onedayillsailagain

@BPC: Unfortunately that is quite hard without the extra electrodes (which must be purchased separately). I could attempt upside down. As for rTPJ stimulation.. not sure where I would leave the other electrodes, but I guess I could figure that out with a bit of searching. I've suspended tDCS for the moment. Last night, after boiling the suspension for the 3rd time, and letting it cool down, I gave it a another shot (pun intended). Crystals seemed to have formed on the wall of the glass I had boiled it in, indicating that not all was suspended in the injection water. But whatever. I withdrew the fluid, after which I swirled around another 5ml in the glass and withdrew that too. So I'm guessing the density was around 40mg/ml because I totalled at 15ml. Copied from an e-mail I sent this morning: However, I have also been experiencing intermittent odd heart sensations and overall tenseness; yet this could very well be a psychogenic anxiety response. Now, mentally, I'm not noticing any difference. As stated above; perhaps a higher dose is warranted. Meanwhile I got some D-AA in the mail, so if GLYX-13 doesn't work out, I'll start with that.

Moved topic to "Forum Questions and Suggestions" after reading OP's request.

@BPC: Yeah I've been meaning to read over that thread.. A lot of stuff I'm unfamiliar with and have trouble seeing connections to HPPD, albeit them being generally healthy concepts. Those oxygen therapies are indeed interesting; especially HBOT, however HBOT is rather expensive. I was actually looking at tanked oxygen after reading about HBOT, haha. Seems kind of like a waste of money though, unless it is indeed concentrated. That's an interesting note on CO2! @Visual: Hmm yes it does seem to be pointing towards (cerebral) vasodilation. Yes; that is correct, that's when I have brief relief. I haven't tried a sauna.. Always seems like unnecessary torture to me, haha. But I guess this does warrant further investigation in to vasodilation. Unfortunately, I've tried several cerebrovasodilators (vinpocetine, ginkgo biloba, that type of stuff), yet have not found relief with them. Perhaps they are not as potent as what is necessary. I'm also not sure how and if exactly cerebrovasodilatory effect is measured, and how one would go about comparing them. Taking regular vasodilators might upset ANS functioning, so that's out of the question. Any ideas?

http://www.youtube.com/watch?v=DFDEc8eIErw I took, I took your memories... Forced amnesia, an epiphany won't see ya.

Hmm.. I'm biased on this one. Recently, a lot of posts in noot forums have been popping up about it improving .. neuroplasticity it was? I don't recall, but it was a study where suddenly all participants had pitch perfect hearing after some training. In any case, there's a plethora of feedback about Valproic Acid indicating it's a potent nootlithic (thought I coined that term, turns out someone else did already ). Regardless of whether this is what sparked your interest, here's a more critical article. I would certainly advise against Valproic Acid. If you're looking for alternative GABAergics, Pregabilin and Gabapentin are worth looking in to. As for HDAC inhibitors, check out CL-994. I might try this one myself. Cheers!

Wishing you the best of luck!

Hey, since I've gotten worse, I've acquired a new symptom, eerily similar to what I've previously experienced on Iboga. I see these flashes of very thin blueish/grey lines travel rapidly across my keyboard sometimes, somewhat resembling a roster of sorts. Despite running across the outline of the keys, it feels/looks as if it is happening in close proximity to my eye. Anyhow, I wanted to look further in to this and why cocaine use may have initiated this new symptom, and compare to Iboga, as it is quite annoying. Would appreciate if anyone could remind me of the clinical term of these distortions, that is if there is any \ edit: They are not floaters or tracers. edit2; though I case they resemble tracers in a way. Why do visual distortion descriptions always sounds like "It has a certain Je ne sais quoi"?

Hehe yeah for sure I really need to find some good English rap

Yes, unfortunately it is.. I hope 60mg/ml is not too much / too dense for it to be absorbed by fatty tissue. On a side note; in the meantime I now have the foc.us headset, and have been using it. Unfortunately I have not yet been able to recreate my results from (I think it was) last year, where I saw significant -albeit temporary- relief. Though sleep does seem improved, primarily onset.

Hey guys, recently I've been having a hard time conjuring up new ideas for treatment approaches.. I frequently have orthostatic hypotension in varying severity, most likely due to being sedentary. However, more often than not, during the brief period that this occurs, I find significant to (near-)complete symptom relief, mainly of the DP/DR components. Sometimes I spaz and/or black out as well. Anyway, I was wondering what it could be that happens during orthostatic hypotension that could cause for this, more importantly can it be safely recreated in a prolonged manner? Haven't gone too deep in to it, but all I can imagine for now would be cerebral hypoxia, which of course is definitely not sustainable. However, the symptom relief usually comes right after the initial stage of "if I don't find something to hold on too I'm going to fall down" Perhaps then, it may be related to an overcompensation of cerebral oxygenation that I could imagine would follow suit to cerebral hypoxia. Hence, perhaps enhancing cerebral oxygenation may be something worth investigating? Then, of course, also cerebral blood flow may be involved; I was thinking Hydergine might be worth a try? Yes, this is conjecture, I'm grasping at straws, but hey; gotta entertain something right? Thoughts? On that note; have any of you come up with ideas lately? Cheers!

