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    • By slowdancinginaburningroom
      Hi all,
      So on August 6, 2017, at around 10pm, my friend basically forced me into doing acid for the first and only time. I didn’t really want to take it, my girlfriend had just broken up with me, I had gotten blackout drunk the night before, I had just eaten, and I was also afraid of the drug because I had always been told it fries your brain. So anyways, I took one tab of tested (not synthetic [excuse my terminology I know nothing about this stuff]) in order to get high, which is the wrong reason to take the drug. I didn’t really feel anything until I started getting some minor visuals a few hours in. Then at about the 5 hour mark, the trip turned terrible. I started freaking out, I got constipated, and I began to freak out begging my friend to take me to the hospital. After about 4 more hours of this, we both agreed to take a single Xanax bar, and that helped me finally go to sleep. The next day I felt ok, things seemed a little different and I guess I knew to expect that temporarily. The day after that is when all my problems began to surface. I began to see an abnormal amount of floaters in my vision that move with my eyes, not on my own, and I also began to see afterimages of everything and I have also developed blue field entoptic phenomenon as well. These all pale in comparison to the anxiety which controls me. It’s now been 2 months (October 11, 2017) as I write this, and I haven’t been able to get good sleep on a consistent basis and I am extremely concerned that this is tearing my life apart. I can’t get the fact that I used acid out of my head. The floaters never subside unless I am in a dimly lit room, and I become extremely anxious and am not able to sleep easily at night. My social life has significantly deteriorated as well, as my friends love to smoke pot but I no longer do because I am afraid it will aggravate my HPPD. The girl who broke up with me the day of the trip gave me a second chance, but after acid I became completely obsessed with her to a point where it became necessary for her to remove me from her life, despite the fact that I was never like that with her before tripping, and I convinced myself that I could not live without her, which is downright creepy and not like the old me at all. She has called me psychotic on two different occasions since the breakup despite me not telling her anything I am suffering from. It has now been 3 weeks and my thoughts are still consumed by her and my HPPD. I haven’t smoked pot since 6 days before the trip, and since the trip I have taken one Xanax and drank on several occasions, which I have now stopped. I use an e cigarette every day and but I don’t drink caffeine. I have committed now to complete sobriety aside from the e cig, which I had quit previously for about 3 days, but did not alleviate any symptoms. I’m only 17 and I have my whole life ahead of me and right now I feel like it isn’t worth living if I have to deal with this. I made a mistake, one tab of acid, and I don’t know if I can deal with the reality that this may haunt me for the rest of my life. If this is truly permanent, I can’t see why I would want to continue to be a part of this world as it’s only been 2 months and the symptoms, however minor, are now unbearable. I cannot get professional help as my parents are non-believers in western medicine and would not send me to a psychiatrist unless I went full-blown insane. There is also no history of mental illness in my family. Any suggestion is welcome.
    • By HDDeer
      This is mainly to the newcomers like myself. For those of you just entering your days of hppd, take it from someone who also hasnt had it for very long, ive only had it for 3 months. The first month to months could very well be a hellish ride straight to satans throne. But one thing id tell you is to not lose hope, insert yourself into discussions with friends and on forums(not just about hppd but anything) take some recommended vitamins like vitamin d3 and b complex and magnesium, get a therapist you can talk to and stay active, all these things will help you get better. While my visual symptoms have not subsided, my physical symptoms on the other hand have. Ive always had social anxiety tho, so for the most part i would say i definitely feel like myself again. I attempted suicide in my first month and its now my third month and im so glad i never did. If theres three things of most importance i could tell you to do 
      1. Acceptance(accept this is your life as of right now, you cant dwell on the fact you MIGHT have this for the rest of your life because you also MIGHT NOT. My girlfriend told me i just need to take it one day at a time, we live day by day not month by month or day by month, you dont know if youll have this tomorrow or a month from now or a year, which leads to my second)
