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Found 9 results

  1. After a lot of research, i came across this medical review : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736944/Very interesting and rare hppd study. Overall, it seems that Lamotrigine has been able to cure long term HPPD like mine is , and for good, or significantly decrease visual disturbances and symptoms. I'm actually testing nootropics on many levels, but i'm willing to step-up to more epileptic oriented drugs. Anyone has more input about Lamotrigine on long lasted HPPD (mine is about 20 years old...) ?
  2. Hey guys, My doctor prescribed me lamictal yesterday and as pretty much all of you know, it's one of the more highly regarded medication out there for this condition. My hppd is actually very bearable, the only time I struggle is when I'm alone in the house where the lsd trip happened, which leads me to a few questions. If I decide to take it, and my hppd gets better/worse/stays the same, if I stop taking it will I return to baseline? Has anyone else taken this med?
  3. So given that agomelatine doesn't seem to have done much of anything it's very likely I'll be prescribed Lamictal next Tuesday. When I mentioned levetiracetam the psychiatrist I'm seeing either didn't have much to say about it or didn't want to go there for some reason, but he praised Lamictal and said it'd be the next move in my treatment. Thing is, I know Keppra tends to be the most well-regarded anticonvulsant by members here and seems to have the most success stories, but I'm not sure if that's just because more people have tried it. I'm not well-versed in the pharmacological actions of either and how they differ but a lot of studies/reports seem to regard them as relatively comparable as far as treatment of epilepsy goes. I know there's the study, but is there any reason Keppra was chosen for the study over Lamictal, and were the same study to be done with Lamictal is there much reason to believe the results would be less positive? I really just want to know if there's any concrete reason that I might want to really push for Keppra over Lamictal; I don't especially want to get into an argument about this stuff with a professor of psychiatry unless I'm confident there's a solid basis for doing so Oh, and while I'm at it I'd like to ask: if one's HPPD fails to respond to treatment with one anticonvulsant, is that reason to believe it won't respond to another and that avenue of treatment should be abandoned?
  4. So, it's been a couple months and I'm at my target dose of 200mg lamotrigine daily. Still on 2mg clonazepam daily, but will be starting a taper off of it within the next month or so. No signs of addiction or dependence so I'm not too worried about tapering off it. I'm pretty much the same as I was when I posted the first report. However, the double images/ghosting has improved quite a bit and now seems to come in waves rather than being constant. There are days where it's the same as it was before treatment, and the there are days where it's almost not noticeable unless I purposefully look for it. Another thing of note, it seems to now only occur with brightly colored/reflective objects that are being hit with intense light OR with lights that emit at a high intensity. Also, it sort of follows a cosine like trend where it's at its worse in the morning and night, but not so bad midday (this is perhaps a function simply of eye adjustment, i.e., the eyes adjust to light after being in darkness for an extended period and the eyes adjusting to darkness after being exposed to light for an extended period of time). Ghosting/double vision with text on a computer screen is almost nonexistent now, it comes and goes but for the most part, it isn't present. However, all other archetypal symptoms are still present at their normal intensities. I plan on going the full recommended 12 months to see how this turns out. The improvements make me hopeful. Another thing of note, I will be starting a course of haloperidol soon due to an increase in psychotic symptoms (pdoc is starting to get worried and wants to get this under control ASAP before I end up in the looney bin). My target dose will be 5mg once daily, starting at 2mg once daily. He recommended it since it primarily affects only the dopamine receptors, specifically the D2 receptors and HPPD seems to be primarily linked with the serotonin receptors, as we all know by now the 5-HT2A receptors in particular, which most modern APs have an affinity for along with the dopamine receptors. In his words, he said it would either have a positive effect for HPPD or be completely benign. In Lerner's clinical literature review, dopamine antagonists (i.e. typical antipsychotics) seem to be either helpful or benign with regards to HPPD. So, I'm hoping it helps or is benign and doesn't worsen HPPD. The only thing that surprises me is that no one has really tried it yet with HPPD, except for a few people here on the forums. I think this is because most HPPD'ers are told not to even approach APs regardless of their generation (typical/atypical), but this seems to stem mostly from experiences with only one AP, risperidone and not others. We'll see how this plays out. If there is anyone else that has tried haloperidol with HPPD, it would be much appreciated if you could give an anecdotal report of your experience, was it a success, complete failure, so-so results, etc. If it works, great. If it doesn't, well, I'll just keep on keeping on and move on to something else (likely clonidine, levetiracetam, perphenazine and a few others, definitely not levodopa though since I have an underlying psychotic condition).
