Fawkinchit

St. Johns Wort is clearly something to be avoided in HPPD, as SSRIs are known to exasperate symptoms. Rabdosia has almost no information available as far as modern studies are concerned. Is there any information that you have found that leads you to believe it may be beneficial?

Wants a cure, doesnt have 30 minutes... lol Edit: God damn 7 year bump what the hell.

Not everyone has had the best experiences with it, and probably because it simply just doesn't cure the condition. I see a lot of HPPD sufferers that cant tolerate any of these neurotransmitter modulating drugs. Granted though some have seen some benefit. Which will primarily be due to its ability to lessen neurotransmitters, so it likely helps to quiet some of the cortical disinhibition seen in HPPD, however its mechanism of action is unknown, and it(like most other pharmaceuticals) does not appear to treat the underlying cause of this condition.

Modern medicine has termed most electrical devices in the field of medicine as "Quackery", whenever medical science does this the sheep move as though they were a religious cult. So now days everything thinks these devices are more for gimmicks. However funny people think they may be, there are a few that actually tend to show outstanding results worthy of further investigation. Mass population though, their minds are too lazy for real reading and thoughtful acknowledgement.

I would like to bump this thread, has anyone else gotten hppd from mescaline? This is a very interesting topic, if more people could answer please.

Hey good morning and thanks for posting! Yes, what you're saying essentially is that HPPD could be caused by neuronal loss, this is accurate, and glial scar formation does always follow neuronal loss. It should be noted that neuronal damage with out loss of the neuron however does not typically result in glial scar formation. In one of my older threads I do cover some of the interesting facts around glial scar formation. One of those points to be noted is that even though it is believed to be a "road block" for regeneration, there is actually no evidence of that, and it could actually be the initial steps in building a framework for regeneration(This may be doubted by what's been said on chondroitinase, but I will cover that also). Glial scar should be understood as well as to not be confused with normal scarring, there are no fibroblasts within the central nervous system, and so no fibrous elements are produced, which is a great thing. Glial scar tissue is made up simply of astrocytes, and I believe oligodendrocytes, which are cells mainly there for supporting neurons. As for chondroitinase it sounds great in the way they title everything, like "functional recovery", and it can be considered improvement technically, because the animals do show improvement. However looking at the details of the studies it should be noted what they say is the cause of the improvement. I'll quote the studies. "These include promoting regeneration of injured axons, plasticity of uninjured pathways and neuroprotection of injured projection neurons." "promoted regeneration of both ascending sensory projections and descending corticospinal tract axons." So it should be correctly understood that they are removing components of the glial scarring, and it does promote healing, however, and most unfortunately, its not neurogenesis, which is primary component you will want in the case of neuronal loss. It does allow for new connections, axons, etc. It should be noted as well that these studies are in spinal cord injuries which are far less complex than brain injury. So that should be the main take away here. If HPPD is neuronal loss, then neurogenesis is a key component for treatment, also if that is the case, there will be glial scarring. However glial scarring may not be the block for neurogenesis, and in my opinion its proven that it is not by these studies, as removing the network shows no sign of neurogenesis. This would lead me closer to believe that its a framework for neurogenesis. The brain stimulation therapy study is interesting though and they do bring to light some interesting questions, and shows that there may be more underlying factors to these conditions than just neuronal loss. I do believe that if HPPD is associated with neuronal loss that large scale recovery can still be possible with amending these underlying issues aside neuronal loss. A lot of those issues are what I mention in this thread, mitochondrial dysfunction being the main one, axonal damage secondly, and third there could be microvascular dysfunction as well, which I am working on right now, and already have something people can try, I will make a post on it in a couple weeks probably.

