onelovez Posted May 9, 2015 Report Share Posted May 9, 2015 On theory generally accepted to cause upregulation is indeed either long-term antagonism, or the lesser known process of short-term/intermittent agonism. I fear the process would be quite slow though, but indeed worth the investigation. One thing that might hinder this, is if the individual is stressed. How directly, I don't know, but I doubt it would be very beneficial. Perhaps as a reduction of visual symptoms this might help, but for other symptoms I'm not so sure. Odisa, could you tell me more about upregulation by this lesser know process of shor-term or intermittent agonism? It got me really interested. Link to comment Share on other sites More sharing options...
Diperidon Posted July 31, 2015 Report Share Posted July 31, 2015 Usually GCPR's are upregulated upon treatment with an antagonist. However 5-HT2A is an exception. Both 5-HT2A agonists AND antagonists downregulate 5-HT2A receptors. Having too much 5-HT2A receptors can result in depression, anxiety, OCD and schizofrenia. Link to comment Share on other sites More sharing options...
Onemorestep Posted August 30, 2016 Report Share Posted August 30, 2016 Can we bump this? Diperidon do you have a link to support that claim? Link to comment Share on other sites More sharing options...
Onemorestep Posted August 30, 2016 Report Share Posted August 30, 2016 "CANNABINOID RECEPTOR AGONISTS UPREGULATE AND ENHANCE SEROTONIN 2A (5-HT2A) RECEPTOR ACTIVITY VIA ERK1/2 SIGNALING" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552103/ Link to comment Share on other sites More sharing options...
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