Fawkinchit

Well guys, I've pretty much figured it all out. This condition is actually quite simple as to the cause. I sometimes pray for an answer as to the cause, so that we can better understand the condition. Yesterday during my usual walk, I did the same. Last night I decided to do some quick reading and found 1 thing after another within a short amount of time and everything adds up. Researchers dont have any information on what hallucinogens do to the brain seemingly, but this isn't quite the case. We know for certain that take for example LSD, acts on 5ht2a receptors, we know this for sure because 5ht2a antagonists taken before LSD ingestion, will prevent hallucinations. As to the reason for the hallucinations they aren't quite sure, but they do know that 5ht2a activation exhibits increases in glutamate. Glutamate is the most available receptor in the brain, it also is notorious for excitotoxic apoptosis. The clear answer is that LSD and other hallucinogens increase neuronal output of glutamate, the hallucinations are probably from the overly excessive production of glutamate, and its stimulant effects. This is the cascade effect leading to overexcitation of neurons, and their eventual course to apoptosis, leading to the condition of HPPD. Now, some may argue that there are some who don't get HPPD, and that HPPD is rare. This is true, and creates a bit of elusiveness. The most possible reasons for this is that for one, many people are pretty complacent as to their actual cognitive function, and deficits created therein, this is one possible reason for less reports of HPPD. Granted however, I dont think this is the primary case for the rarity of HPPD, but rather, that glutamate requires breakdown, and utilizes P5P, or vitamin B6, for its breakdown with glutamate decarboxylase. Thus, the most probable explanation for HPPD is that the sufferers most likely have a variable amount of metabolic deficiency for the production of P5P or glutamate decarboxylase. This would explain why the condition is rare, and why some people come out seemingly unscathed by hallucinogens. I hardly doubt that they come out completely unscathed, but I am sure that their neuronal loss is most likely quite limited. The most likely explanation for MRIs having little to no findings is most probably due to the fact that the neuronal loss is scattered. Thus it will hardly show on MRIs, if at all, and this is why a small percentage actually do seem to have some minor findings of scattered white matter micro lesions, commonly associated with migraines. I'd like to comment too, that in my own personal case, the most likely cause for my HPPD was that I consistently, for years, would always take folinic acid, which I always noticed had a strong stimulant effect, not really knowing the reason for it however. Now I have found that folinic acid and other folate compounds are directly linked to the availability of free glutamate, hence during the use of hallucinogen use incombinate with high glutamate availability, you're going to be more prone to excitotoxicity leading to apoptosis and HPPD. Folate supplementation is also readily found in breads, and multivitamins. The cause for some people developing HPPD simply could be eating high amounts of folate in breads and grains unknowingly, and then taking hallucinogens, buffering glutamate production and excitotoxicity. Like I said, super simple, and easily explained. I should add too that people who experience recovery is due to neuronal plasticity. I'm not going to explain what that is here but its pretty simple to google and is pretty limited to the amount of recovery. From here I will try to find out if long distance axonal tracts can be repaired, if not even with neurogenesis and even stem cell research we will be limited to recovery based on that alone. Long distance axonal tracts are very important. As I've stated before, the Axolotl Salamander, who can regenerate large chunks of his brain, is incapable of repairing long distance axonal tracts after blunt trauma. This most certainly will inhibit functional regrowth of the brain. Also I'd like to add that the areas of the brain effected, are the cortico limbic systems. So frontal cortex, hipp, thalamus, etc. Heres a good read for understanding the limbic system https://www.interaction-design.org/literature/article/our-three-brains-the-emotional-brain. It all pretty much makes perfect sense. Heres for frontal lobe, https://en.wikipedia.org/wiki/Frontal_lobe#Function. Just skip to function and damage. I think we all will see a lot of our symptoms correlate or fall in to place in these areas of the brain.