Nice, you're obviously pretty intelligent. I apologize I may have misunderstood a couple things you've said regarding current drug use. We are definitely not profitable lmao. As far as antibiotics and dreams I do not currently have any information on, its the first I have heard it for HPPD sufferers. I haven't done very extensive research on antibiotics either to know how they may potentially interact with the nervous system as well. I do know there are quite a lot of compounds(especially herbs) that stimulate dreams though, so its not too unheard of imo, as to the direct correlation I am unsure of. It is really interesting that the majority of serotonin is actually produced by the gut, no doubt, and there are a LOT of neurons there, however, a simple study of anatomical injury and loss simply and easily demonstrates that brain trauma vs intestinal trauma supersedes neuro cognitive deficits easily, and there are predominately zero to no cognitive deficits lost in intestinal damage. Unless you have found studies I am unaware of. Welcome by the way. Glad to have you here.

No, and stop doing drugs. They do in fact cause significant neuronal damage, and most likely neuronal loss, in my thread the cause of HPPD and possible treatments, I talk about this, and why only some people get HPPD, its all relatively simple. Please stop shitting on your brain and please spread the word. Thank you!

This, also the study that I posted in my thread, The cause of HPPD, explains that axonal damage initiated by 5ht2a receptor overstimulation lasts up to two years. There may be quite a lot of way to speed this up, but its technically all experimental at that point. In my thread I recommend Niacin.

This study interestingly enough shows that drugs will have far greater effects on brains that are of a more susceptible nature. Schizophrenic patients have psychotic reactions to Ketamine. It should be noted as well that Ketamine is known to cause HPPD, and also acts on 5ht2a receptors. https://stm.sciencemag.org/content/8/353/353ec134 Also interesting at the end of this article it almost seems as though they are implying that ketamine is used to induce schizophrenia in rat models. https://pubmed.ncbi.nlm.nih.gov/27847437/

As I have previously mentioned, this study is referencing nicotinamide, which is a form of Niacin, but not Niacin, Niacin is nicotinic acid, and does not have the same side affects as nicotinamide. The study if you read that you posted also says that safe doses for nicotinamide are 1500mg, and express a great deal of neuroprotective effects. The dose I recommend for Niacin is 1gram only. By shit fuck, yes, I mean everything is fucked, and in my honest opinion, personally and without evidence of it I'm assuming HPPD sufferers are sadly in fact facing higher end levels of neuronal loss. Eventually I will get around as to why neurogenesis most likely wont be functional, I went over this years ago when I just assumed that HPPD was neuronal loss, but I never had evidence for it. Anyways I still don't know for sure how much neuronal loss is anticipated for this condition, but the underlying mechanisms and causative factors are clearly defined and easily observed at this point. I do also need to study a little more profusely axonal damage and repair mechanisms and prognosis. Edit: It appears as well that the studies that showed abnormal liver enzymes were with preparation of impure nicotinamide, and more recent studies with pure nicotinamide do not show signs of liver abnormalities. This is what I mean by studies have to be done with exact precision, even the smallest abnormality can bring up fallacious results and arguments. The other studies, the more recent ones actually showed that its hepatoprotective, beneficial for liver cells, and prevents toxic liver damage from carbon tetrachloride. Niacin do be dope. https://link.springer.com/content/pdf/10.1007%2Fs001250051536.pdf

With HPPD its really hard to say what the outcome will be, some people get to the point that they have relatively no noticeable symptoms, others do not, time really right now is the only way to tell. If you got it from a normal dose of wellbutrin though I would be amazing if you end up with permanent symptoms, I also will be amazed if your symptoms are even significant compared to typical cases of HPPD. How bad are your symptoms? Did you ever do drugs at all in the past, or while on wellbutrin?

It may take some time but it definitely will improve for sure. Thank you for reporting your case by the way im going to look farther in to wellbutrin on this.

Heres another study specifically for Niacin and its benefits for neuronal disorders more renowned than HPPD, but non the less give a good detail of its benefits for neurons. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412771/

Yah absolutely! Not offended at all. There probably are other options as well that could be beneficial for the condition, I just recommend niacin because from all the evidence I have seen it appears to me to be the best. Eventually when I have more time now that I know the underlying factors and etiology of the condition, I can better understand how to treat it, the study I just posted has some other good examples and explains why they are beneficial. So anyone can try them and see what works best! My only true concern at this point is how significant neuronal loss is in these conditions, as I understand it, I doubt that no neurons are lost, but if only 10,000 are lost, not so bad, but its millions are lost, it could result in being the epitome of the condition, rather than axonal damage, it should be well noted as well that in these conditions, axonal damage appears to last up to two years according to the study, so that pretty serious, but with proper treatments the time frame could be significantly reduced.