      2. Never give up hope (Accepting that you have it in my opinion is a great step to recovery. But also being hopeful in the possibility of recovery is very important) 
      Acceptance and being positive/hopeful are two great things to feel towards hppd. Its at that point imo you can feel true improvement and recovery.
      3. CEASE ALL DRUGS. I cant stress that one enough, let your brain rest.
      Those in my opinion are the three best things to do when faced with hppd. Granted i may have it milder than a lot of hppders but i do want you guys to know i havent smoked or dosed since the onset, i drank maybe 3 or 4 times(avoid that too if you can) i also have a foot injury right now but most of my improvement came when i was going to the gym and running and sweating like a dog. Hppd isnt the end, but in a lot of ways its an eye opener. 
    • By Originally
      Well, no easy way to say this. I think I have hppd. I took extremely small doses of acid in my sophmore year in high school. One 50ug and one 100ug. That's it. Prior to trying lsd I've had experiences with dxm, and weed. I only did both of these substances every now and again. 
      The visuals of today might have started a week ago, I felt no anxiety just was kinda trippy to still see stuff. Symptoms below*
      -trails 
      -slight flashing in my peripheral
      -negative and positive in prints 
      -Halos 
      -Closed eye shape-ish movement when I try to sleep
      -I sometimes right when I'm about to fall asleep I imagine noises.
      Last night I smoked some weed, after 15 min I had extreme anxiety. Felt as if I was having a panic attack, the visuals were too strong for me. I closed my eyes (still tripping) then I fell asleep. I woke up feeling neutral, just slightly anxious. All of today I've had on and off anxiousness, when I'm occupied I'm fine, down time is when I'm anxious. Been going to the gym, eating well and I plan to never do a substance again in my life. Have a party tomorrow and I want to see if my anxiety will stretch socially where it never was before. Any piece of mind from individuals here would be appreciated. Thank you for reading
    • By Thinker
      Hello everyone, my name is Matt. I'm a student and I also work alot alongside school. I have experimented with a lot of drugs in the past and have developed considerably difficult anxiety and what I think could be HPPD. This has an effect on my life, work and school. I never had any problems with my drug usage until after I saw one of my best friend leap over a balcony during a mushroom trip. My visual symptoms are tracers, after-images, halos, also got tinnitus (although that was caused by a fireworks accident) but has been excacerbated by what I think is HPPD. My eyes are very sensitive to bright lights and I see bright flashes when staring at something bright, like the sky or my computer screen. I really want some answers because this is pretty frightening for me. I'm pretty much always anxious from day to day, and I was wondering if anxiety could make HPPD symptoms worse. I have researched a lot about these disorders but there isnt alot about HPPD anywhere. So I ask you, anxiety and HPPD = worse symptoms? Thanks in advance, any help is immensely appreciated!
    • By nordlife
      Hi everyone,
      i really dont know how to start and i hope you can excuse any mistakes in language as im from europe and i even have problems using my mother language at the moment due to my mental situation
      (If you want to skip the detailed story you can scroll down to my current symptoms, which basically began after one weekend of smoking too much weed where i had something like a panic attack while smoking alone.)
      Maybe i just start with a review of my past two months where my current state began and a little about me and my drug usage.
      Im 22 years old and started with drinking alcohol with 14 like all my other friends, sure i often drunk too much in the future but only at parties and never drunk alone or had the feeling that i need alcohol, pretty normal i guess.
      Last year (2016) i started smoking weed (just smoked one time before i was 21 and felt nothing so i had no demand doing it again). Due to new friends and an interest in weed because i found out my father smokes pretty often i started to smoke with friends occasionally and somehow i liked that feeling now. I would even say that after a few times i started to love that feeling. Alcohol was no more fun and i said to myself that its better to smoke sometimes and dont drink anymore except a beer or two sometimes (even my father said that to me).
      In fall last year i moved from my families house to my own place with a friend. That change in life was awesome i was so motivated, happy and loved the new freedom. Someday i bought my first own weed (maybe because it was possible now to do anything without the parents near) and i couldnt resist trying it out alone.
