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    • By Bursting Aura
      Some research I found on anti-depressants efficacy and comparisons with placebo. Worth a read.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/ 
       From Harvard
      Antidepressants and the Placebo Effect
      Even the small statistical difference between antidepressants and placebos may be an enhanced placebo effect, due to the fact that most patients and doctors in clinical trials successfully break blind. The serotonin theory is as close as any theory in the history of science to having been proved wrong. Instead of curing depression, popular antidepressants may induce a biological vulnerability making people more likely to become depressed in the future.

      The most commonly prescribed antidepressants are SSRIs, drugs that are supposed to selectively target the neurotransmitter serotonin. But there is another antidepressant that has a very different mode of action. It is called tianeptine, and it has been approved for prescription as an antidepressant by the French drug regulatory agency. Tianeptine is an SSRE, a selective serotonin reuptake enhancer. Instead of increasing the amount of serotonin in the brain, it is supposed to decrease it. If the theory that depression is caused by a deficiency of serotonin were correct, we would expect to make depression worse. But it doesn’t. In clinical trials comparing the effects of tianeptine to those of SSRIs and tricyclic antidepressants, 63% of patients show significant improvement (defined as a 50% reduction in symptoms), the same response rate that is found for SSRIs, NDRIs, and tricyclics, in this type of trial (Wagstaff, Ormrod, & Spencer, 2001). It simply does not matter what is in the medication – it might increase serotonin, decrease it, or have no effect on serotonin at all. The effect on depression is the same.
      What do you call pills, the effects of which are independent of their chemical composition? I call them “placebos.”
       
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592645/ 
      From Duke and Brown University
      Antidepressants versus placebo in major depression: an overview
      As of now, antidepressant clinical trials have an effect size of 0.30, which, although similar to the effects of treatments for many other chronic illnesses, such as hypertension, asthma and diabetes, is less than impressive.
       
      https://www.ncbi.nlm.nih.gov/pubmed/22147715 
      Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis.
      Meta-analyses and mixed-treatment comparisons of response to treatment and weighted mean differences were conducted on specific scales to rate depression. On the basis of 234 studies, no clinically relevant differences in efficacy or effectiveness were detected for the treatment of acute, continuation, and maintenance phases of MDD. 
       
       
    • By Bursting Aura
      Omega 3's are mentioned a lot for there importance for brain health. Vitamin D can also pass the blood-brain barrier, so it should be investigated for mental health also. I drove over some papers on vitamin D and depression since yesterday, so I will share some of those here. Depression impacts quality of life and it is usually implicated to be self-caused. According to science, depression can be biological, therefore depression is not always a lack of spiritual perspective or a case of "bad" vibes. My conclusion from these papers is that most cases of depression are very situational. Vitamin D deficiencies are not rare, and can potentially have a healing affect with some cases, similar to anti-depressants. The optimal ways to get vitamin D in my opinion, is sunshine and mushrooms. I would stay away from raw mushrooms due to carcinogens reported in the literature. heat destroys them though. https://www.ncbi.nlm.nih.gov/pubmed/2132000
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751336/
      Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
      "The efficacy of vitamin D supplementation in depression has raised lots of concern. Vitamin D is considered as a neurosteroid [56], and now it is attested that vitamin D metabolites can cross the blood–brain barrier [34]. Because of the widespread presence of vitamin D receptor in areas of the brain including the hippocampus which is associated with the development of depression [23], it could be speculated that there is a clinical effect of vitamin D on depression."
      https://www.ncbi.nlm.nih.gov/pubmed/26680471
      Vitamin D in anxiety and affective disorders.
      "Reduced levels of vitamin or its metabolites have been reported in various psychiatric disorders. Insufficient levels of vitamin D in depressive patients have been confirmed by many authors. Significantly lower levels of calcidiol (vitamin D) were found in men and women with depression as well as in age matched patients with anxiety disorders.
      https://www.ncbi.nlm.nih.gov/pubmed/25713056
      Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior.
      "Serotonin regulates a wide variety of brain functions and behaviors. Here, we synthesize previous findings that serotonin regulates executive function, sensory gating, and social behavior and that attention deficit hyperactivity disorder, bipolar disorder, schizophrenia, and impulsive behavior all share in common defects in these functions. It has remained unclear why supplementation with omega-3 fatty acids and vitamin D improve cognitive function and behavior in these brain disorder"
    • By justaman
      I took hppd about 2 months ago and ever since I’ve been very aware of what I’m seeing. Like at night when I’m in the car driving, I’m not sure if it’s been there before but street lights or any sort of light kinda has a glare to it, like very shiny and has like a glow to it. I’ve noticed that when I look at the moon. There’s another moon next to it but half of the size, like a glare. I suck at explaining but am I getting hppd or is all this normal? I’ve been stressing over This for a while now and I’m going to a psychologist to get checked out. 
       
