Has aneyone tried Coluracetam

[onedayillsailagain]

Good luck with the purchase

How is 5htp related to being weary of racetams?
5htp was one of the first things I tried. Just gave me a strong placebo effect for a while because I was really desperate at the time.
It didn't make anything worse, nor did it improve anything.

As far as I can remember (which isn't that far, plus I've tried many supplements), only sometimes L-theanine will put me into a weird mood. I only take it to straighten out caffeïne jitters, but I rarely drink coffee nowadays so I've no use for it anymore.

Fluoxetine did nothing for me, neither positive or negative. I'm also quite young, so chances of ED were quite low </conjecture>.
Tianeptine helped with anxiety for the first few days, after which the effects disappeared. I hadn't tried it long enough to evaluate it properly alas.

In all, I'd say serotonergics really don't affect me in any way, and if so, to a very minor extent.

[onedayillsailagain]

Little update: I've sent a message to Ceretropic this morning, no response yet. Also, I've started writing an article in an attempt to comprehensively convey my hypothesis of Coluracetam's therapeutic potential in HPPD. I expect to finish and upload this within a day or two. That way, you won't have to digest the scattered information to understand it. Anyway, it's late so I'm off to bed. Cheers!

[must-be-a-way-to-heal]

ok thats awesome work congrats... i no longer can party like a rock star eithre lol    no more seizures on the dance floor for me lol amyhow... what u suggested is great, i will go through all the info with my new doc   ... he is a neuro psychaitrist.. I will let him digest all the info and likley go by his direction. he is quite up there when it comes to profeccionals in the the feild as he is a professor, and can access specalists all over the world immediatley which is a good assest.    all good, kind of exiting this could be great .. sill have all fingers toes and everything crossed lol and have been making some prayers also....

 

Speaking of prayer and the spiritual realm... have recentley come across something of truly rare and immense value, tho need to be free of hppd s best i can so i can reap the full benefit. most people would not understand tho it really is quite profound...  may share some later...

 

 

have an awesome week

[onedayillsailagain]

Allright, I'll try to put the pedal to the medal with the Coluracetam document I'm writing then. It would make it easier and faster for your doctor to understand. However, today I was feeling quite strange, and I've only managed to add a few paragraphs. But I'll continue working on it despite the seeming sluggishness. Though I finally got to the part where I'm about to explain how I derived the theory, so maybe that's why my brain is rioting.

Well I don't know about prayers, but I've just been telling myself: "This shit has got to work man, it's gotta! It should, it will, it's logical, it's got flashing arrows pointing towards it, it's what I've been working towards.. it's totally theoretical and unproven, but this has to be it." Maybe not the best idea, as I might be disappointed if it doesn't, but I'll probably be that anyway.

On a side note: still no word from Ceretropic, which is a little concerning. NSN updated their website, but still no sign of Coluracetam being available.

hope1: How's the custom synthesis inquiry coming along?

[Sam93]

No change on order status for me yet either, oh dear.

[must-be-a-way-to-heal]

ok much much appreciated!! will make it easier for my doc to understand..

 

I can well understand having an "off day" keep on keeping on.. and do hope your feeling much better very soon.

 

Agreed,, really have to have the right mindset to go with it, optomism is very important and a great quality.

[onedayillsailagain]

Sam93: I totally forgot it was the weekend.. I'll cut them some slack, but it would be nice to have a reply.

must-be: It's coming along a lot better than I initially expected. It's actually quite coherent, if I may say so myself. I'm quite surprised. Though one moment it makes perfect sense, the next the text is just a bunch of swimming symbols on my screen. Now is one of those moments, but I've come quite far.

All I need to do is elaborate on the different classes of procholinergics, cover the difference between muscarinic and nicotinic activation, do a summary of Coluracetam, a postscriptum, some acknowledgements and further references.

Hey, when I put it like that it doesn't seem that hard. Though I had preferred to be finished by today, but I rather be thorough than hasty.

I must add though, that by writing this article, I'm becoming increasingly convinced that Coluracetam has an unprecedented high therapeutic potential. I was afraid that by putting all the pieces together, I would find that it didn't add up at some point. On the contrary, I've only found more evidence that strengthens my theory, which is great. Now all I can do is hope to acquire Coluracetam a.s.a.p........

[onedayillsailagain]

Any word from Ceretropic yet Sam? I hate to have to do this, but tomorrow I'm gonna start a PayPal dispute I think. Well, I'll send them a warning tonight. Kind of strange to leave a customer in the dark for an entire week. I really had hoped this was gonna be it.. sigh.

Anyway, I've managed to source another supplier today.. Custom synth lab. Have only just sent them a message so obviously no response yet. PM me for details if you're interested.

The article is progressing good, and I believe I'm almost finished. I think I might finish today or tomorrow. Yeah I said that before, I know. Anyway it's a good 7 pages now. Almost done with the Coluracetam chapter, and then just a quick conclusion, acknowledgements, and further references. May sound like much, but the complicated stuff is almost behind me now.
 

[Sam93]

No word yet mate and no change on order status either, something is definitely off.

Anyway on a more positive note I'm looking forward to reading your article!

[onedayillsailagain]

Yeah I'm gonna figure out how to get my money back today..

Anyway, finally here's the article (download link): http://is.gd/Colu4HPPD

 

Any and every feedback is welcome. Cheers!

[StateOfRegret]

I've now read it. First: Splendid work!

I have a few comments, but I'm on the phone ATM, so they'll have to wait a bit.

One question, though: If the cholinergic hypothesis is correct, why do anticholinergics not greatly exacerbate symptoms of HPPD? They are certainly not beneficial, but a few users here (including myself) have taken them without serious adverse effects.