      It got more often and between november 2016 and march 2017 i smoked almost everyday i got time but i was still going to work everyday and university (sober). I think it still was a „normal“ amount and sometimes i didnt smoked for 2 weeks or so without a problem.
      In March a friend of mine died i didnt knew him very good because he lived in another town but somehow it bothered me a lot (dont know if this has something to do with my problem). Smoking weed after this incident was almost the same except that i felt a little tension in my chest and when i tried to sleep it took a while. 
      Then there was the weekend whereupon everything started. On saturday march 25th two friends came over to have a nice evening and smoke some weed. I already worked the whole day and was awake since 5am but i didnt smoked for a week or two so i was excited. It was a great evening but after a while i was really tired and fell asleep for a few minutes when my friends were still there. I got some new weed and they left early like 11pm.
      I dont know why but instead of going back to bed i smoked another one alone. I felt again an odd tension in my chest and was a bit nervous but after a few hours i fell asleep. The following sunday my girlfriend had no time and i had new weed so the first thing in the morning was smoking again. I smoked three joints over the day i think and felt pretty normal (just normally stoned the whole day). Only in the evening the tension came again but harder this time and there were some „stitches“ in my chest. I was getting nervous but was able to calm down myself. Again it was harder to fall asleep this evening. It was like starting to dream while still awake and realizing it and wake up due to this feeling.
      The next morning i felt normal again i think and at midday i smoked another one with my flatmate because our internet was broken and we didnt know what to do. Suddenly i felt like being between stoned and sober and i just wanted to be fully sober. Everything felt a bit unreal like a dream somehow and the fact that our internet was not working was strange in my eyes and made me ask myself „is this really happening?“. But i managed to keep calm and said too myself that everything is normal that im just stoned and that i will be sober after a few hours.
      At the evening the internet suddenly worked again and i felt good again as far as i can remember. But instead of asking myself why i felt so strange and why i had this chest tension and stitches the last days i smoked another joint at this evening. Afterwards i was with a friend on skype playing a videogame when i suddenly had the feeling of getting a heart attack or something i had to lay down and was very anxious (i think this was my first little panic attack). The feeling came like in waves but i was able to calm down myself. It was a strange feeling i felt like not getting enough oxygen in my lungs, couldnt sit still and i just wanted to go outside. I took a walk but back home i didnt felt better. The „getting a heart attack“ feeling came multiple times again. Later it got better somehow and i was able too sleep (its hard to remember details since my memory is one of the main problems now).
      After this evening everything began and before you ask i never smoked or drank again after this evening (2 months now).
      The next day i said to my girlfriend that i feel strange somehow but not bad it was a strange feeling in my stomach like being a little sick and nervous. But the day was okay i even was in the city buying some led strips for decoration but when turning them on i realized that it make me feel very sick when the lights were flashing fast. I also got that same sick feeling in my stomach when i tried to focus small text. I thought that this weekend was just too much and its like a small withdrawal.
      The next they i went to university and in the train i was getting a bit nervous and was glad when i got off but otherwise everything seemed good i could concentrate just like normal. The only thing i noticed was that at midday a had to yawn like every 5 seconds for about an hour and felt a bit light sensitive (but it was one of the first sunny days so i thought my eyes just have to adapt to the new light condition).
      Back at home i started to feel strange and very nervous again, my heart started to beat very hard and fast and i thought again that i dont get enough oxygen. I went to the hospital because i couldnt calm down. I was so nervous that i was a bit confused, they checked my heart and blood values but everything was fine. After a while i got calm and was glad about the results. I left the hospital and felt pretty okay but was scared to stay alone. 