      I forgot to mention that I only taken lsd once. I’ve only smoked weed before . 
    • By Kaleidoscope
      Hello Everyone! 
      Wow! I have only recently discovered that continuous flashbacks have a label! I have had HPPD since I was 12 years old. Now I am 60. I spent the school year dropping LSD, Psycibin, Mescaline, and Marijuana. One time I simply never came down. It intensified soon soon after. I knew of no one else who had this like I did! I was simply terrified! I only told my brother, not my parents. My biggest fear was that I would get uncontrollably higher. I had every symptom but the very worst was the feeling of not being fully present. The experience was like just arriving in my own body but realizing I had already been doing whatever it was, but not with full presence. Maybe this is "de-personalization"? I would explain it to various Doctors and Opthalmologists through the years and all I got was "hmm....."! So, I finally just learned to cope. Then about a year ago I found the name HPPD. The casebook description of symptoms were as if they had read my secret diary! I know that I was never diagnosed  or believed, but I know  what drugs I used and when the HPPD started. Now it has been 48 years!  Definitely some of the symtoms are not as vivid as in the beginning, however, if I get tired or in a conglomerated atmosphere there they are. I also think after so many years these just become part of your normal perception. For me, HPPD did not go away.
      How did I cope until now? I definitely quit any drug use immediately. I gravitated toward a simple Christian way of life, actually living with Old Order Amish at times, where I was not bombarded by electric stuff. I think those who have HPPD will seriously have to deal with sensory overload and seek out a peaceful existence on many levels.
      Live your life anyway. I raised 7 children, grandchildren and life goes on, just looking through Kaliedoscope eyes!
      Be healthy! Be smart and realize sometimes one stupid mistake done in youth can change your life forever! In my case, I just wanted to be cool in 1969! I really didn't realize the risks. How true it is that we reap what we so!
      I want to cry...that I lived my whole life with this and never found anyone else with this or knew even that it was recognized!
      The only report on flashbacks I ever heard of said that they think LSD creates new neural pathways in the brain.That was maybe 30 yrs ago!
      Wow! I am truly impressed  at my own  survival! 
      Trails, pulsating breathing walls, tinnitus, time slowing down, colors, everything. Even dialated pupils. Sigh. How exhausting at times! 
      It has helped me just to keep in mind that my own perception has been tweeked.My chemistry was altered.
      I would not wish this on anyone! But, if you have it, just live your life as peaceful as you can. Do everything you normally would do because your heightened perception maybe can be helpful in other unexpected ways.
      Don't do anymore drugs.
      Dont tell others who may not understand.
      We've been tricked by the devil's potions! 
      God bless us all!
       
       
       
    • By HDDeer
      Hey guys,
      My doctor prescribed me lamictal yesterday and as pretty much all of you know, it's one of the more highly regarded medication out there for this condition.
      My hppd is actually very bearable, the only time I struggle is when I'm alone in the house where the lsd trip happened, which leads me to a few questions.
      If I decide to take it, and my hppd gets better/worse/stays the same, if I stop taking it will I return to baseline? Has anyone else taken this med? 
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HDDeer

Bad acid trip

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Hi all, 19th of march this year i microdosed 3 tabs of acid(my second time doing lsd) after my trip i had a really bad time(felt like tv shows were attacking my insecurities, felt like something watching me, hallucinating a white demonic looking face in the centre of my eye) that has all subsided now, and i am now left with ghosting, visual snow, afterimages and very minor palinopsia. As far as dp/dr goes i no longer feel like a zombie when im in crowds but as long as ive been alive ive felt numb so i cant say i really "feel" things. Anyways, as far as progress goes im feeling pretty good about it. My paranoia is gone and i dont have a whole lot of anxiety. I do tend to have mood shifts an awful lot(between angry-neutral) ill get jolts of happiness but they never really last. My hppd i fine also comes with a weird type of pareidolia where if i look in my jeans i can see little tiny people with weird faces. I also have the ability to see reptiles and demons if i stare at floor with pattern long enough(which makes my visual snow worse, i think its kinda like colour shifts??) Im definitely open to the idea of being schizophrenic or bipolar(i do believe im bipolar tbh) i saw shadow people on my lsd trip. Anyways recently ive started taking the supplements:

NAC

OMEGA 3

LIONS MANE

L TYROSINE

GINKO BILOBA.

I am very interested in taking piracetam with choline as ive heard some good things but also some bad. My doctor prescribed me lexapro and seroquel but im not interested in taking those until at least up to or over a year. I will be trying to take keppra or lamotrigine after the 6th month mark. Anyways thats my story for the most part. I look forward to hearing your responses. 

