• Similar Content

    • By Bursting Aura
      Some research I found on anti-depressants efficacy and comparisons with placebo. Worth a read.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/ 
       From Harvard
      Antidepressants and the Placebo Effect
      Even the small statistical difference between antidepressants and placebos may be an enhanced placebo effect, due to the fact that most patients and doctors in clinical trials successfully break blind. The serotonin theory is as close as any theory in the history of science to having been proved wrong. Instead of curing depression, popular antidepressants may induce a biological vulnerability making people more likely to become depressed in the future.

      The most commonly prescribed antidepressants are SSRIs, drugs that are supposed to selectively target the neurotransmitter serotonin. But there is another antidepressant that has a very different mode of action. It is called tianeptine, and it has been approved for prescription as an antidepressant by the French drug regulatory agency. Tianeptine is an SSRE, a selective serotonin reuptake enhancer. Instead of increasing the amount of serotonin in the brain, it is supposed to decrease it. If the theory that depression is caused by a deficiency of serotonin were correct, we would expect to make depression worse. But it doesn’t. In clinical trials comparing the effects of tianeptine to those of SSRIs and tricyclic antidepressants, 63% of patients show significant improvement (defined as a 50% reduction in symptoms), the same response rate that is found for SSRIs, NDRIs, and tricyclics, in this type of trial (Wagstaff, Ormrod, & Spencer, 2001). It simply does not matter what is in the medication – it might increase serotonin, decrease it, or have no effect on serotonin at all. The effect on depression is the same.
      What do you call pills, the effects of which are independent of their chemical composition? I call them “placebos.”
       
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592645/ 
      From Duke and Brown University
      Antidepressants versus placebo in major depression: an overview
      As of now, antidepressant clinical trials have an effect size of 0.30, which, although similar to the effects of treatments for many other chronic illnesses, such as hypertension, asthma and diabetes, is less than impressive.
       
      https://www.ncbi.nlm.nih.gov/pubmed/22147715 
      Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis.
      Meta-analyses and mixed-treatment comparisons of response to treatment and weighted mean differences were conducted on specific scales to rate depression. On the basis of 234 studies, no clinically relevant differences in efficacy or effectiveness were detected for the treatment of acute, continuation, and maintenance phases of MDD. 
       
       
    • By Bursting Aura
      Omega 3's are mentioned a lot for there importance for brain health. Vitamin D can also pass the blood-brain barrier, so it should be investigated for mental health also. I drove over some papers on vitamin D and depression since yesterday, so I will share some of those here. Depression impacts quality of life and it is usually implicated to be self-caused. According to science, depression can be biological, therefore depression is not always a lack of spiritual perspective or a case of "bad" vibes. My conclusion from these papers is that most cases of depression are very situational. Vitamin D deficiencies are not rare, and can potentially have a healing affect with some cases, similar to anti-depressants. The optimal ways to get vitamin D in my opinion, is sunshine and mushrooms. I would stay away from raw mushrooms due to carcinogens reported in the literature. heat destroys them though. https://www.ncbi.nlm.nih.gov/pubmed/2132000
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751336/
      Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
      "The efficacy of vitamin D supplementation in depression has raised lots of concern. Vitamin D is considered as a neurosteroid [56], and now it is attested that vitamin D metabolites can cross the blood–brain barrier [34]. Because of the widespread presence of vitamin D receptor in areas of the brain including the hippocampus which is associated with the development of depression [23], it could be speculated that there is a clinical effect of vitamin D on depression."
      https://www.ncbi.nlm.nih.gov/pubmed/26680471
      Vitamin D in anxiety and affective disorders.
      "Reduced levels of vitamin or its metabolites have been reported in various psychiatric disorders. Insufficient levels of vitamin D in depressive patients have been confirmed by many authors. Significantly lower levels of calcidiol (vitamin D) were found in men and women with depression as well as in age matched patients with anxiety disorders.
      https://www.ncbi.nlm.nih.gov/pubmed/25713056
      Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior.
      "Serotonin regulates a wide variety of brain functions and behaviors. Here, we synthesize previous findings that serotonin regulates executive function, sensory gating, and social behavior and that attention deficit hyperactivity disorder, bipolar disorder, schizophrenia, and impulsive behavior all share in common defects in these functions. It has remained unclear why supplementation with omega-3 fatty acids and vitamin D improve cognitive function and behavior in these brain disorder"
    • By Andando
      I have had HPPD for 15 years, 
      I am much better now than when it started, I have tried so many natural and psychological techniques that I feel its the right time to test if certain Medical treatment could work.
      My main symptoms are now anxiety, depression, heavy brainfog, visual snow, problems reading - writing, focusing and depersonalisation sometimes.
      I have found a neurologist in the city of Barcelona where I live, and I will like to ask you guys for a favour before I meet him:
      is there is an order for which meds are to be tried first?
      which meds in your view have been the most successful in treating some symptoms?.is there a page with these things online?
      I tried a low dose of diazepam and the day after my symptoms where very high again so I stopped, same thing with an antidepressant.
      Having said all of this I will like to share some hopeful news too:  I have been fortunate to have had days with almost no symptoms, have traveled extensively, managed to finish my BA in fine arts, lived in various countries, got my drivers license, can now read (even though i get confused sometimes), I can hold conversations much better (less DP), at the beginning of this disorder my life was very very miserable now its a lot better.
      Thank you for reading.
       