      The days after i started to feel dizzy and extremely anxious and thought that something really is wrong with me i cried the next days very often for no real reason i felt hopeless and empty (hard to describe that emptiness). I went to my father because i couldnt be alone. At this time i knew something is different and everything felt strange and unreal like a nightmare but i couldnt really describe it and had no idea what was going on.
      After one week since all started i couldnt focus my eyes on anything for longer than a second and felt like seeing everything with 10 fps also every flickering light made me nervous and feel sick. This got better after a few days but i realized a lot new symptoms which stayed since then. So here is a list of what i noticed after the first strong fear was gone: 
      Visual problems trails but by now only in dawn light condition every light and reflection blinds me and glares, even car, bike or traffic lights at daytime long afterimages of everything, positive and negative lots of grey and normal floaters in every light condition starbursting if the environment is dark around the light sources, gets worse if the light is far away ghosting, especially if its dark and there is white text on dark background everything seems a bit oversaturated at daytime very little static my eyes seem flickering and unsettled the whole time looking at a display is hard feels like looking through a slot or that something semi transparent is diagonal about half the display difficulty to focus my eyes on something for a time longer than a few seconds the feeling that my eyes are to slow if scrolling a website or something sometimes one of my pupils is almost double the size of the other one  
      Other problems tinnitus (had tinnitus on one ear before but now worse and on both ears) constant tension in my whole body sometimes my muscles hurt even without doing sports at the beginning it was very hard to eat constant dizziness not strong but its there everything and everyone seems foreign, especially when looking in someones eyes i feel anxious and sick (maybe dp/dr dont know) cant really sleep, it feels like i instantly start to dream when i close my eyes but never get deep sleep, i wake up every 2 hours and sometimes i cant fall asleep again i feel dumb and cant concentrate at all (brain fog?) it feels like i cant think at all if i want or have to my brain just "does nothing" im really depressed i could cry every second but only because of the thought "you ruined your life, you had everything" no feelings except the one above, i feel like a robot and act the right way only because i know how to but i dont feel it (is this dp?) everything feels like a nightmare sometimes i think im still in my bed and its still march and i hope to wake up, i know this is stupid but im somehow not sure if its not true no sense of time at all, if something happend a second ago and i think about it it feels like it happend years before, i dont have feelings connected to the memories, and they all seem to be far away (anyone know this feeling?) my own thoughts "scare me" and feel also kind of far away, even if i plan to take a shower it feels strange in my head somehow old memories are suddenly in my head even if they happened 15 years ago, they are as clear as things which happened minutes ago, also if i look at something i instantly get a memory in my head which my brain seems to associate with what im seeing (i think this is one of the reasons why i feel like im in a dream and im not in here and now) i see faces and eyes everywhere even without looking for them like my brain searches for them without my control, i see them in trees, walls etc. i can say "its just a tree" and i dont see real faces or eyes but i cant see objects just like they are without my brain starting its rollercoaster drive of thoughts and associations (pareidolia i think but its extreme) i feel like the most important filter in my brain is messed up, in the city i see every reflection, movement etc. also sounds seem louder than before and i cant ignore them (i even hear sounds i didnt heard before, they are real but i think they were filtered out before, maybe hyperacusis) sometimes i think about suicide or behaving strangely and because everything feels unreal and like a dream im scared i will do it, i feel disinhibited somehow i feel like i have forgotten how to think, all i do is associate old memories and compare all the time how things were before 2 months  
      Last week (i think) i found out about HPPD and found many of my symptoms which werent explainable with other disorders, especially those visual problems. I would love to hear some opinions about my symptoms and if they are typically for the HPPD related things like dr/dp, anxiety etc. friends say that i behave just normal only a bit sad and not as happy as before. This is what gives me a little hope because sometimes i thought i become insane.
      Tanks for reading.
       
