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Bursting Aura posted a topic in Research Articles, Publications and StudiesSome research I found on anti-depressants efficacy and comparisons with placebo. Worth a read. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/ From Harvard Antidepressants and the Placebo Effect Even the small statistical difference between antidepressants and placebos may be an enhanced placebo effect, due to the fact that most patients and doctors in clinical trials successfully break blind. The serotonin theory is as close as any theory in the history of science to having been proved wrong. Instead of curing depression, popular antidepressants may induce a biological vulnerability making people more likely to become depressed in the future. The most commonly prescribed antidepressants are SSRIs, drugs that are supposed to selectively target the neurotransmitter serotonin. But there is another antidepressant that has a very different mode of action. It is called tianeptine, and it has been approved for prescription as an antidepressant by the French drug regulatory agency. Tianeptine is an SSRE, a selective serotonin reuptake enhancer. Instead of increasing the amount of serotonin in the brain, it is supposed to decrease it. If the theory that depression is caused by a deficiency of serotonin were correct, we would expect to make depression worse. But it doesn’t. In clinical trials comparing the effects of tianeptine to those of SSRIs and tricyclic antidepressants, 63% of patients show significant improvement (defined as a 50% reduction in symptoms), the same response rate that is found for SSRIs, NDRIs, and tricyclics, in this type of trial (Wagstaff, Ormrod, & Spencer, 2001). It simply does not matter what is in the medication – it might increase serotonin, decrease it, or have no effect on serotonin at all. The effect on depression is the same. What do you call pills, the effects of which are independent of their chemical composition? I call them “placebos.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592645/ From Duke and Brown University Antidepressants versus placebo in major depression: an overview As of now, antidepressant clinical trials have an effect size of 0.30, which, although similar to the effects of treatments for many other chronic illnesses, such as hypertension, asthma and diabetes, is less than impressive. https://www.ncbi.nlm.nih.gov/pubmed/22147715 Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis. Meta-analyses and mixed-treatment comparisons of response to treatment and weighted mean differences were conducted on specific scales to rate depression. On the basis of 234 studies, no clinically relevant differences in efficacy or effectiveness were detected for the treatment of acute, continuation, and maintenance phases of MDD.
I'm seeing Dr.Abraham this Saturday and want to collect as much info as I can prior. Has anyone found that benzos do nothing for their visuals? They reduce my anxiety obviously but don't reduce my visuals, no matter the dosage it seems. If anyone has any experience with this their input would be appreciated. Especially if they found something else that worked for them. Thinking or trying sinimet.
Thought it might be interesting to share all the things we're taking currently in one place. Multi B Complex 5ml concentrated fish oil (~2g EPA, 1g DHA) Vitamin D3, 1000IU Zinc Creatine, ~5g Lions Mane, ~1g BID Tianeptine ~20mg TID Not too sure how well tianeptine's going; I've felt a little odd of late, possibly a little more lost for words. I think I'll probably give it a break and see if it changes. Probably a good idea in light of my upcoming uridine trial anyhow. Still waiting on NSI-189!