  5. I've been on the cloneazepam for about 1.75 months and the lamotrigine for about 3 weeks, increasing dosage by 25mg each week until a target dose of 175mg-200mg is achieved (started at 25mg so I'm at 75mg daily right now), after which treatment is to continue for at least 12 months. Here is a short report of what has been going on so far in terms of symptoms: Improvements: Anxiety/panic is almost non-existent (as expected with the clonazepam). I'm also much more social, and to be honest, I seem to be more bold, especially with regards to the opposite sex, you know flirting and whatnot (even went on a pseudo-date with a coworker whom I'm sort of pursuing as a romantic interest ) even though I'm not the most attractive fish in the sea. Social interactions no longer scare the living shit out of me. Eye strain used to severely increase symptoms, to the point of almost being blind after sitting at my computer for a few hours. Eye strain now, while it still increases symptoms, does not worsen symptoms as severely as it did. Ghosting/double-images are reduced in intensity and seem to be only concentrated around brightly lit or colored things now (gets worse when it's really sunny out). Also it seems I have to focus on something in order to get ghosting. Can also read text on a computer screen much more easily now. Depression. Significant improvements here, while I'm still fairly depressed, I'm nowhere near where I was about 2 months ago (constantly suicidal, self harming, engaging in purposefully risky behavior, etc.) Brain fog/confusion/cognitive impairment/concentration problems. Again, much improvement here. I can think much more clearly now and no longer get frustrated when presented with a hard problem. I'm also currently participating in a research internship and am able to understand the rather abstract and hard to grasp concepts fairly easily (coworkers not so much ) Somewhat related to the depression, but I have a much more positive outlook on things now and am more optimistic and accepting about my mental/neurological disorders, of which there are 4. Symptoms lacking improvement: Image trailing. Trailing is still constant and at the same level as it was when this all started. Oscillopsia/breathing objects. I still get visual jittering (things look like they're buzzing or otherwise moving) and when there are areas of high contrast gradients/edges (light to dark/dark to light), I still get severe breathing phenomena. Palinopsia/after-images. Still get both negative and positive after-images that last about the same time as before (a few seconds to a few minutes depending on image intensity). Light beaming/beams/star-bursting. Still get long beams of light that emanate from light sources and still get starbursting around highly concentrated points of light (headlights, streetlamps, LEDs, etc.) Visual snow. Same as before. Scotomas/auras. I still get the odd scotoma/aura every one in awhile, usually at random times and usually in the form of shapeless, colorless blobs. Ghosting/double images. While there has been some improvement, it is still not to the level I would like it to be Depersonalization/derealization. While the grounding/coping techniques my psychologist taught me (and ones I came up with by myself like breath holding and cognitive interaction with my environment) help to ease and stop an attack, I still get episodes of DP/DR. ​Negative side effects: Fatigue, though this is expected with the combo of lamotrigine and clonazepam. Drowsiness and oversleeping. I have, on more than one occasion since starting this course of treatment, overslept by a large margin and either ended missing class or being late to work. Some sexual dysfunction. It's kind of difficult for me to keep and get a you know what for you know what purpose (a man has needs ). Also difficult to *ahem* sow my seed in a timely manner. Decrease in motivation to do things. While I've always been kind of a lazy person, the fatigue and drowsiness from the meds just make me want to sit down and chillout for a few hours listening to some quality tunes. Sort of a stoned, couch lock feeling. Increased appetite, though this isn't that much of a bad thing. Also, question for those who have taken this combo, is having a beer or two here and there while on these meds harmful? I do know these meds when used with alcohol increase drowsiness and decrease tolerance to alcohol, but so far I've found that small amounts of alcohol, like a light beer, don't do much. The only sort of scary experience I had was when I stupidly drank a few shots worth of high quality bourbon in a homemade cocktail. Woke up naked on top of a pile of clothes in my laundry room and not having a clue where the hell I was or how I got there. I plan to continue treatment with the lamotrigine for the recommended time of 12 months. I know it seems long, but I think it will be the key to being rid of this disease. I would also suggest lamotrigine for the people of this board. It will take awhile for it to have any sort of significant improvements on symptoms, about 6-12 months at least. The improvements I described are minor, but nonetheless hopeful for me as they tell me the medication is working and having a positive effect. I do plan on tapering off the clonazepam though as I would rather not have to deal with benzo WD on top of all this. Anyways, that's my report so far and I'll probably post another report at the end of the summer since I should be at the full 175-200mg dose of lamotrigine by then. If you have any questions, feel free to ask!