       
       
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Painting the Void

Afobazole for anxiety (benzo substitute)

16 posts in this topic

Just thought i'd drop in to let y'all know that afobazole (Russian axiolytic/anti-depressant) has really been really helping me with my anxiety (I have had HPPD & DP/DR since age 16. I am 31 now). It's great to not be worried about benzo's or pregabalin, trying to balance sporadic use with the risk of becoming addicted. Afo takes a few weeks to start working and it's subtle compared to benzo's (no muscle relaxtion/ inhibition/ sleepyness etc. it's not much of a tranquilizer). It can be stopped at any time with no withdrawals according to the research i've looked at. When I get a bit more time I will post some more in depth analysis and links to studies, but just for now i'd though id share this info with all my HPPD brothers and sisters out there in the world. Idealy I can just keep benzo's for the odd emergency situation.

 

Just for disclosore I also take Tianeptine 12.5mg 3 times a day (it's a mood brightener and a novel kind of antidepressent that doesn't seem to make HPPD worse due to not having the same Mechanism of action as SSRI's. I mainly take tianeptine in the hope of long term neurogensis/neural plasticity and to reduce the negative effects of chronic stress on the brain. (Living with HPPD and DP is stressful right?!) It can help with anxiety to a certain extent.

 

I also take;

B12 (methylcobalamine)
Vitamin D3 (sublingual)

Ubiqionol CoQ10

Krill Oil

Astaxanthin (anti-oxident)

Chelated Magnesium / Calcium supplement

 Vitamin K2

Phosphatydylserine

+ Chinese tonic herbs - 8 Immortals / Reishi Mushroom extract / Chage mushroom extract / Ginseng

 Sublime formula.

 

jeez it's a lot of stuff, no wonder i'm broke!

 

Cheers,

Luke

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Apparently I was just discovered in July of this year that Tianeptine is a full agonist at the opioid receptor sites. I do very well with opioids but had to cut them out of my life. I wonder if this would make for a good replacement? Do you purchase online and if so where at?

 

Thank you,

Andrew

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I just order tianeptine on ebay. I used to have to import if from overseas as a generic medictaion but seems freely available as a nootropic substance now rather than being marketed as a prescription anti-depressent. Maybe Servier's patent has expired? It's actually been around in France for decades but not widely known until more recently. Afobazole I source from awakebrain.

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I am going to order me some here soon off of ebay now! I wonder since they officially discovered that it works on the opioid receptors if it will be classified as a opioid? I mean technically it is. If so I wonder if they will soon put it under the same regulations as Tramadol where you need a prescription but it isn't illegal to have(at least in my state). Like you can easily get a prescription for Tramadol online and they will mail it to you but it is pretty expensive. Might want to stack up on the Tianeptine just incase. 

 

I also suffer dp/dr and am in a constant state of derealization and the depersonalization will hit me more like a attack but I haven't had one in awhile *cross fingers*. Do you get any relief with the tianeptine? And what about the Afobazole? Really it is odd, for me opioids really help my derealization. I was hooked on oxycontin and esp hydrocodone for a few years because it gave me relief. I still had my derealization but I never paid any attention to it while on opioids. I guess the good mood I was in all the time just took my mind off of it. This is why I am wondering if Tianeptine will be the magic bullet for me. What do you think?

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I got Tianeptine off of Ebay and have been using for 2 and a half days basically now. I bought from the vendor who sells in powder form. I lost my 3ml syringe so really I have been just trying to eyeball the amount but I can say with certainty I have been taking about 30 mg dosages if not higher. I can't say I have felt much but also I have been EXTREMELY tired these past few days. I am going to finish this gram I have and then try to order it from a actually nootropic website to compare. I plan on making a solution of Tianeptine and just some distilled water and mixing it in a 30 ml container to where I have to just draw out 12.5mg and use it sublingually. I also want to try it with something like grapefruit juice because it is metabolized through the same enzymes that grapefruit juice inhibits. But as of now, I got nothing positive or negative to say about it right now. 

 

Also you mention you use it in hopes of neurogenesis. Have you ever thought about using it with melatonin? Buspar and melatonin are suppose to create neurogenesis which is why I would I mention melatonin. Or maybe even Buspar and Tianeptine? Not sure which it would be, hell why not just all 3! lol.

