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Found 14 results

  1. This is interesting.... Was browsing some medical things today and came across this med that came out recently. It made me think it may be beneficial to this underserved area due to its unique mechanism of action. It's essentially an add on antipsychotic BUT it doesn't work like any other antipsychotic on the market. It targets 5HT2A almost exclusively as an inverse agonist and to a much lower extent at 5HT2C. You guys probably know that LSD, psychedelics, ect, target 5HT2A as an agonist, this is essentially a down regulator at that site in other words calming overexcitability. That's kind of simplifying it but it look interesting and nothing else seems to help much other than time. The side effect profile is suppose to be low because it does not effect dopamine receptors that cause Parkinsonism, Tardive dyskinesia. Its used to treat hallucinations in Parkinson's because it doesn't mess with dopamine. I know there's some people on this board that know about all the pharmacology and this looks like it's hitting where it needs to, and a new avenue, there is no other inverse agonist on the 5HTA2 receptor on the market, might be worth a shot, best of luck to all of you, give it a look. https://en.m.wikipedia.org/wiki/Pimavanserin https://en.m.wikipedia.org/wiki/Inverse_agonist https://en.m.wikipedia.org/wiki/5-HT2A_receptor http://www.parkinson.org/find-help/blogs/whats-hot/april-2016 ^^^^^ bullet points sum up above link ^^^^^ Best
  2. hppd

    I have had HPPD for about four months now. I know it's not a very long time for how long it can last but, it's so awful living with this every day. The only way I'm personally able to describe it is that the air around me is suffocating, like a have no space in an empty room filled with breathing walls, visual snow, static or tiny patterns. Another thing I have is very bad depersonalization and it's the whole reason why my anxiety comes out like it does. Before I had HPPD I have only had an anxiety attack 3-4 times but now I get one almost every other day and it's so hard to manage hanging out with people in fear that I will start freaking out of no where and have to be alone. Usually when I am inside of an attack everything is so colorful and it looks like I'm on mixtures of drugs and it can last anywhere from a couple of seconds to an hour or 2. The only thing I like so far about this whole situation is that I've been able to find myself through art. I've found that if I'm feeling anxious I can just draw something and it will really help me forget. Everyone always tells me that they like the things I do and how they love that I found a unique style that belongs to me. I'm very happy that those people are supporting me even though I still wish I hadn't done the things I did to get this way. It all started when I did 3 psychedelics in over the corse of 8 days including: LSD, LSA and DXM. It took a while for my symptoms to come through but I can tell that all 3 of these drugs made a huge difference in my life because I feel the things I felt to this day when I was in all of those trips. I have been on a few medications so far to help the visuals and depersonalization. Including Prozac, Busbar, Abilify and Gabapentin. All of these drugs made things worse for me and I wish I never took any of them. Except for Gabapentin because I have a feeling it might work in a higher dosage. I have talked to my psychiatrist about HPPD and she had no clue what it was and didn't seem interested. She just jumped the gun on antipsychotics and labeled me as "psychotic" (because she's an asshole) I've done enough research to know that only in very small cases do antipsychotics help HPPD because it isn't the same thing as Psychosis at all. In my research ive found that Primarily benzos including Klonopin, Valium and Xanax work the best for depersonalization and visuals. And levetiracetam has been able to just help visuals. I really want to find a psychiatrist who understands instead of one who asks me if Acid and LSA are both LSD. I need someone who actually knows about drugs but my mother won't let me switch. Is there anyway that I can get her to understand or believe me and get me the medications I need without seeming like I'm pharma-shopping?
  3. For the first couple years I jumped around to different doctors. No one had answers. After all this time I finally got the courage to google it. I can't beleive a lot of answers were so close this whole time. Ive been on Effexor now for more years then I can remember. It barely keeps me afloat. Ive been reading these pages all day and keep hearing about Kepra. I made a doctors appointment. Any advice about dosage or combinations would be greatly appreciated.
  4. My psych agreed to start me on clonidine, saying that there's at least anecdotal reports of it easing HPPD symptoms. Has anyone had success with it?