Thanks! AFAIK it's water-soluble. Hmm I had it standing in the sun for a bit, until I figured it might not be thermolabile yet vulnerable to UV, so I moved it out of the sun. Now I'm running CPUminer on my laptop to raise core temperature, thus output temperature, and the GLYX-13 is now at about ~37 degrees next to it. This better be worth melting my CPU StateOfRegret: The pore size was 0.2 micron. Indeed I figured because of this, it should've passed through, but apparently that is only the case for solutions.

So another update.. I've now heard from multiple sources that syringe filters are only suitable for aqueous solutions and not for suspensions. As such, I'm inclined to believe that my permeability tests were faulty. The question then remained; how to sterilize the GLYX-13 without a syringe filter? Apparently, after some discussion in #chemistry, small-chain peptides are not as thermolabile as I had assumed due to the storage recommendations of -20 Celsius. I was advised to use a rather old process, called tyndallization. It is a 3 day process which consists of boiling the solution once a day for 20 minutes. I've started this process today, so I'll be able to use it by Sunday. Also, apparently GLYX has been used in suspensions up to 60mg/ml http://download.cbsnews.com/media/2012/12/06/en_1206_lapook_1296.m4v At about 1:35 you can see this: Seeing this is what made me reconsider my approach. Anyway, hopefully I indeed injected only water the last time, and perhaps this time (provided the GLYX hasn't degraded due to high temperatures), it will work. I'll post updates once I've injected it.

Been doing some cryptocurrency trading lately.. This one is about Mt. Gox:

Relora is a mixture of Magnolia Officinalis bark, and Phellodendron Amurense bark. I forgot most about it, but from a quick glance it doesn't seem all that dangerous, especially if you don't take anything else with it. I've taken it myself for a while, but it did nothing for me; neither good nor bad. I don't see any reason why not to try it if you already have it.

Ahh yes this is an interesting one indeed. I've recommended it to someone with DP as an adjunct to his Phenelzine, because he gets alleviation from his symptoms from marijuana oddly enough. I suspected this to be due to the 5ht1a agonism of CBD.. If he ends up trying it, I'll be sure to ask him to make a post I can link. Not digging the NERT blocking too much though, although I forgot how to judge potencies from those numbers. I would try it, had I not been busy with many other approaches. But I wouldn't expect too much from it aside from perhaps non-sedating anxiolysis, perhaps slight nootropic and eugeroic effects. I'd say give it a whirl if you're not trying anything else currently. Are you planning to?

I'm already at the most efficacious dose currently. If I do any more this week, I will surpass that and efficacy will just diminish according to available data. However, I still have 600mg left. So I have some room for play, but I want to wait a week between dosing, because effects may be delayed up to 3 days. Especially considering our condition and suspected hypoactive NMDARs, it may require relatively higher doses to significantly activate them indeed. Alternatively, I could try daily "low" dosing. E.g. 1mg/kg/day, but I don't have enough filters to make fresh batches each day.

Well damnit. I feel no different. Perhaps the GLYX degraded because I left the solution out of the fridge for a day.. But to be honest, I don't think this is going to do anything revolutionary, not even small improvements. Alas.. Maybe NRX-1074 will be a more interesting compound, should Naurex ever decide to actually release its structure... There are a few factors I can think of that may have to do with the lack of efficacy, but ultimately I don't see much to be done about it. Either subcutaneous administration in humans is significantly and relatively less effective than animal models, or the compound was not GLYX, or whatever; no real way of knowing at this point. Could be individual difference; the other two people I bought it with haven't tried it yet, so let's see what they say when they do. Meanwhile I'm just gonna wait till next week, and try again. Hoping the three other substances I've on my list are gonna be more helpful.. JDTic, 7,8-DHF and EVP-6124. BTW: I'm open to suggestions!