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Hi there,

 

good to read you've found something that helps.

Regarding your Afobazole use:

What's your dosing regimen?

How long did it take for effects to become apparent?

 

I have some from AwakeBrain that I never really gave a proper trial, so it's something I'd be up for trying again if I have a period where I'm trialling nothing.

 

Best wishes,

odisa

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Hi there,

 

good to read you've found something that helps.

Regarding your Afobazole use:

What's your dosing regimen?

How long did it take for effects to become apparent?

 

I have some from AwakeBrain that I never really gave a proper trial, so it's something I'd be up for trying again if I have a period where I'm trialling nothing.

 

Best wishes,

odisa

 

I know someone who has just started taking afobazole after I told him that someone from here recommended it and he says he feels pretty good after the 3rd day. He started off at 10mg 2x a day but tried 10mg 3x yesterday and said it made him foggy. I think that is a pretty common side effect until you get use to it. Supposedly it takes 4 weeks for peak effects so I am going to say a few days to a month until you actually feel anything. 

 

Hope this helps if Void doesn't make it back for whatever reason.

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Hey guys,

Yeah regarding the dosing of Afobazole, I just followed the recommended dosing of 1 pill taken 3 times daily. I do believe it takes 2-3 weeks before any consistent anxiolytic effect is built up, peaking at 4 weeks. My plan is to try it for 3 - 6 months, then taper off it over a few weeks. I don't believe there are any withdrawal effects like people experience with benzos. It seems to reduce anxiety but totally different mechanics of action in the brain. It is not really a sedative / tranquilizer like a benzo class of substance.

 

Other questions;

 

Tianeptine isn't really an opioid - it it technically classed as a Selective Serotonin Re-uptake Accelerator (SSRE!) ie. it does the opposite of SSRI's in a way. It increases the re-uptake rate of Serotonin, rather than blocking the re-uptake of seotonin. I have read many articles on it over the the years, but due to the Hppd/dp fuzz my working/long-term memory is never that much to rely on. Basically no one quite knows for sure  how it has it's mood brightening / anti-depressant effect. Usually down stream effects are cited, not the direct mechanism of action.

 

Andrew; most people at first get a mild euphoric buzz from tianeptine (that is powder take orally at 12.5 mg 3 x daily), but after a while this can pass. I'm really in it for the long term neurogenesis / neuroprotective effects that seem to come from continued use. (To be more accurate it seems to restore healthy neurogenesis in people with abnormal brain function ie. depression, anxiety etc..)

 

Here is an extract from a 2010 study on tianeptine 

 

Considerable progress has been made in describing the physiological and behavioral sequelae that
result from depression, but the specific factors responsible for its development and maintenance are
not well understood. Investigators have utilized animal models of stress effects on brain and behavior
to develop a better understanding of the neurobiological basis of depression, which could ultimately
produce improved treatment options for the patient. We have reviewed the findings of preclinical
research demonstrating that tianeptine prevents the deleterious effects of stress on physiology and
behavior. Tianeptine prevents chronic stress-induced morphological changes in the hippocampus and
amygdala and blocks the effects of acute stress on synaptic plasticity in the hippocampus and PFC. We
have also reviewed findings demonstrating that tianeptine has procognitive effects. Tianeptine
enhances hippocampus-dependent learning and memory and prevents the stress-induced impairment of
such processes. Tianeptine’s prevention of the adverse effects of stress on brain and behavior is likely
to contribute to its effectiveness as a treatment for people suffering from depression.
Tianeptine’s antidepressant effects appear to involve modulation of glutamatergic
neurotransmission, which resonates with evidence implicating abnormal glutamate activity in the
pathogenesis of depression. Cellular, molecular and electrophysiological studies have shown that
tianeptine prevents the stress-induced rise in amygdaloid glutamate levels and blocks stress-induced
changes in glutamate receptor currents and glutamate transporter expression in the hippocampus.
Moreover, tianeptine potentiates AMPA receptor function, as demonstrated by increasing
phosphorylation of the Ser831 and Ser845 sites on the GluR1 subunit of AMPA receptors in the
hippocampus and PFC. These latter findings may explain why tianeptine enhanced long-term (24-hours)
hippocampus-dependent memory retrieval (as reported here) and, more generally, how it facilitates
synaptic plasticity in the hippocampus. Other research has shown that tianeptine has anticonvulsant
properties, which appear to be based on its stabilization of glutamate levels in conjunction with
adenosine receptor activation.

