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Hallucinogen Persisting Perception Disorder (HPPD) Support Forum
Mike

Nuplazid, A new, novel medication, give it a look

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Want to just throw out there that if anybody hopefully tries the low dose antipsych and hits some kind of wall, that that shouldn't disqualify Nuplazid in any way seeing that it's something for the most part completely different.  At least with the antipsych deal, your taking such a low dose that your shouldn't be dealing with side effects.

Edited by Mike

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On ‎6‎/‎12‎/‎2017 at 8:26 PM, K.B.Fante said:

For what it's worth, I contacted the authors of the recent North Carolina study about whether they think HPPD could be a result of a permanent sealing of the lid on the seratonin receptor and one of them said he thinks its highly unlikely. In fact, he specifically said he thinks there's no way it's even possible. Instead, he suggested the visual cortex could have become "sensitized" given our visual disturbances and the fact this area of the brain has a high number of 5-HT2A receptors

He sorta sounded like he was just spitballing, but I guess it's something. Still doesn't tell us much. 

Most likely what has happened in the brain with people who experience HPPD. From the sensitivity to visual distortions meaning the brain is having a difficult time filtering out useless visual stimuli to the over thinking and anxiety ridden disorders people develop also to the DP/DR phenomenon all suggest that 5ht2a receptors were upregulated either during the drug experience or afterwards as a defense response by the brain to compensate for the chaotic conditions that hallucinogenic drugs produce.

 

On another note, I may take this to my doctor and, after having kinda given up looking for new medications to help me for 5 or so years, I may yet again take up and gauntlet and start trying stuff again as recently my HPPD has been getting the better of me and have been bringing me down,

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On 10/9/2018 at 8:48 AM, shaolinbomber said:

Most likely what has happened in the brain with people who experience HPPD. From the sensitivity to visual distortions meaning the brain is having a difficult time filtering out useless visual stimuli to the over thinking and anxiety ridden disorders people develop also to the DP/DR phenomenon all suggest that 5ht2a receptors were upregulated either during the drug experience or afterwards as a defense response by the brain to compensate for the chaotic conditions that hallucinogenic drugs produce.

 

On another note, I may take this to my doctor and, after having kinda given up looking for new medications to help me for 5 or so years, I may yet again take up and gauntlet and start trying stuff again as recently my HPPD has been getting the better of me and have been bringing me down,

This medication costs $28000 per year. Just a heads up. Good luck getting any form of financial funding unless you've been specifically diagnosed with psychosis due to Parkinson's.

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Yeah its stupid expensive, maybe if they approve it for other uses or something else comes along on as an inverse agonist on the 5ht2a receptor is approved for something else, til then, its the only one out there like it as far as I know.

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Hmmm i still don't get it. So the antagonists like olanzapine , risperidone block the receptorst while the inverse-agonists try to re-adjust restore the settings of the receptors to default? XD

Enlighten me

tried to to some reserach on this but brain fog and shor term memory problems fuck me up

 

Edited by HalluciSofos

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