name Keppra, among others, is an anticonvulsant medication used to treat epilepsy. This medication can reduce some of the symptoms of HPPD, primarily symptoms of depersonalizations and derealization, and in many instances has even cured HPPD completely.

Dosing:

Levetiracetam can carry with it some initial onset symptoms, such as increased irritability, and in some cases an increase in psychosis like symptoms. It should be started at the smallest dose - 250mg twice daily, and increased at a bi-weekly or monthly rate until the desired effect is reached. Most commonly effective doses of levetiracetam in patients with HPPD range from 500mg twice daily to 750 mg twice daily.

Common Side Effects:

The most common adverse side effects of levetiracetam include central nervous system effects such as somnolence, decreased energy, headache, dizziness, mood swings, and coordination difficulties. These symptoms often wear off within the first week to two weeks of therapy, but it is important to report all side effects to your doctor. It should also be noted that vitamin B supplements have been shown to augment some of these side effects effectively as well.

Resources:

Here’s the link for the cover and results page of the case study that was done on Levetiracetam and HPPD - this can come in particular handy if you’re looking for some support in getting your doctor to prescribe you levetiracetam.

https://www.scribd.com/document/138316970/keppra-evidencias-curativas

 

Clonazepam (Klonopin):

https://en.m.wikipedia.org/wiki/Clonazepam

Clonazepam, sold under the brand name Klonopin, among others, is a medication used to prevent and treat seizures, panic disorder, and other movement disorders. It is a tranquilizer of the benzodiazepine class. Clonazepam is by far the most effective treatment for HPPD sufferers, especially in the short term. Caution should be used when using this medication, as daily or recurrent use can lead to tolerance and dependency.

Dosing: 

Clonazepam dosages should typically be started at about a half milligram (0.5mg) and adjusted as necessary. It’s typically not recommended for someone to take more than 2.0 mg of clonazepam a day. Dosing, if done daily, should not be continued for a period of longer than 3 weeks, as tolerance can build up in this time frame. Some doctors prescribe doses of clonazepam to be used in a “per as needed” basis, meaning that the user can take a dosage of clonazepam 1-3 times per week to provide them with some relief while averting tolerance and dependency.

Common Side Effects:

Common adverse side effects from clonazepam can include a feeling of sedation, motor impairment, confusion, lack of motivation, and memory impairment. These side effects are typically rare if the dosage regime is started properly - at around 0.5 mg per day, with the risk of these side effects occurring increasing as the dosage of clonazepam is increased.

 

Thanks for reading guys, and as always, if you have any questions comments or concerns, please comment.

 

Edited by jbalsa2

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Great post, thanks.

Just to add to the clonazepam section.... Here is a system that I use which allows a lot of relief with minimal risk of addiction/tolerance (it's worked now for 10+ years).

I use a 4 days on, 3 days off benzo treatment with 14 days off every 3 months to further clean the system:

Clonazepam (1mg) - Thursday 6pm
Clonazepam (1mg) - Friday 9am
Clonazepam (1.5mg) - Saturday 9am
Clonazepam (1.5mg) - Sunday 9am

Please note that if I feel ok on any of these days and have no social situations, I often skip the dose that day. And, of course, you could pick and choose any days, but they need to be in blocks, eg, mon, tue, wed, thu.

This works for me, but tread carefully as these are crazy addictive drugs... Maybe try 3 on, 4 off first and never skip the 2 weeks off part. This is essential to test your tolerance and addiction.

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Thank you for the good information.

Sorry for the English, I write through Google translate =)

- Lamotrigine can be taken simultaneously with Levetiracetam (keppra)?

- Can Levetiracetam (keppra) be taken with antidepressants (SSRIs) at the same time?

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Just now, Vladchik22 said:

Thank you for the good information.

Sorry for the English, I write through Google translate ?

- Lamotrigine can be taken simultaneously with Levetiracetam (keppra)?

- Can Levetiracetam (keppra) be taken with antidepressants (SSRIs) at the same time?

Hey there vladchik,

 

If I were you I would try one or the other before combining them, they work somewhat on the same systems in the body so by combining them you may (or may not be) compromising some of their individual effects.

Levetiracetam can be taken simultaneously with SSRI's, although to be honest I've found SSRI's to have a negative impact on my hppd.

That's just me however, really it's about finding what works for you, for example I take Abilify with levetiracetam. This combination doesn't cause my symptoms to become worse, although I've heard other people curse abilify's effect on their HPPD.

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1 hour ago, Vladchik22 said:

There are cases when symptoms do not return after Keppra is canceled? Do I need to take Keppra on an ongoing basis (all life)?

Hi Vladchik,

I've read that some people completely lose symptoms even after stopping keppra, and I've read of an individual who says if he stops taking the keppra that the visuals come back.

 

If it were me taking keppra, and my visuals completely went away, what I would do is continue to take keppra for another year or two years after my visuals went away, and then slowly reduce my keppra dose to see if my visuals have gone away completley. 

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