In summary, tianeptine is a well-described antidepressant with effective actions against stressinduced
deficits of the nervous system. It is as effective as SSRIs in treating depression, produces
fewer adverse side effects and reduces anxious symptoms associated with depression without the need
for concomitant anxiolytic therapy [18–21,207]. It is therefore relevant to note that tianeptine has been
shown to ameliorate symptoms in people with post-traumatic stress disorder (PTSD) [208] and in
recent work has been shown to block the effects of intense stress on behavior and cardiovascular
systems in an animal model of PTSD [100]. Thus, the well-described antidepressant and memory
protective properties of tianeptine indicate that, in addition to its effectiveness as a treatment in mood
disorders, it potentially has broader applications, as in the treatment of anxiety.

 

Link: www.mdpi.com/1424-8247/3/10/3143/pdf

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Someone asked about the severity and nature of my anxiety. I have mild-moderate base level anxiety due to HPPD I suppose, I also experience mild/moderate agoraphobia and social anxiety. I'm not sure to what degree that is caused by the HPPD, or indirectly due to the DP/DR sensation or the way that HPPD has impacted my whole personality and life (socially, financially etc). It's understandable that a person would feel more comfortable at home if there are experiencing HPPD/DP/DR, as it is easier to control that environment and feel safer.

 

The main effect I have noticed from Afo is a big reduction in the kind of creeping anxiety (though and feelings) that would sometimes feel like it was going to spiral out into a panic attack. I used to hate that creeping paranoid anxiety, it would eat away at me and make me feel like I might lose control or go crazy. I still have some base-level of anxiety but I luckily (so far) seemed to have lost the panic.

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andrewcb;

 

regarding opipod receptor activity - I stand corrected!

 

"Tianeptine research was revolutionised in July 2014 with publication of the unexpected discovery that tianeptine is a full agonist at the μ and δ opioid receptors with negligible effect at the κ opioid receptors.[9] Selective μ opioid agonists in the brain's "hedonic hotspots" typically induce euphoria.[10] Selective kappa agonists typically induce dysphoria. The role of central delta opioid receptors is poorly understood. Dual activation of the mu and, less potently, the delta opioid receptors may be critical to tianeptine's mood-brightening and anxiolytic effect - a therapeutic action seemingly unaccompanied by the physiological tolerance and dependence that have plagued traditional opioids. Previous research into tianeptine may need to be re-evaluated in this light."

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Painting,

Yeah it is a real recent discovery, I doubt there is much activity though. Also I wanted to thank you! I am fixing to order some Afo myself, been busy trying other supplements but plan on ordering tomorrow. On another forum(a forum unrelated to HPPD or anything) we are discussing nootropics and the sort and 2 people on there have started using Afo and Tianeptine since. They used the Tianeptine first and have just more recently been using Afo but so far it seems they both like it. One guy says it gets better and better everyday. I believe he is 6 days in and 1 pill 3x a day I believe. 

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Painting; Appreciating your writings! Would love to hear more details on your afobazole experiences :) (I realize that I'm pretty much just repeating my post from Sep. 17th :P )

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Painting; Appreciating your writings! Would love to hear more details on your afobazole experiences :) (I realize that I'm pretty much just repeating my post from Sep. 17th :P )

I ordered some yesterday so it will be here next week. Will definitely keep you informed. 

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eh.. the way everybody always boasts about what they have ordered and says they will inform of the results.. and the results never come :(

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