Jump to content
Hallucinogen Persisting Perception Disorder (HPPD) Support Forum

5-HT2a Antagonists: A complete cure for HPPD?

Recommended Posts

On theory generally accepted to cause upregulation is indeed either long-term antagonism, or the lesser known process of short-term/intermittent agonism. I fear the process would be quite slow though, but indeed worth the investigation. One thing that might hinder this, is if the individual is stressed. How directly, I don't know, but I doubt it would be very beneficial. Perhaps as a reduction of visual symptoms this might help, but for other symptoms I'm not so sure.


Odisa, could you tell me more about upregulation by this lesser know process of shor-term or intermittent agonism? It got me really interested.

Share this post

Link to post
Share on other sites

Usually GCPR's are upregulated upon treatment with an antagonist. However 5-HT2A is an exception. Both 5-HT2A agonists AND antagonists downregulate 5-HT2A receptors. Having too much 5-HT2A receptors can result in depression, anxiety, OCD and schizofrenia.

Share this post

Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now


Important Information

By using this site, you agree to our Terms of Use.