Shit bros the more I read and learn the more confused I am. It could be so many things that cause HPPD. Some people do so much LSD and have zero symptoms after. I think that we must have some susceptibility, it may not even be brain damage. I was thinking that other possibilities could be allergic reaction related swelling causing microvascular ischemia in the brain, starving scattered neurons(neuronal loss). Another possibility really could be possible gene/DNA changes that create ion channel mutations, I dont know how it coiuld be that since it seems to come on over nice, but I did notice a progression in my symptoms from day one, so I dont know. But ion channel mutations could cause this. This is an impossible disease. Heres some stuff that ive found to be pretty interesting lately Posterior visual pathway cortical lesions (tumor,[1] abscess,[3] hemorrhage,[4] infarction,[1] arteriovenous malformation,[5]cortical dysplasia,[6] aneurysm[1]) and various seizure causes (hyperglycemia,[7] ion channel mutations,[8] Creutzfeldt–Jakob disease,[9] idiopathic seizures,[10] etc.) cause focal cortical hyperactivity or hyperexcitability, resulting in inappropriate, persistent activation of a visual memory circuit. Illusory palinopsia is a dysfunction of visual perception, resulting from diffuse, persistent alterations in neuronal excitability that affect physiological mechanisms of light or motion perception. Illusory palinopsia is caused by migraines, HPPD, prescription drugs, head trauma, or may be idiopathic. Trazodone,[11] nefazodone,[12] mirtazepine,[13] topiramate,[14]clomiphene,[15] oral contraceptives, and risperidone[16] have been reported to cause illusory palinopsia. A patient frequently has multiple types of illusory palinopsia, which represent dysfunctions in both light and motion perception. Light and motion are processed via different pathways, suggesting diffuse or global excitability alterations. https://en.wikipedia.org/wiki/Palinopsia This information could send us in an accurate general direction of whats going on here.

Id say were definitely masters of suffering. Bro can you please respond? Can you please post the video of the shaman or try to find it or give more details?

Go on........ Can you find the show again??

Heres a Danish study that did tests on 400 different people, 154 complained about long term problems years later. AKA HPPD sufferers. Some even committed suicide. And they lean toward potential neurotoxicity. "two-thirds of the patients had flashbacks." http://journals.sagepub.com/doi/10.1177/0957154X16629902

Haha, no not that long. Some may be pertaining to medicine. Ill see what I have when I have time.

Interesting. I may have some old German manuscripts that maybe you could help me understand? Might, its been a long time since I've looked at my non english stuff.

Most logical answer

Thats so weird, coffee wrecks me. Did you get your MRI results back yet?

Mgrade, nice to see you back.

Yes please do! You can read German??

Yah give a try and see what happens. The actual optic nerve itself probably has little to nothing to dow it’s HPPD though.

what about coffee?

Cool, they make mine terribly worse.

I couldn't see it having any long term negative effect, if anything the only potential I see is it having a stimulant effect that might exasperate your symptoms.

I haven't really tried CoQ10. I would be surprised if it helps, but really you never know. Vitamin D I know makes mine slightly worse if I drink to much Vitamin D milk. If you try the CoQ10 just start with like a quarter dose and work your way up. Never know what things are going to do.

Holy shit! This is an amazing find! Good post thats super weird. Im curious how the testing actually goes, like how this doctor tested these levels?

Yup! Well said! Thank you dayum_son.

I like how you apologize for you behavior, but then continue to berate me, you just cant help it can you? lmao

Show me where I implicated that. You did implicate that, "You don't have brain damage. You have anxiety." - TheMythos, anxiety is a predominate term used in medicine to distinguish a psychological issue, not physiological. Not only did you state its a non physiological problem, but you also promoted not addressing the physiological issue for a cure, which like I said, if it were cancer patients they would still die. Thus, HPPD victims, will still suffer even if they take your advice. So you have accomplished literally nothing. Nor do I ever expect you to. I dont claim to be a neuroscientist. Maybe they look up to me because im a contributing and progressive member of these forums, Something I STRONGLY recommend you take note of. I dont know if you have noticed, but I have 6 years and 28 pages worth of pure research, and honestly I've easily taken it farther that anyone I have seen. What have you done? Nothing? Honestly at this point Im not going to continue to argue with you. If you have something to actually contribute, to help members here and HPPD sufferers, please post, but so far is all you have done, still, is degrade and berate people.

Was that supposed to be clever? Im not impressed. You're trying though. Soon youll be able to read. ? I am a dude, bro.

Ok.... then why are you reading it???

I think you started with "go fuck yourself". Im amazed at ALL the proof you have to show. That was really convincing.

Again your comprehension fails you, no surprise, I never said PTSD wasn't a real disorder. Honestly can you even read?

My favorite part about these responses is you just berate everyone, but then completely fail to back ANYTHING you said or cover the flaws that were mentioned of your ridiculous theories. LMAO. Also you poor comprehension is extremely evident in most of what you say. To be completely honest, you haven't done a single thing productive in the research for HPPD, so you have literally no room to talk. Im easily aeons beyond you in understanding, you cant even see the flaws in your own reasoning, I dont think you can even see past your nose frankly. Based on everything you have had to say here, and your extremely negative derogatory and degenerative attitude, I dont think anyone appreciates you here on this forum. I can debase all the points you said easily, too easily, but I can tell you wont comprehend any of it, so I wont be wasting my time, I think the other members are fairly intelligent enough to see it for themselves. Especially the ones who actually make a progressive effort in trying to cure the disease, instead of ignoring it lmao.