  6. Hi there! For the past two years, I have been having difficulties with video projectors, and sometimes leds. When I watched anything on a projector, the image seperated into red-green-blue trails. Usually a great sense of terror and panic attacks accompanied the visual disturbance. It was awful for me, because as an art student I am exposed to projectors constantly, and I had to give up on many of my classes because of it. It all started about a month after a very bad psilocybin experience. (I guess I haven't been exposed to any projectors in between) At the time I also experienced constant sleep paralysis, disturbing lucid dreams which started over and over when I tried to wake up... When I mentioned this to my psychiatrist, he didn't seem to care and prescribed me antidepressants and antipsychotics for my depression and general anxiety (first prozac and rexapin, then cymbalta and seroquel). I started seeing another pdoc, and it was the same with him. I told my parents about my problem (not the psilocybin experience though) and a neurologist who is a family friend suggested that I get screened for epilepsy. I went to an epilepsy expert. She wanted EEGs and MRIs which came out clear. I told about my drug use, and gave her a list of drugs I have tried over the years. She said that it must be a result of my drug use, but offered nothing to help. About 6 months ago I started seeing another pdoc. She said that some minor epileptic cases may not be diagnosed by EEGs, and prescribed me a low dose Lamictal. The main reason for Lamictal was that it acted as a mood stabilizer, but she also wanted to see if it helped with these symptoms. I started with 25 mg, around 75 mgs the visual disturbances vanished (now I'm using 200mgs but that's for the mood stabilizing effects). Well, altough I mentioned my drug use none of these doctors mentioned anything about HPPD, I guess they just don't know about it. I just found out about it myself, and after reading some articles and the posts on this forum, it seems a lot more relevant to me than photosensitive epilepsy. Still, it was treated by the instincts of my pdoc I guess I'll talk more about this with her next time we meet. What I'm curious about is, is this thing curable? Or will it return if I stop using Lamictal?
  7. Yeah, saw the psych today and got the all-hallowed script. I'm tentatively hopeful. Just a few things I'd like some insight on, if anyone can help. As far as doing a fair trial, what should I omit from my current supplement regime? It seems harmless to stick with my fish oil, multivitamin, B-complex, vitamin D3, and creatine. I've been taking ~4g of magnesium BID (morning and night), and given that the intention of that isn't purely dietary it seems logical to cut it out whilst figuring out if Lamictal suits. I'm fresh out of NAC which is probably timely as having something else affecting glutamate could potentially skew the results. If it looks like Lamictal's gonna be a long-term thing I'll probably add it back though as the "glutamate management" of NAC sounds as though it's likely to be somewhat synergistic with Lamictal's glutamate inhibition, from what I've read - there are certainly a lot of people on Lamictal who also supplement NAC on their psych's advice. I received some damiana, passiflora and skullcap by mail today and couldn't help myself - I'm vaping a mixture of damiana and passiflora right now, haha. I wasn't expecting anything this noticeable! A definite, slight warmth in my head and an overall "chilled out" feeling, with little-to-none of the distractability/poor articulation/trippiness of weed. Pretty pleasant. Is it advisable that I otherwise abstain from them while trialling Lamictal? Tapering up to even the minimum effective dose is going to take a month and it'd be nice to be able to chill out between now and then a bit, but if those wiser than me think it's not a risk worth taking I'll endure! He was really cool and semi-fudged the script so that I'm not technically taking it off-label and so can get the government-subsidised discount on it. Additionally he prescribed me 50mg despite recommending I start off at 25mg for further bang-for-my-buck, haha. Thing is, the bloody pharmacist didn't ask me if I wanted regular pills or chewable ones, and it was only after I cracked the packet open that I realised I'd wound up with the latter, which are impossible to split in half without them crumbling everywhere. I'm tempted to be cheeky and just start at 50, and if the dreaded rash begins to show I'll move back to 25. There are a bunch of reports online of people starting at 50 with no or little issue and my general impatience is making the idea very tempting. Recommendations? Finally, just a couple things I want to know in the event that I do wind up taking this for an extended period. If its effects are mild at best and I want to give keppra a shot, would it be better to taper fully off lamictal then try keppra on its own or would it be okay to start keppra whilst on lamictal? I know it's a cross-that-bridge-when-you-come-to-it situation but I can't help but speculate! Also, in response to the buzz surrounding procholinergics that coluracetam and Odisa's enthusiasm has generated, I tried choline/ALCAR/inositol a couple of times last week and the effect was definitely positive, if subtle. Is there any reason I wouldn't be able to add these on top of Lamictal down the track that anyone's aware of? How about coluracetam? I'll look into this stuff myself tomorrow but figured it was worth dipping into the collective consciousness, haha. Thanks for any responses and I hope all is well!
  8. I found this article published in June of 2013. It's definitely worth reading. I tried uploading the pdf file in research articles, but the file is too big.
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