Sorry to hear of your negative experience Missjess. Perhaps this was an individual sensitivity? Not to discredit your experience, but I'm hoping this is an anomaly amongst effects; everything indicates that it should do quite the opposite of what you experienced. That said, there are a myriad of reports of substances inducing opposite effects (e.g. Clonazepam improving cognition and motivation), so it's not impossible for this to happen. Despite that, I'll still be trying it. Although I do recommend, that indeed; anyone who's considering to try JDTic, would be best off heeding your warning and trying it in small (incremental) microgram doses first; this can be done by simply diluting it with water and a bit of math. Thank you Missjess for joining team Guinea Pig in our efforts to ameliorate drug induced disorders; it doesn't always play out positively apparently alas. I'm glad you're still ok and that it was only temporary. Hope you are doing well, odisa

Hey guys, infused 14ml of 20mg/ml GLYX-13 a few minutes ago. Damn this makes me anxious! Better be worth it I'll update tomorrow, cheers

Thanks guys! @@hppd24years haha probably a bit of both, with a hint of desperation. @@StateOfRegret, doses were tried from 1mg/kg to 30mg/kg, and 5mg/kg showed to be the most effective, so that's what I'm aiming for. I'll be doing a subcutaneous infusion of 300mg/15ml tonight, adding total dose to 5mg/kg. So that should become interesting. Re: antagonism, I've posted about that in the "Why NMDA anatagonism?" thread (pertaining to GLYX), if you're interested. So far I've not noticed anything yet (which is consistent with data indicating 1mg/kg is barely more effective than placebo). Anyways, I'll keep you guys updated!

http://www.sciencedirect.com/science/article/pii/S0028390814000598

Hey, long time no post. Still doing horrible. Nevermind that though. Anyways, managed to acquire some GLYX-13 from a reputable supplier. I tried a test dose of 60mg (20mg/ml 3ml) about an hour ago. Administration was done subcutaneously. Can't really say much about effects, cause I'm pretty anxious, but so far I'm still alive. Administration was more painful than IM Cerebrolysin, oddly enough. I think either I struck a nerve, or the substance is rather acidic. About to go to bed.. I'll try to update tomorrow. Depending on how I feel, I might do another 300mg. Cheers.

Hey, welcome to the forum! Hope you find what you're looking for. Advice #1: stay sober. Really just popped in to say; I like the avatar! Wish you the best, Odisa.

Upon further investigation, I found that GLYX-13 actually acts as an agonist at hypofunctional NMDARs, yet as an antagonist at NMDARs with higher activity. This is as close as I can imagine to NMDA modulation. I should have it next week, upon trial thereof I will open a new thread to log my experience. GLYX-13, a NMDAR glycine site functional partial agonist, induces antidepressant-like effects without Ketamine-like side-effects.

I'm very sorry to read of your experience.. How much did you take, and in what form? I don't have much too add unfortunately. My experience was a bad trip as well, however it was post-HPPD/DP and I never felt it made anything worse in the long run. It was out of desperation, and I knew little to nothing about pharmacology at the time. Iboga is a strong dissociative however (NMDAR antagonism + KOR agonism is the perfect dissociative cocktail). I did experience a few days of worsened symptoms, although they subsided back to baseline. I only took a threshold "flood" dose myself. I would go further in to my experience, but unfortunately much like yourself, substance (ab)use has lead to worsening of my condition and as such also memory. Though that was cocaine. Perhaps you may find my experience somewhere on these forums with the search function.. I barely remember ever doing it. Interestingly, what both cocaine and Iboga have in common, is increased KOR/dynorphin activation/gene expression, as do other common drugs of abuse that are reported to worsen HPPD/DP, despite having different MoA's. Are you currently taking any supplements/nootropics/medications aside from Lamotrigine? The Lamotrigine hypothesis is based off of the theory that NMDA antagonism causes the glutamate available in the brain to bind more at other glutamatergic receptors (for the glutamatergic NMDA is blocked), thus inducing dissociation (although there is no literature for glutamatergic agonistic dissociation documented, e.g. AMPA agonism hasn't been associated with said symptoms). Lamotrigine IIRC inhibits glutamate itself, thus making less available for these non-NMDA receptors, supposedly improving symptoms via this mechanism. The problem however with this method, is that you simultaneously leave less glutamate available for the NMDA receptor (glutamate also being an endogenous ligand aside from NMDA itself). Reduced NMDA activation is exactly what causes dissociative, cognitive, etc. symptoms in the first place, thus it sort of equals out any benefits gained (assuming the Lamotrigine theory is true to begin with). I suggest you try NMDA agonists. Currently available NMDA (partial and/or glycine site) agonists are Glycine, Sarcosine, D-Serine, D-cycloserine, D-Aspartic Acid. Discuss this with your doctor if you're interested and see if you can try one of those alongside Lamotrigine. Glutamate is a neurotransmitter that binds at many different receptors; inhibiting it is very non-specific whereas receptor modulation can pinpoint what works or doesn't. Anyway, hope that helps. Sorry if it's not clearly explained; foggy mind and all that. I wish you the very best and a speedy recovery. Odisa.