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Hallucinogen Persisting Perception Disorder (HPPD) Support Forum

5-HT2a Antagonists: A complete cure for HPPD?

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On theory generally accepted to cause upregulation is indeed either long-term antagonism, or the lesser known process of short-term/intermittent agonism. I fear the process would be quite slow though, but indeed worth the investigation. One thing that might hinder this, is if the individual is stressed. How directly, I don't know, but I doubt it would be very beneficial. Perhaps as a reduction of visual symptoms this might help, but for other symptoms I'm not so sure.


Odisa, could you tell me more about upregulation by this lesser know process of shor-term or intermittent agonism? It got me really interested.

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Usually GCPR's are upregulated upon treatment with an antagonist. However 5-HT2A is an exception. Both 5-HT2A agonists AND antagonists downregulate 5-HT2A receptors. Having too much 5-HT2A receptors can result in depression, anxiety, OCD and schizofrenia.

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