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Hallucinogen Persisting Perception Disorder (HPPD) Support Forum
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Haloperidol: need some advice

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Should I just avoid it and not take it?


My doc prescribed it because, as some of you may know, I have/am developing a psychotic disorder. 


I know it's primarily a dopamine antagonist and that HPPD seems to primarily be linked to the serotonin system. But as I've read on this forum and elsewhere, anti-psychotics should be avoided.


However, it seems like most people are talking about atypical anti-psychotics, which are both dopamine and serotonin antagonists, rather than typical anti-psychotics like haloperidol.


In my research, I haven't found many reports of using haloperidol to treat HPPD or using haloperidol to treat comorbid psychosis with HPPD. I've read the Moskowitz study, but in that cases it was used to treat flashbacks, not necessarily HPPD since before the diagnostic criteria were introduced into the DSM, flashbacks and HPPD were lumped together, so it isn't exactly clear whether they were treating flashbacks or HPPD.


I haven't seen many anecdotal reports either. The ones I have seen are mixed in that they say it either 1) helps, 2) does nothing, or 3) makes HPPD worse. What's disappointing about these anecdotal reports is that the authors don't include much information such as their particular dose, other comorbid disorders, hallucinogen that most likely caused their HPPD, other medications and dosage, etc. They just say whether it worked, didn't, or made things worse.


So, if there is anyone on this forum that has tried haloperidol and is willing to give a detailed description of their experience, I would very much appreciate it if you could post in this thread and help me determine whether I should try this med or not.


I obviously want to treat the psychotic symptoms, but at this point, my HPPD is what's causing me the most distress, worsening it simply for the sake of treating another disorder that isn't causing me much distress would just push me over the edge.


Here's my detailed report:

  • Comorbid disorders: Major depressive disorder, panic disorder, schizophrenia/psychosis NOS
  • Current psychiatric medications: 1mg clonazepam twice daily (helps with anxiety), 100mg lamotrigine twice daily (some improvement of visual symptoms)
  • Current non-psychiatric medications: Albuterol, 2 puffs as needed for asthma
  • Past medications tried for HPPD/other disorders: Escitalopram (stopped at 2.5mg once daily, made HPPD worse, 3 day trial), risperidone (stopped at .5mg twice daily, made HPPD worse, only lasted 1 day) [NOTE: These were taken in roughly the same time period]
  • Drug(s)/hallucinogen(s) most likely to have caused HPPD: DPH (diphenhydramine aka Benadryl), used on a nightly basis for ~2 years at doses of 150mg+, potentially MDMA (only ever tried once), potentially THC (only ever tried once, had a severe panic attack)
  • Proposed dose of haloperidol: 2mg once daily tapering up to 5mg once daily
  • Other proposed medications/supportive agents: Benztropine 1mg twice daily to control EPS of haloperidol

The main reason I want a detailed report is so I can make a better judgement as to whether it will worsen it or not and thus whether to take it or not. The detailed report gives me an indication of what the underlying cause is and what system is affected in particular. Knowing the drug that caused it and what drugs made it worse/better gives me an idea of the neurotransmitter system that's affected the most by your HPPD. In my case, it seems like mine is primarily linked to the serotonin system and acetylcholine system considering that my drug of choice was DPH, a well known anticholinergic, and that serotonin antagonists made it worse. In particular, for me, it seems like I likely have an acetylcholine deficiency and something funky with my serotonin system (potentially a sort of serotonin toxicity since risperidone blocks serotonin from being absorbed and escitalopram increases it, thus highly increased levels of serotonin).


Thanks in advance



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You probably shouldn't. I have been seeing a lot of people saying that medications are making their HPPD worse. I'm trying to recover drug free and hopefully I don't get desperate to the point where I do take meds

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I wouldn't touch anti psychs. Word of mouth is they make good significantly worse. Some people report feeling like they are in the middle of a bad trip when taking them. Although if you do, and it gets much worse, you might find that drugs like Sinemet help you a lot.

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Apparently people on the visual snow board have used haloperidol to treat visual snow, I would give it a try if it gets bad you just stop taking it

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I have used anti-psyg for 3 years they kill your sexdrive and gain weight its terrible and i had more hallunisations and come off its hard once you take it more then 1 month and i think its make hppd worse there are some benefits buth the side effects are terrible its took me 6 months to geth use to it

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