So in my post above, everyone can see what the cause of HPPD is. And I will try posting some more information about treatment options when I have more time. But for right now here is an awesome study, covering niacin, its effects on neurons, and other valuable vitamins as well that are extremely beneficial in neuron recovery. So I hope this helps people. Please try and let other people know about this thread and try and spread word about this. Thanks to everyone that has supported these threads. Here is the study. Also if anyone is wondering why some get HPPD, but some don't, that people with HPPD probably had at the time of hallucinogen use and underlying subclinical deficiency in certain antioxidants or vitamins in general, niacin deficiency even possibly being one of them(Pellagra), which would allow for higher susceptibility of mitochondrial dysfunction due to overstimulation and lead to higher amounts of axonal damage and neuronal loss. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966847/

Hello and welcome to the forums, you got HPPD from wellbutrin as well?

I posted it in my thread, The Cause of HPPD and Possible Treatments. You can find it there. There is definite evidence for neuronal damage, and possible neuronal loss.

No its great, I appreciate you're doing some research, but if you're going to get to the bottom of things you might as well go all the way. Straight to the point "Modern medical science said so" isn't proof of anything. I have literally half a billion examples of modern medicine being absolutely and atrociously wrong, I can prove it a multitude of various ways as well, but it continues to exhaust my time and energy trying to convince people that "because some guy with a degree told me so" isn't evidence of anything. Medicine knows everyone is just an average joe, like you said, and they know its a 4 trillion dollar market, that's a lot of money, with a lot of power. I have read thousands of studies, thoroughly, and understand them intimately on all sorts of levels, and I have found a multitude of false or inaccurate information. One of the articles mentions vitamin e and little effect, but I have other studies showing completely different. What people don't understand is with a hall a million dollars its easy to make a skewed study where they use too little of a dose, too little of a time period, or simply made poor observations, or studied one type of neuron, but not the same as the study showing results, then they claim fraud, quackery, snake oil and charge these men with ludicrous penalties fines fees jail time etc. There are hundreds of cases and doctors are even found dead of these ordeals quit often. Its 4 trillion dollars, try and tell me or anyone that 4 trillion dollars most men wouldn't kill for lol. But also its easily said as well that there are studies that show that Niacin does in fact work. I've also already mentioned the "liver damage" which is false as well, trumped up claims, and the studies for those were done with niacinamide not nicotinic acid(true niacin), so its not the same thing. Case in point "modern medicine said so" means nothing, show me real studies with proper doses and accurate time tables with viable patients, and then you have a solid argument. Hopefully all that makes sense. I can cite a million things they have said is "quackery" that is laughable as well, quackery, or maybe just beyond their understanding, beyond their ability to observe proper and accurate effects. The lack of intellect in men isn't evidence of "quackery" of the most genius minds of all time. Even the ray wand by Nikola Tesla is "quackery", or is it just so far beyond our comprehension that we leave it to that. I can argue chemotherapy is quackery, it scarcely works and when it does its usually annihilated the patients organs so profusely they die from multiple organ failure, it happens far more than they tell you. But treatments generate hundreds of billions of dollars. As for studies being corrupt as well, which is scary in my opinion, and sometimes I think its just lax nature of men, but I know of one published article in the national library of medicine that states vividly that vitamin d3 causes calcifications of tissues and goes on and on and on about all the evidence, its pages long. But I checked every study he references and not a single one uses cholecalciferol(d3), they all use a metabolite of d3 that is typically highly regulated by the body and it does in fact cause calcifications, however taking large doses of d3 scarcely raises the metabolite levels at all, and there are quite a few studies that show that vitamin d3 does the opposite, and at high doses reduces arterial