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    • By Bursting Aura
      Some research I found on anti-depressants efficacy and comparisons with placebo. Worth a read.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/ 
       From Harvard
      Antidepressants and the Placebo Effect
      Even the small statistical difference between antidepressants and placebos may be an enhanced placebo effect, due to the fact that most patients and doctors in clinical trials successfully break blind. The serotonin theory is as close as any theory in the history of science to having been proved wrong. Instead of curing depression, popular antidepressants may induce a biological vulnerability making people more likely to become depressed in the future.

      The most commonly prescribed antidepressants are SSRIs, drugs that are supposed to selectively target the neurotransmitter serotonin. But there is another antidepressant that has a very different mode of action. It is called tianeptine, and it has been approved for prescription as an antidepressant by the French drug regulatory agency. Tianeptine is an SSRE, a selective serotonin reuptake enhancer. Instead of increasing the amount of serotonin in the brain, it is supposed to decrease it. If the theory that depression is caused by a deficiency of serotonin were correct, we would expect to make depression worse. But it doesn’t. In clinical trials comparing the effects of tianeptine to those of SSRIs and tricyclic antidepressants, 63% of patients show significant improvement (defined as a 50% reduction in symptoms), the same response rate that is found for SSRIs, NDRIs, and tricyclics, in this type of trial (Wagstaff, Ormrod, & Spencer, 2001). It simply does not matter what is in the medication – it might increase serotonin, decrease it, or have no effect on serotonin at all. The effect on depression is the same.
      What do you call pills, the effects of which are independent of their chemical composition? I call them “placebos.”
       
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592645/ 
      From Duke and Brown University
      Antidepressants versus placebo in major depression: an overview
      As of now, antidepressant clinical trials have an effect size of 0.30, which, although similar to the effects of treatments for many other chronic illnesses, such as hypertension, asthma and diabetes, is less than impressive.
       
      https://www.ncbi.nlm.nih.gov/pubmed/22147715 
      Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis.
      Meta-analyses and mixed-treatment comparisons of response to treatment and weighted mean differences were conducted on specific scales to rate depression. On the basis of 234 studies, no clinically relevant differences in efficacy or effectiveness were detected for the treatment of acute, continuation, and maintenance phases of MDD. 
       
       
    • By Bursting Aura
      Omega 3's are mentioned a lot for there importance for brain health. Vitamin D can also pass the blood-brain barrier, so it should be investigated for mental health also. I drove over some papers on vitamin D and depression since yesterday, so I will share some of those here. Depression impacts quality of life and it is usually implicated to be self-caused. According to science, depression can be biological, therefore depression is not always a lack of spiritual perspective or a case of "bad" vibes. My conclusion from these papers is that most cases of depression are very situational. Vitamin D deficiencies are not rare, and can potentially have a healing affect with some cases, similar to anti-depressants. The optimal ways to get vitamin D in my opinion, is sunshine and mushrooms. I would stay away from raw mushrooms due to carcinogens reported in the literature. heat destroys them though. https://www.ncbi.nlm.nih.gov/pubmed/2132000
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751336/
      Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
      "The efficacy of vitamin D supplementation in depression has raised lots of concern. Vitamin D is considered as a neurosteroid [56], and now it is attested that vitamin D metabolites can cross the blood–brain barrier [34]. Because of the widespread presence of vitamin D receptor in areas of the brain including the hippocampus which is associated with the development of depression [23], it could be speculated that there is a clinical effect of vitamin D on depression."
      https://www.ncbi.nlm.nih.gov/pubmed/26680471
      Vitamin D in anxiety and affective disorders.
      "Reduced levels of vitamin or its metabolites have been reported in various psychiatric disorders. Insufficient levels of vitamin D in depressive patients have been confirmed by many authors. Significantly lower levels of calcidiol (vitamin D) were found in men and women with depression as well as in age matched patients with anxiety disorders.
      https://www.ncbi.nlm.nih.gov/pubmed/25713056
      Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior.
      "Serotonin regulates a wide variety of brain functions and behaviors. Here, we synthesize previous findings that serotonin regulates executive function, sensory gating, and social behavior and that attention deficit hyperactivity disorder, bipolar disorder, schizophrenia, and impulsive behavior all share in common defects in these functions. It has remained unclear why supplementation with omega-3 fatty acids and vitamin D improve cognitive function and behavior in these brain disorder"
    • By Andando
      I have had HPPD for 15 years, 
      I am much better now than when it started, I have tried so many natural and psychological techniques that I feel its the right time to test if certain Medical treatment could work.
      My main symptoms are now anxiety, depression, heavy brainfog, visual snow, problems reading - writing, focusing and depersonalisation sometimes.
      I have found a neurologist in the city of Barcelona where I live, and I will like to ask you guys for a favour before I meet him:
      is there is an order for which meds are to be tried first?
      which meds in your view have been the most successful in treating some symptoms?.is there a page with these things online?
      I tried a low dose of diazepam and the day after my symptoms where very high again so I stopped, same thing with an antidepressant.
      Having said all of this I will like to share some hopeful news too:  I have been fortunate to have had days with almost no symptoms, have traveled extensively, managed to finish my BA in fine arts, lived in various countries, got my drivers license, can now read (even though i get confused sometimes), I can hold conversations much better (less DP), at the beginning of this disorder my life was very very miserable now its a lot better.
      Thank you for reading.
       