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Be careful with taking too many supplements, especially if you're already on other pharmaceuticals. Often times even one supplement can make your symptoms worse, but combining a lot is almost guaranteed to exacerbate your symptoms to some degree. 

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36 minutes ago, K.B.Fante said:

Be careful with taking too many supplements, especially if you're already on other pharmaceuticals. Often times even one supplement can make your symptoms worse, but combining a lot is almost guaranteed to exacerbate your symptoms to some degree. 

I will be sure to look out for it. Today was my first day taking all of them and i actually had moments where i had no visual snow at and very little ghosting. Ive also noticed that it usually contributes to my mood as well. 

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"Looking at your jeans I can see ... "  This was one of my first symptoms.  I would see strange shapes and designs in my jeans.  It graduated to everything with a fine grain (sand, tar, etc) all the time.  I take that back, when I dream I don't hallucinate.  Yes, be careful with supplements.  I don't know why but this condition makes me very sensitive to them (or it's all in the head, not sure).  Needles to say, sobriety, especially from hallucinogenic chemicals (including thc) ,would be my advice.  I hope your symptoms subside.  I really do.

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9 hours ago, MadDoc said:

"Looking at your jeans I can see ... "  This was one of my first symptoms.  I would see strange shapes and designs in my jeans.  It graduated to everything with a fine grain (sand, tar, etc) all the time.  I take that back, when I dream I don't hallucinate.  Yes, be careful with supplements.  I don't know why but this condition makes me very sensitive to them (or it's all in the head, not sure).  Needles to say, sobriety, especially from hallucinogenic chemicals (including thc) ,would be my advice.  I hope your symptoms subside.  I really do.

Is that before you continued to do drugs or after? I got hppd from my last lsd trip but havent touched any hallucinogen or weed since. 

Edit: i will also say that there is a bathroom in my sisters house with swirling patterns and in that flooring i have 3 entity like figures burned into my head every time i look at the floor. 

Edited by HDDeer
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I had some visuals after my first trip but only when I smoked cannabis.  At first they were "isolated".  I'd see one or a group of strange shapes and then it would go away.  I remember seeing them on speaker covers, my jeans, carpets, etc. So, to answer your question, It was before my heavy psychedelics consumption.    

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10 minutes ago, MadDoc said:

I had some visuals after my first trip but only when I smoked cannabis.  At first they were "isolated".  I'd see one or a group of strange shapes and then it would go away.  I remember seeing them on speaker covers, my jeans, carpets, etc. So, to answer your question, It was before my heavy psychedelics consumption.    

Thx Doc! My drug days are definitely over. But im still able to see patterns in stuff if i allow my brain to recognize it. In a way i dont exactly see that as a bad thing other than the fact my mind is creative. I dont notice anything in trees or leaves though. But yes anything with swirls, wood grain or patterns on a wall my brain will make its own pattern. I do find that its going away. At the start of it all i could see it in my hands and in my bed covers. But after 40+ years i can imagine wanting a break. But just know the world is only as you percieve it. Just because you can see it and someone else cant doesnt mean its not there! 

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I realize my visuals aren't real and I've never been delusional.   At times they're wearing and at times entertaining.  It's just who I am and I don't worry about it much anymore.  The strange thing is that when I'm focused (driving, working, etc) I don't notice any visuals.  

It's good to hear that your symptoms have subsided some.  That's a really positive sign!

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8 hours ago, MadDoc said:

I realize my visuals aren't real and I've never been delusional.   At times they're wearing and at times entertaining.  It's just who I am and I don't worry about it much anymore.  The strange thing is that when I'm focused (driving, working, etc) I don't notice any visuals.  

It's good to hear that your symptoms have subsided some.  That's a really positive sign!

Do you have visual snow? 

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No visual snow.  The first place I heard about it was in this forum.  

A typical visual plays out as follows.  If I look at a road surface or a sidewalk I immediately see little loop like patterns defined by the different colored pebbles.  These start for morph into bigger loops and designs sort of like a paisley print.  If I stare at it long enough (30 seconds roughly) more complex objects form.  Oriental dragons is a common theme.  Sometimes strange animals, sometimes something unexpected.  It always happens and I can't make it stop.  However, it's not tied into my thinking.  My cognitive abilities are intact.  Sometimes it's not so apparen't other times it's very distracting.  The air in between what I'm seeing is usually clear but not always.  At times the designs include lines that extend through the air.  It's a hard thing to describe.  There are moments when I'll stare at something just to see what will happen.  Other times, I wish it would stop.  Thanks for "listening".  There aren't many places I can discuss this without being considered insane.

Edited by MadDoc
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