• Similar Content

    • By Bursting Aura
      Some research I found on anti-depressants efficacy and comparisons with placebo. Worth a read.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/ 
       From Harvard
      Antidepressants and the Placebo Effect
      Even the small statistical difference between antidepressants and placebos may be an enhanced placebo effect, due to the fact that most patients and doctors in clinical trials successfully break blind. The serotonin theory is as close as any theory in the history of science to having been proved wrong. Instead of curing depression, popular antidepressants may induce a biological vulnerability making people more likely to become depressed in the future.

      The most commonly prescribed antidepressants are SSRIs, drugs that are supposed to selectively target the neurotransmitter serotonin. But there is another antidepressant that has a very different mode of action. It is called tianeptine, and it has been approved for prescription as an antidepressant by the French drug regulatory agency. Tianeptine is an SSRE, a selective serotonin reuptake enhancer. Instead of increasing the amount of serotonin in the brain, it is supposed to decrease it. If the theory that depression is caused by a deficiency of serotonin were correct, we would expect to make depression worse. But it doesn’t. In clinical trials comparing the effects of tianeptine to those of SSRIs and tricyclic antidepressants, 63% of patients show significant improvement (defined as a 50% reduction in symptoms), the same response rate that is found for SSRIs, NDRIs, and tricyclics, in this type of trial (Wagstaff, Ormrod, & Spencer, 2001). It simply does not matter what is in the medication – it might increase serotonin, decrease it, or have no effect on serotonin at all. The effect on depression is the same.
      What do you call pills, the effects of which are independent of their chemical composition? I call them “placebos.”
       
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592645/ 
      From Duke and Brown University
      Antidepressants versus placebo in major depression: an overview
      As of now, antidepressant clinical trials have an effect size of 0.30, which, although similar to the effects of treatments for many other chronic illnesses, such as hypertension, asthma and diabetes, is less than impressive.
       
      https://www.ncbi.nlm.nih.gov/pubmed/22147715 
      Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis.
      Meta-analyses and mixed-treatment comparisons of response to treatment and weighted mean differences were conducted on specific scales to rate depression. On the basis of 234 studies, no clinically relevant differences in efficacy or effectiveness were detected for the treatment of acute, continuation, and maintenance phases of MDD. 
       
       
    • By Bursting Aura
      Omega 3's are mentioned a lot for there importance for brain health. Vitamin D can also pass the blood-brain barrier, so it should be investigated for mental health also. I drove over some papers on vitamin D and depression since yesterday, so I will share some of those here. Depression impacts quality of life and it is usually implicated to be self-caused. According to science, depression can be biological, therefore depression is not always a lack of spiritual perspective or a case of "bad" vibes. My conclusion from these papers is that most cases of depression are very situational. Vitamin D deficiencies are not rare, and can potentially have a healing affect with some cases, similar to anti-depressants. The optimal ways to get vitamin D in my opinion, is sunshine and mushrooms. I would stay away from raw mushrooms due to carcinogens reported in the literature. heat destroys them though. https://www.ncbi.nlm.nih.gov/pubmed/2132000
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751336/
      Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
      "The efficacy of vitamin D supplementation in depression has raised lots of concern. Vitamin D is considered as a neurosteroid [56], and now it is attested that vitamin D metabolites can cross the blood–brain barrier [34]. Because of the widespread presence of vitamin D receptor in areas of the brain including the hippocampus which is associated with the development of depression [23], it could be speculated that there is a clinical effect of vitamin D on depression."
      https://www.ncbi.nlm.nih.gov/pubmed/26680471
      Vitamin D in anxiety and affective disorders.
      "Reduced levels of vitamin or its metabolites have been reported in various psychiatric disorders. Insufficient levels of vitamin D in depressive patients have been confirmed by many authors. Significantly lower levels of calcidiol (vitamin D) were found in men and women with depression as well as in age matched patients with anxiety disorders.
      https://www.ncbi.nlm.nih.gov/pubmed/25713056
      Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior.
      "Serotonin regulates a wide variety of brain functions and behaviors. Here, we synthesize previous findings that serotonin regulates executive function, sensory gating, and social behavior and that attention deficit hyperactivity disorder, bipolar disorder, schizophrenia, and impulsive behavior all share in common defects in these functions. It has remained unclear why supplementation with omega-3 fatty acids and vitamin D improve cognitive function and behavior in these brain disorder"
    • By justaman
      I took hppd about 2 months ago and ever since I’ve been very aware of what I’m seeing. Like at night when I’m in the car driving, I’m not sure if it’s been there before but street lights or any sort of light kinda has a glare to it, like very shiny and has like a glow to it. I’ve noticed that when I look at the moon. There’s another moon next to it but half of the size, like a glare. I suck at explaining but am I getting hppd or is all this normal? I’ve been stressing over This for a while now and I’m going to a psychologist to get checked out. 
       