  5. For those of you who have tried SSRI's have they increased your visual symptoms or decreased them? Or had no apparent effect? I'm considering changing my medication since it seems like a lot of people are saying SSRI's make HPPD worse. Also if it is making my symptoms worse should they return to a baseline when I go off them? I went on the ssri around the same time my HPPd symtoms began so it's my hope that they might die down a bit if I discontinue the drugs. Currently on 20mg lexapro
  6. Hi everyone, Thanks for your time to anyone who is reading this. I have aways been a "sensory sensitive" person (i.e. only kid on a youth soccer team to have to wear sunglass sports goggles). I took LSD (one time only) during the summer after I graduated from college in 2006. Upon waking up the next morning (after little sleep lol) and getting my day started, it was overwhelmingly evident that something in my brain had changed. I have for the 8 years since then been dealing with a variety of extremely bothersome, what I would describe as, visual sensory overload issues. My brain is now agitated and overwhelmed by all sorts of visual stimuli, most notably unnatural lighting that I encounter in the evening (i.e. all forms of indoor lighting, car headlights, porchlights etc). Also, as crazy as it may sound, my brain is often extremely agitated and distracted by shadows that are created by such lights...things that my brain would have formerly subconsciously filtered out. For instance, an overhead fan with a light behind it will drive me absolutely crazy. I also have issues during daytime hours, though not as intensely, as I am also now more sensitive to brightness from the sun (as well as daytime shadows). When I am in the throes of my "symptoms", my experience ranges from mild agitation to literally feeling like my brain is on fire and in desperate need of someone popping my skull open to dump ice water onto it. This latter feeling generally arises from prolonged exposure, for instance a situation where I cannot just go take a shower to calm my brain down or lie down in a dark room for a while. I don't know if the condition I have is precisely HPPD, as I do not experience visual snow, halos, trailers, or any of the other "common symptoms" I have seen listed under diagnosis criteria for HPPD. However, I keep coming back to this forum and other websites related to HPPD because I have had a persisting sensory condition that was (however predisposed I may have been) either caused or multiplied a hundred times by taking a psychedelic drug. To wrap up with a few other details: I have suffered from Depersonalization Disorder since my senior year of high school (that I am certain was triggered or at least exacerbated by marijuana use). I have not taken any psychedelic drugs since my LSD experience, and have not smoked pot in about 7 years as it makes all of my symptoms much worse. I mostly try to sleep and exercise consistently to help me battle my problems. I have been to several people for help. A neurologist told me frankly that he understood in theory what I was saying, but had no idea what to do. I was later prescribed Xanax by a psychiatrist. It has helped me quite a bit and I generally take it at night time when my symptoms hit at their worst. I do hope to get off of it someday soon because of the zombie-ish feeling it can create. But for now, I much prefer it to the suffering I endure without it. I have been disciplined and have not upped my Xanax dosage during the 2 1/2 years I have been taking it. I believe that the condition I deal with might line up more closely with some of the sensory overload issues faced by MS or Autistic patients. It might very well be that certain receptors were overstimulated during my LSD experience and now my GABA production has been permanently affected. This would explain why taking a Benzo, like Xanax, temporarily makes me feel better. Drinking alcohol, though I don't often engage in it, has a slightly similar calming effect. If anyone has any thoughts, I would greatly appreciate hearing them. I am quite desperate, to be frank, and am open to all suggestions. N-Met is a product I have seen marketed for sensory overload sufferers, as well as GABA Calm. Keppra intrigues me as well because of it's work on GABA receptors, though I am a bit nervous about trying an anti-convulsant. I have also considered meeting with an Occupational Therapist, or a hypnotist. Thanks everyone! DJ
  7. Hey all! I'm still searching for a medication to treat my anxiety problems that won't simultaneously aggravate my HPPD. As many of you know, that is one tough nut to crack. My immediate thoughts: SSRIs: Seem somewhat effective for my anxiety. Aggravates visuals, had to discontinue. At least HPPD symptoms returned to ''baseline'' upon discontinuation. Benzodiazepines: Greatly attenuates my anxiety (particularly etizolam and clonazepam) and helps HPPD symptoms as well (particularly clonazepam). Very addictive, not a long term solution. I build tolerance to benzodiazepines pretty quickly. Buspirone: Seems too ineffective to be worth it (never actually tried this one) Pregabalin/gabapentin: Seem to have many of the same pitfalls as benzos, plus some extra common side effects(?) Beta blockers: Ineffective in managing my anxiety, since it doesn't primarily manifest with tachycardia, tremors, flushing etc. Atypical antipsychotics: Seems like a dangerous combo w/HPPD (particularly risperidone). Older/atypical antidepressants, such as TCAs: Never tried any of those. Very interested in hearing personal experiences or ideas about any non-SSRI antidepressants useful in treating anxiety, particularly about how they interact with HPPD. Thanks in advance, folks Hope you're feeling all right. Looking forward to hear any and all thought on possible anxiety medications w/HPPD.