    • By justaman
      I took hppd about 2 months ago and ever since I’ve been very aware of what I’m seeing. Like at night when I’m in the car driving, I’m not sure if it’s been there before but street lights or any sort of light kinda has a glare to it, like very shiny and has like a glow to it. I’ve noticed that when I look at the moon. There’s another moon next to it but half of the size, like a glare. I suck at explaining but am I getting hppd or is all this normal? I’ve been stressing over This for a while now and I’m going to a psychologist to get checked out. 
       
      I forgot to mention that I only taken lsd once. I’ve only smoked weed before . 
    • By HDDeer
      Hey guys,
      My doctor prescribed me lamictal yesterday and as pretty much all of you know, it's one of the more highly regarded medication out there for this condition.
      My hppd is actually very bearable, the only time I struggle is when I'm alone in the house where the lsd trip happened, which leads me to a few questions.
      If I decide to take it, and my hppd gets better/worse/stays the same, if I stop taking it will I return to baseline? Has anyone else taken this med? 
Sign in to follow this  
Followers 0
cluxe

Private appt. with Doctor Plant at King's College Hospital (UK specialist)

3 posts in this topic

I finally saw Dr Plant at KCH (specialist in ophthalmology and neurology) in London yesterday. What he said to me surprised and kind of confused me, and as the appointment cost a lot (first time using private), I thought I'd share online with you guys so you don't have to cough up.

 

He started by writing down my symptoms - visual snow, floaters, after images, constant low level migraine, tinnitus, anxiety, brain fog. Then I did a peripheral field of vision test. When I got the results for that (all normal, though I felt that the swooshing colours and snow that I got in the dark room had really damaged my score before he told me the result, interestingly enough) he told me what he knew about the condition.

 

He said that he's seen hundreds of people with these symptoms, some who call it HPPD, some who consider it a migraine disorder (apparently there is a whole online community of these people - wish I could remember what he said the disorder was called), linked with the 'aura' that some people with migraines get, and some who have neither migraine problems, or have come into contact with psychedelic drugs.

 

He said the most common group of people that he sees for this condition is people who just have moved out to college or university, and are living alone for the first time in their lives, studying a lot etc. As I developed my HPPD in early 2014, half way through my dark and depressing first year of university, this definitely resonates with me. 

 

With regards to treatment, he basically said that I have to take a holistic approach - treat my whole body right, put on some weight (I'm underweight), wake up early, go to the gym, make sure that I am living a healthy and active life. This will give me the platform upon which I can recover - by relaxing into the condition, accepting it and freeing myself of the anxiety and stress that it causes me. He poo-pooed the use of "those epilepsy drugs" by which I think he meant Keppra, and also advised that I steer clear of benzodiazepines. He said that many people who have the condition make a full recovery this way, while also ceding that some don't, and that some recover and then, years later, pick it up again (which sounds absolutely awful)

 

I have strictly regimented my diet and lifestyle so that I do not consume any ethyl alcohol at all, even in cosmetics or food products (vinegar for example) in a desperate attempt to halt the progression of my HPPD - alcohol is as harmful as drugs like weed or MDMA to me in terms of exacerbating my condition. He said that this was unnecessary and that my "obsessive" behaviour was impeding my recovery, which left me confused as to his stance on drugs and alcohol - when I said that I felt I'd found some slowing in the progression of my HPPD as a result of this new lifestyle, he claimed it was a placebo effect. 

 

All in all I'm very confused about this. I think I will visit some NHS doctors and ask for Keppra to be completely honest, but maybe that's just my weakness after having been given no solid plan of action.

 

Thought? Questions?

0

Share this post


Link to post
Share on other sites

I'd definitely avoid his advice on alcohol... If you can live without it, it will have no downside, health wise... Alcohol changes the chemicals in your brain, just like any other drug. It absolutely has a huge impact on my hppd, sometimes for 4 days after drinking (and who knows what it has done to my recovery chances).

 

Unfortunately, like the rest of us, this guy seems to be using guesswork as much as anything else. Seems to be common practice... At least he didn't just wave it off as depression or psychotic behaviour, like most doctors.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
Sign in to follow this  
Followers 0