    • By justaman
      I took hppd about 2 months ago and ever since I’ve been very aware of what I’m seeing. Like at night when I’m in the car driving, I’m not sure if it’s been there before but street lights or any sort of light kinda has a glare to it, like very shiny and has like a glow to it. I’ve noticed that when I look at the moon. There’s another moon next to it but half of the size, like a glare. I suck at explaining but am I getting hppd or is all this normal? I’ve been stressing over This for a while now and I’m going to a psychologist to get checked out. 
       
      I forgot to mention that I only taken lsd once. I’ve only smoked weed before . 
Cal_HPPD

Can anyone relate to these symptoms? Confirm my diagnosis?

3 posts in this topic

         I've had what i believe to be HPPD for about 3 years now, after a slew of mushroom trips around age 15. I cant pinpoint exactly when i started showing symptoms because i feel they came on very subtly and gradually, and after 3 long years, seem to still be worsening. I remember the first thing i noticed was a light visual snow or static fuzziness that i could only see at night or in dark places, then slowly it started becoming more noticeable with time. I would start then seeing the visual snow or static fuzziness during the day time, most noticeably when looking at something solid and with minimal detail, like a wall or a cloudless sky. The trend of it getting worse continued, i would start getting progressively stronger tracer vision, beginning with things like car and street lights at night. As before, over a few months these symptoms began to translate over to during the day time. Now its to the point where i get tracers as simply as slowly running my hand past my eyes, and the visual snow is strong like what you see on a television that isn't getting any signal. The visual snow even forms into psychedelic shapes sometimes, spirals and things that look like your phone screen when there is grease on it. This is most often at night and in the morning when i am tired, but is not limited to that. When i close my eyes all i can see are these weird colorful randomly moving shapes and images. If i do something like read a book or read something on my computer, when i close my eyes i just see randomly occurring letters and numbers, and this lasts for 15 minutes or so. Florescent lights make all the symptoms particularly strong, so you can imagine school was quite difficult.There are halos around almost everything i look at, especially letters and numbers. My memory and ability to think straight and clearly feels like its degenerating. I cant focus on anything, and having ADHD doesn't help aha. I've also dealt with things anxiety and depression and depersonalization and severe migraines so that cant be helping. Ive completely stopped all substances except alcohol, the occasional cigarette and the occasional joint to help deal with the stress. But i used all 3 of these things and more up until about a year ago. none of it was hallucinogenic though

        My point of posting this was not to for attention or plead my case on how hard it is to live with. I know there are people on here that have it worse than i do, but i rather just posted this to see if anybody can relate to my experience so far and has dealt with a similar situation. I haven't read many stories of people with HPPD that seems to be progressively getting worse, so i'm just seeing if someone can confirm its HPPD and not something else. I've been to countless doctors across Toronto and most of them have even heard of HPPD, let alone how to treat it haha, so i kind of gave up on the medical route. Ive had brain scans that all came back negative for anything so HPPD seems to be the only thing i have found that matches my symptoms. Its a scary thought thinking about what it might amount to if the symptoms keep exaggerating like they are doing now. Its only been three years so its pretty debilitating thinking about what it might be like after 10...20...years etc if it doesnt stop, as i only just turned 18 aha. This is my first post so any replies or support really helps, thanks.  -Cal

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Man, I dunno, sounds like you have some pretty bad symptoms. My HPPD was indescribable the first three to six months it was so bad, but I've gotten much better over the course of 21 months.

There's definitely a lot of stories about people getting progressively worse, so don't feel like you're alone on that front. My first advice would be to stop all drugs -- including caffeine, cigarettes and alcohol -- and see how you feel then. I've noticed an increasing number of cases where people have talked about alcohol making their symptoms worse even after it's exited their system, so I think there's a clear connection there. 

I really firmly believe if your symptoms are getting worse it's because there's something your consuming that's causing them to get worse. Once you abstain from drugs for a while you also might try switching up your diet. I know people get tired of me saying this but eating healthy (eliminating gluten, added sugar, excess dairy, and eating more of a paleo-mediterranean diet) might really help you out. It's worked for me. 

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>> The visual snow even forms into psychedelic shapes sometimes, spirals  ....

That sound similar to what I deal with.  I agree with K.D. taking a break might be a good idea just to see how you feel after a while.  I noticed similar symptoms when I was using (I was 14) but I continued to use psychedelics for another six years unfortunately.  I wish I had stopped right after the symptoms started.  That was back in the early 70s and nobody had ever heard of HPPD.  We were always afraid of "flashbacks" which never seemed to happen to anyone so I figured that continuing to use wasn't going to have an impact.

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