  8. hey guys, im new here, so i have been suffering from this thing for about 2 months now, but i actually don't know what it is ? whether DP/DR ? or HPPD ? or something else. i got all this from smoking weed, out of a printing paper (A4). havent touched LSD, MDMA etc ever. ohh!, and i never had that 'i am going to die feeling, when i was high'. and i believe i have a bit of social anxiety. i'm a 22 year old male, with no history of mental illnesses. here is what i have:- visual snow (mostly in darkness and dim lights) very sensitive to all kinds of light. (even sunlight) very intense migrainous headaches at the base of skull slight halos around streetlights, and starbursts from distant lights. only negative afterimages faint ringing in ears, ear pain and popping in the right ear from time to time some sounds feel amplified floaters in white backgrounds changed visual perception the vision where u feel ur still high, or stoned. (is this derealization ?) anxiety (along with the 1001 symptoms that come with it) a strange thing which occurs to me is that, i see streaking/starbursting on lights which are far away, but if the same light source comes close, the streaking goes away! here is what i don't have:- trails/tracers blue field entoptic phenomena colour confusion movement in objects and walls geometric patterns size distortions i saw, both eye doctors and neurologists, got an MRI scan, and everything seems to be normal, according to the doctors! i've yet to see a mental doctor. i got prescribed klonopin, took it a few times, for me it doesn't do much, other than making me sleepy. sorry for making such a long post. any help is greatly appreciated. thanks
  9. need help asap please! i nearly committed suicide the other day and would really appreciate if anyone could help me in finding a doctor that understands hppd in my area. I live in Tacoma, WA, USA, which is about 30 miles south of Seattle, WA. I just want to be better so i can finally have the confidence to meet a girl and to love as well as my lifelong dream to pursue a career as a piano composer. I am 18 years old now and have had it since i was 16 (September 2, 2012)- yes i remember the exact date because since then it has been a living nightmare. Ever since I developed HPPD I have had Constant Depression and Consistent Anxiety of the extreme along with the disturbing visual snow and hallucinations.
  10. I'm sure there has to be a thread for this somewhere but I couldn't seem to find any info so if a thread already exists please let me know. I understand recreational drugs can make HPPD worse, permanently in some circumstances. And as we all know alcohol and caffeine can affect it as well. My question is, are there any prescription meds known to worsen HPPD, particularly, meds that don't have a strong psychoactive component and aren't typically associated with neurological side effects? The reason I ask is because I take a TNF-inhibitor for severe arthritis, which can make me drowsy for a couple hours but that's the only real side-effect I've experienced. Neurological side effects are rare and mostly include temporary numbness/tingling. I've had HPPD for a little over a year and, despite having cut out all rec drugs including alcohol and caffeine, some of my HPPD visuals (snow/trails/after images) have slowly progressed over the past year and I'm wondering if it is due to this medication, which I have been taking for years. I've never noticed a major spike in symptoms immediately after taking it, just a slow progression. Anybody have any stories relating to this? I know HPPD can take a long time to fully develop but does it typically take over a year? Discontinuing this medication is not a good option for me. http://en.wikipedia.org/wiki/TNF_inhibitor
  11. I have a huge problem, my neurologist won't subscribe me keppra. I explained her about HPPD but I'm not good of a talker.. I used to be very social but now i suffer from HPPD I'm not that smooth anymore. She said she could only help me with issues in the form of neurology, like migraine. She also said I probably have to go to a psychiatrist with my hppd What do I have to do to get keppra from a neurologist / doctor / psychiatrist? Please, I need advice!