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Hey guys, so lately with NSI-189 and all I've been looking in to neurogenic substances. Maybe some of you have heard of this small molecule. 7,8 dihydroxyflavone (7,8-DHF), is a potent agonist at the TrkB receptor. More about the TrkB receptor here. Here's one study in particular I find interesting: A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect and: 7,8-Dihydroxyflavone and its Derivatives Useful for Treatment of Neurodegenerative Diseases and Drug Reduces the Increase in Fear Caused by Previous Traumatic Experiences in Mice Effect of 7,8 - Dihydroxyflavone, a Small - Molecule TrkB Agonist, on Emotional Learning (a neat PDF, which also mentions that 7,8-DHF protects against kainic acid induced neuronal apoptosis). Questionably legitimate experience: source Longecity topics: http://www.longecity.org/forum/topic/55126-cure-depression-in-3-4-days-study/ http://www.longecity.org/forum/topic/67667-78-dihydroxyflavone/ Group buy: http://www.longecity.org/forum/topic/67693-official-78-dihydroxyflavone-group-buy/ "yadayada" is working on acquiring some too. I went ahead and ordered 1 gram of the stuff from the last link. Some things to consider: No in vivo human studies have been conducted TrkB agonism may cause eventual downregulation There are some concerns of BDNF overexpression being detrimental to one's neurological health Human equivalent dose has been calculated to be around 30mg, so a gram should be enough for a month. May be synergistic with NSI-189 and Cerebrolysin. If you've any questions; shoot. Cheers.
So. I'm very spaced out currently. I'll add more about Cerebrolysin as soon as my brain permits, but basically it's porcine derived peptides which spark brain growth. Or something like that.. didn't get into details. I can't wait for NSI-189 lying around like this any longer, and this seems to have a high chance of helping me, moreover it seems rather similar save the RoA. Anyway, many tout it as the most potent nootropic they've ever used. I've even read 2 accounts of it improving depersonalization, one of them quite drastically. I suggest you read through the (long) thread at Longecity however, if you're interested. This one has been on the back of my mind for so long; I almost forgot it existed. When I first started looking into Nootropics, it was the first thing that caught my eye based on the (sometimes very impressive) user reports. However, the only downside is the RoA. Intramuscular injection. This is why I never bothered with it, as IM injections seemed rather extreme to me. Though now more than ever I really, really, need something that works. The upside however is that it should work relatively quickly (1-20 days, with an average of 4-5 days) and should be highly efficacious if it works. So, I went ahead and ordered myself 200ml (20 x 10ml) Cerebrolysin from Nootropic.eu. (warning: very expensive). I'll be spending the coming days trying to figure out how to do intramuscular injections, ordering needles, etc. (I've never done an injection.. hell I've even missed a lot of shots!). The only fear I have is that I'll fuck up due to my current cognitive state (I barely made a sandwhich today.. hoping Aniracetam will help with that short-term), but other than that I'm pretty sure it should be harmless. And I guess.. would suck to waste almost 300 euros on a failed experiment and jabbing my thigh for nothing. I haven't found a single mention of Cerebrolysin on HPPDonline.. Does anyone have any experience with this (I doubt it)? I'm still reading in to it, but doses tend to be 5-10ml per day, either every other day, or 5 on 2 off. I figured 10ml 5 on 2 off for 4 weeks should be sufficient to gauge efficacy. Of course this is subject to adjustments. Thoughts anyone?