"BPC-157 is a synthetic peptide that is being investigated for its regenerative effects. It shows high efficacy for rats suffering toxic or surgical trauma, but there is currently no evidence that it provides benefits for people."
I stumbled upon this peptide after browsing some websites and then I found reddit posts of users claiming that they cured their anhedonia. This substance does not mask symptoms like traditional drugs, but really has some sort of a healing mechanism that rapidly undoes damage from the dopamine system, with almost no side effects reported. This got my interest and I decided to try it out. Here are the results:
250mcg in the morning and 250mcg in the evening, administered with subcutaneous injections. So far I have used a total of 10mg in around 10 days, and I'm planning to do extra cycles in the future.
While injections offer the best bioavailability, it is reported that this substance is stable when taken oral. I cannot confirm this and I'd recommend to inject the substance, or use it sublingually (under the tongue). Subcutaneous injections are almost painless and you'll get used to it quickly.
I'm experiencing permanent benefits from this trial. In general I feel much calmer with myself and my mind is so much clearer. My sense of time has changed back to normal. It feels like the world around me is moving normal again and I can get more done. I'm even boring myself when I'm free. Before this trial I would be able to do a lot less in an hour and it felt like the time shifted faster, and it felt I couldn't get a hold of the world moving around me.
Cognitive functioning has improved a little, I mostly feel benefits from taking fish oil and I believe this substance has contributed to it Depersonalisation and derealisation has definitely improved. Most of the time, it doesn't even bother me and I feel more attached to myself My anhedonia has decreased, I didn't experience a huge improvement but it's still much better I feel generally less anxious - I haven't worried about my condition since My visuals have not changed in any way, but the substance helped me to handle them easier and they don't feel like a big annoyance anymore.
I did not experience any side effects, which is good. There is some research suggesting that it increases tolerance to amphetamine, but it hasn't been tested on humans.
I definitely recommend anyone with HPPD to try this substance. It might help you a lot with depersonalization and derealisation, as it did with mine.
By Bursting Aura
I have only done about 10 hours of research on this, which is not much. Ideally I would like a couple more weeks to wrap my head around something before I recommend it and I need time to see the long-term effects for me also. But I have a strong inclination to quickly get this information to the group, so perhaps this will help someone else suffering. Maybe this works, maybe it doesn't. I cannot recommend this as a cure, but I can only say this has helped me. However, I am not sure if it placebo. Anyways, I did an 18 hour fast and it helped with my HPPD.
I will keep the anecdote short, because anecdotes never matter. What really matters is science and peer-review. I did this short-fast because I saw someone on here mention in a success story of curing HPPD on a 3 day fast. Someone commenting suggesting that it has to do with "neurogenesis". I did research on neurogenesis and it happens throughout our lives, such as during exercise or sex, so it doesn’t seem very significant. But, I stumbled upon a term called "autophagy"
ah-ta-fa-gee. Researching this process gave me motivation to try a 18 hour fast. My HPPD since then has gotten better. On a scale of 1-10 my symptoms have been at a 5 since Saturday, when they usually average about 7 or 8. I am theorizing my symptoms decreased because fasting induces autophagy.
Here is Autophagy from an article . "Short-term fasting induces profound neuronal autophagy"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106288/ Autophagy is a key homeostatic mechanism whose physiological importance is reflected by its preservation throughout the eukaryotic phylogenetic tree, from yeast to mammals. In recent years, autophagy has been recognized as a crucial defense mechanism against malignancy, infection and neurodegenerative diseases
Here is another definition. "Autophagy: cellular and molecular mechanisms" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990190/ Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as eliminating intracellular pathogens. Thus, autophagy is generally thought of as a survival mechanism. Autophagy is strongly induced by starvation and is a key component of the adaptive response of cells and organisms to nutrient deprivation that promotes survival until nutrients become available again.
Stay with me here. But it pretty much takes out damaged cells from our brains and recycles them in the liver. This process is activated via fasting.
"Neuronal autophagy: going the distance to the axon." https://www.ncbi.nlm.nih.gov/pubmed/18000396/ Furthermore, our study implicates dysfunction of axonal autophagy as a potential mechanism underlying axonopathy, which is linked to neurodegeneration associated with numerous human neurological disorders
Let me know what you think, I am always prepared to be entirely wrong. There is no research on a link between autophagy and HPPD obviously. So I am assuming a causal relationship that bad neurons are the cause of HPPD.
Here are more articles. I am hoping someone can partner and help me with this.
"Disruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration" http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002906
"Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons." https://www.ncbi.nlm.nih.gov/pubmed/17332773/
I found 2 posts of anecdotal claims.
2013 bluelight.com post about fasting curing hppd. http://www.bluelight.org/vb/archive/index.php/t-688613.html
2017 Reddit.com hppd forum success story about fasting curing hppd https://www.reddit.com/r/HPPD/comments/6ybbcs/success_story/
You can do an easy 18-hour fast by not eating after dinner at 5pm, and then not eating until noon the next day. Make sure you are healthy and talk to your doctor. I would like a couple people to try this to see if this actually works. I am going to start another fast today and I will report back in a week or so. Hopefully it works.
Potential adverse effects for women. there are claims that fasting can cause missed periods. Also, unfortunately it seems autophagy is less profound with females. https://www.ncbi.nlm.nih.gov/pubmed/19036730/ In other words, the damaged neurons have a harder time dying off. For men, fasting will temporary lower testosterone. Do your own research and talk to your doctor.