stiffness by 10% in just a few months, which is monumental. Now the man in question that wrote the initial and inaccurate study, was he paid, is he desperate for work, is he simply lackadaisical, is he unfit for his position, is he afraid of reputational repercussions? These are all things to worry about and I see this in studies every so often. A lot have good accurate information, but you never hear about them in "Modern medical science" As for niacin I have, and you can easily find, hundreds of studies if you look that show that not only is it completely safe, but it does ameliorate mitochondrial dysfunction. I posted some of the studies as well. And if anyone doubts what I said, they need not question me or waste their time wondering, they can simply just look up what Linus Pauling says in his books on medicine, his quotes as well. Linus Pauling is the founder of orthomolecular medicine, he was a absolute genius, and won the noble prize twice for how great his works were. Ill listen to him over some group of mediocre money hungry doctors with a chip on their shoulder and an ego the size of Manhattan. The cause of HPPD found here. I also recently found a study as well that I will be posting soon that proves everything I am saying is accurate, the only hold back for now is that I'm trying to discern the degree of neuronal toxicity vs axonal damage as the doses in the study are quite high, and the neuronal death is very significant, its a very depressing study, but it gives all the answers as to how HPPD manifests, which is simply everything I have outlined, and the study says the same thing I have been talking about here in this thread. 5ht2a receptor agonists mediate neuronal stimulation to the point that they start overproducing free radicals, as abram hoffer says these radicals react with neurotransmitters, and this causes the hallucinations, in the study I am mentioning though, its strong doses as far as I can discern, but the free radical cascade results in severe mitochondrial damage, leading them to release caspase-3, resulting is apoptosis(neuronal suicide). So now its just discerning whether HPPD is most significantly from neuronal loss, or if it is more specifically axonal damage. That's HPPD, its that simple. Since the tests were in vitro though ill have to figure out how it translates to in vivo. If its only mitochondrial dysfunction and axonal damage, not only will niacin fix it, but it will be the best treatment that I know of to date. If Niacin doesn't work, its simply just a cascade of neuronal loss, most specific to the cortical neurons, and interneurons. And then everything is just a shit fuck. I suppose at this point I'll just post the study, and everyone can just read all this. Here is the study, if anyone says "but its MDMA" smack yourself and delete your post, the neuronal apoptosis, or death is mediated specifically via 5ht2a receptors, its also proven by 5ht2a receptor antagonist which block neuronal death. Its mainly in cortical neurons because they have the most dense amount of these receptors. This is main receptor all hallucinogens work on. 5ht2a Apoptosis.pdf

"An experiment in 2011-2012 administered a solution of C60 in olive oil to rats, achieving a major prolongation of their lifespan.[53] Since then, many oils with C60 have been sold as antioxidant products, but it does not avoid the problem of their sensitivity to light, that can turn them toxic. A later research confirmated that exposition to light degrades solutions of C60 in oil, making it toxic and leading to a 'massive' increase of the risk of developing cancer (tumors) after its consumption."[51][52] Should pretty much cover it I think, its an interesting compound, its probably via its electron affinity that it extends lifespan, Niacin extends lifespan in rat models as well, and it has no potential for toxicity, even when exposed to light.

Edit: I'm going to save this post for more reading, just to make sure my information is accurate.

In my defense I did leave useful information at the end lol. It is proven neurotoxicity, I have the studies that show its mediated directly through 5htp2a receptors, and its cortical neuron loss/neurotoxicity specifically, driven by caspase-3 apoptosis. Hallucinogens do cause permanent brain damage. Ill be making a thread on it pretty soon.

As far as I understand its predominately just an antimicrobial, its really good at it too, but sage is slightly better IMO, for antimicrobial effectiveness that is.

edit

To be entirely honest I haven't read much on PQQ, as far as I understand though it is good for mitochondria. Niacin right now is the best I have seen for mitochondria though. Better than CoQ10 even.