      I forgot to mention that I only taken lsd once. I’ve only smoked weed before . 
    • By HDDeer
      Hey guys,
      My doctor prescribed me lamictal yesterday and as pretty much all of you know, it's one of the more highly regarded medication out there for this condition.
      My hppd is actually very bearable, the only time I struggle is when I'm alone in the house where the lsd trip happened, which leads me to a few questions.
      If I decide to take it, and my hppd gets better/worse/stays the same, if I stop taking it will I return to baseline? Has anyone else taken this med? 
    • By 801music
      So in the beginning  of hppd I had tremors just in my fingers but now it's kinda spread to my hands they shake pretty bad some nights , and also I get twitches in my head and scalp like in my lips and eyelids and forehead. Also been having muscle tension in my arms and chest. Is this just hppd and anxiety ?
Sign in to follow this  
Followers 0
HDDeer

How to take klonopin

7 posts in this topic

My doctor prescribed me 0.5 mg of klonopin to take when needed, how should i take it so it reduces visuals.

0

Share this post


Link to post
Share on other sites

Preferably in handfuls. Joking.  

WARNING: DO NOT TAKE IT LIKE THAT!!!!

 

Take it in small chips, to take the edge off.  If you have 0.5mg pills literally bite off a chip of it.  You don't want it to sedate you throughout the day though.  And I know people with HPPD are sensitive to all drugs for the most part. 

Leave the rest for before sleep.  Or if you don't need it for sleep, literally take it when needed. 

 

Note: the odd thing with Clonazepam (which is not the case for Lorazepam and Diazepam) is that it takes like an hour to kick in.  So you can see the deal with that:  you have some weird visuals, you take the Klonopin, you have to wait an hour and perhaps the Klonopin doesn't even tame the visuals. That being said Klonopin is a pretty damn safe drug (if not mixed with other things). 

Edited by mgrade
0

Share this post


Link to post
Share on other sites

I took 4mg of klono the first night, no affects followed the next day. Took 1mg a few days ago and had extreme rebound anxiety and paranoia the day after. I also took 4mg of lorazepam(ativan) a week prior to the 4mg of klonopin. Im not trying to step on anyones toes but i see the argument wether or not if benzos are addictive or a dependent, and if i had to choose id say dependent. I dont see how anyone would want to long term use with these. As a matter of fact id almost prefer not to take benzos. Ive read that in most cases whoever has taken klono has been extremely helpful to them, i for one am not an example. I wonder what that means in terms of my "hppd" 

0

Share this post


Link to post
Share on other sites

Damn man 4 mg? Starting out half a mg did the job for me now I pop a 1 whenever the anxiety becomes too much.

I'm surprised it didn't knock your ass out.

0

Share this post


Link to post
Share on other sites

If 4mg doesn;t work, klonopin isn;t for you.

4mg would put me to sleep too.

0

Share this post


Link to post
Share on other sites

4mg is 'a lot'.  But unless you have COPD or take it with opiates, alcohol or barbiturates, Klonopin in particular is a super-safe drug!  

 

Snap-back anxiety is the issue!  If you run out of a prescript, the withdrawal is terrrible!!!  

 

I think the OD facts are like this: you would have to take 4,000 mg (or 4 grams) of Klonopin to have a 1% chance of dying. 

 

That is 1000x of a 4mg dose.

 

I do not suggest this btw.   But the reality of the situation is it would probably cost $50,000-$100,000 in Klonopin to kill you. 

Edited by mgrade
0

Share this post


Link to post
Share on other sites

I actually suffered more from clonazepam than I did with HPPD. I self-medicated, and became an addict. Withdrawal was the worst 6 months of my life.

 

I hope it's going well, but I'd suggest keeping away from it if you possibly can. I'll never touch a benzo again.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
Sign in to follow this  
Followers 0