[onedayillsailagain]

Thank you!
Good question.. My guess is that that would depend on the type of anticholinergic, its potency, frequency, and dosage.
Here's an account of Scopolamine greatly exacerbating symptoms

It would appear that Ghormeh already had the same theory as mine last year, although not as extensive.
Anyway, what I forgot to mention in the article is that there are cases of anticholinergic-induced HPPD (DPH and PCP for example).
DPH is also reported to worsen HPPD. Another thing I wanted to add but forgot was that it could be possible that anticholinergic-(co)induced HPPD might be more susceptible to Coluracetam treatment than HPPD induced by other substances, though I would have to do some more research to make it less conjecture-ish.

Care to share which anticholinergic you took without worsening of symptoms?

[StateOfRegret]

Cyclizine. An antihistamine with some anticholinergic properties.

[onedayillsailagain]

Hmm I guess the anticholinergic properties of cyclizine wouldn't be that potent then, but I haven't looked it up.

On a more positive note: It would appear that Ceretropic unintentionally launched their website prematurely and didn't receive my messages until I communicated by e-mail. I received an apology and a full refund. I take back my suspicions of fraudulent activity. I was also informed that their orders are limited to North America only for the time being, so if anyone is interested in pursuing such ventures, they can consider contacting Ceretropic and decide for themselves. I can't vouch for the product though, but I'm glad I received a refund without having to go through PayPal hassles.

Sam93 I'd recommend you send them an e-mail as well to sort things out.

Furthermore I'm currently communicating with a supplier and am able to purchase >99% pure Coluracetam. However I don't know whether this is sufficiently safe for human consumption, so I'm going through all available information once more, and I might ask for advice on this over at Longecity. Pricing was pretty decent, though the minimum order amount is 10 grams. So I'll have to procure some finances, but that shouldn't be an issue.

EDIT: This patent describes the chemistry of Coluracetam in great detail (PDF - text). I'm currently reading it to see whether I can find some useful information regarding purity-safety information.

[onedayillsailagain]

So I found this in another thread (I KNEW I READ IT SOMEWHERE! damned memory) and it appears it was my own post.. haha. But anyway, I don't know if I included this in the document or not (think I didn't), but for bookkeeping's sake (and for your interest of course) I'm just gonna add it here before I forget. It's way more articulate than my ramblings, and just kind of proves my point in a few sentences. I recommend you read the full article.

 

Acetylcholine and hallucinations: disease-related compared to drug-induced alterations in human consciousness

The traditional view that derangements of the basal forebrain cholinergic system in Alzheimer's disease relate specifically to memory impairment is assessed in terms of a more general role for cortical acetylcholine in consciousness. This extends the concept that cortical acetylcholine enhances neuronal signal to noise ratio. It is suggested that muscarinic receptor activation in the cortex is involved in confining the contents of the discrete self-reported conscious "stream." In the absence of cortical acetylcholine, currently irrelevant intrinsic and sensory information, which is constantly processed in parallel at the subconscious level, enters conscious awareness. This is consistent with the ability of anti-muscarinic drugs administered medically, recreationally, or ritualistically to induce visual hallucinations and other perceptual disturbances.

[Merkan]

I do not understand this really but does this mean picking amanitas or "no-no" amanita this fall

[onedayillsailagain]

Muscarine is only a trace compound in the fly agaric Amanita muscaria; the pharmacologically more relevant compound from this mushroom is muscimol.

...

Amanita muscaria contains several biologically active agents, at least one of which, muscimol, is known to be psychoactive. Ibotenic acid, a neurotoxin, serves as a prodrug to muscimol, with approximately 10-20% converting to muscimol after ingestion.

...

Ibotenic acid is a chemical compound that is naturally occurring in the mushrooms Amanita muscaria and Amanita pantherina, among others. Ibotenic acid is a powerful neurotoxin that is used as a "brain-lesioning agent"^[1][2] and has shown to be highly neurotoxic when injected directly into the brains of mice and rats.

Definitely avoid Amanita's I'd say. And Psylocybes are 5HT agonists, so I wouldn't really count on that being beneficial either. If I was forced to choose between either, I'd definitely go for Psylocybes. Though I'd say -read this in Tommy Chong's voice- "Stay away from psychedelic mushrooms man."

Go for medicinal mushrooms instead. Check out Paul Stamets, he has some really interesting literature on medicinal mushrooms. I'd buy his book if I didn't need the money for Coluracetam.

[Merkan]

Just so you know, i wasn't serious

[onedayillsailagain]

Oh.. haha

[LarryC]

I have been to a neurologist who is familiar with HPPD.  He says it has much to do with ACh.  He suggested Aricept.  He was not my neurologist, he was giving me a cognitive test and was looking over my MRA and MRI.

[onedayillsailagain]

Hey Larry,
if you can give Aricept a try with medical supervision, that might be a good idea. Aricept is known generically under the name Donepezil, and is being discussed here.
Cheers.

[Merkan]

Thats interesting indeed, Larry. Might be on to something in this thread after all.

[LarryC]

My regular nuerologist then (2006) prescribed it.  It increased anxiety so had to stop.  Wish I could have stuck with it to see its effect.

[Syntheso]

Fantastic work onedayillsailagain! I sent it to my psych to see what he thinks. Have you sent it to Abraham?

[onedayillsailagain]

Merkan: "After all"?
LarryC: Yes unfortunately AChEIs can come with many side-effects. Perhaps it was a dose-dependent thing?
Syntheso: Thank you! Idk if a psych is familiar enough with neurosci to comprehend it. Some are pretty up-to-speed though No I haven't sent it to anyone but my own specialist, from who I have yet to receive word. I figured I'd just upload it publicly and it would reach whoever it needed reaching. I wonder what David thinks of this? I've been more focused on getting the stuff than spreading the word tbh. After all, proof is the best argument.