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Hallucinogen Persisting Perception Disorder (HPPD) Support Forum

yosoydiego

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  1. Felicia, I linked you drugs because you were looking for a "cure for HPPD", and those are the most reliable. That pursuit, mixed with your eagerness to find information, but yet your lack of skills to properly understand, interpret, and filter what you read, could be a really dangerous mix. Be careful, you're prone to fall into any type of dangerous shit... "sometimes longer" means a couple of hours more, not days, months, years, etc. Autophagy is a constant natural process. You could slightly stimulate it, but that's about it.
  2. Honestly, if you only have OEV, I'd just try to accept them, ignore them, etc. It seems like the general opinion is that that is the best. Stressing trying to find a "cure" that doesn't exists, could be way worse, stress is the worst. And adding more medications with its side effects, also worse. But that's just a bold opinion Best of luck anyway!
  3. "Stuck" for 12hs. Nothing to do with hppd. I hope you're referring to "autophagy" as the process that happens naturally in our bodies, and not to actually doing it consciously on a macro level... 🤣 Some anecdotes have reported benefits with more or less extreme diets or exercise... but anecdotes. if you want to give it a try, go ahead, but keep it SAFE! Some supplements that might help: https://www.reddit.com/r/HPPD/comments/aqzv06/lions_manenaccholinemagnesium/ Some prescription drugs that might help: http://hppdonline.com/topic/6012-most-commonly-used-medications/
  4. Both Haloperidol and risperidone have worked for some people, although be aware that many report some worsening of symptoms at the beginning of the treatment I guess Keppra helped with DP/DR, but not with open eye visuals?
  5. "up to 12 hours" LSD is always fully cleared from your system, although it might take slightly longer than for most other drugs, but it has nothing to do with hppd..
  6. Treatment with the atypical antipsychotic medications paliperidone and risperidone normalized basal extracellular glutamate https://www.ncbi.nlm.nih.gov/pubmed/21699956 In line with my other post
  7. I think that you're lucky to enjoy your hppd, and to have the photoshop skills to show it to the rest! If you turn around, not facing the sun, I guess they are gone? In that case, it would be shadows.
  8. To keep it more ordered, I've created a whole topic replying to that: http://hppdonline.com/topic/6791-hppd-is-not-serotonergic-in-nature/
  9. I should add the prefix to the subject: "Why I think that", but it would be too long. Consider it added. I'll elaborate some points and quote some sources, but note that many more sources can be found, the conclusion is not based on these sources only. Note that I'll make a conceptual leap: since basically nothing can be said about HPPD due to lack of research and data, I'll treat it as some form of psychosis/schizophrenia, which is widely studied (although not understood anyway), and REMARKABLY similar to HPPD. At the very least, it could be said that HPPD is a mild form of psychosis/schizophrenia, a subset, etc, but it seems very logical to assume that they will share many characteristics. See second link, about Drug Induced Psychosis - The causes of schizophrenia are not understood, and many hypothesis have been proposed, notably: serotonergic causes, dopaminergic causes, and glutamate causes. While the sertonergic idea is the older, newer studies point in other directions, mainly of stimulatory nature https://link.springer.com/chapter/10.1007/978-1-4684-8228-7_17 https://www.researchgate.net/publication/314031343_Drug_Abuse_and_Psychosis_New_Insights_into_Drug-induced_Psychosis - Recent studies have indicated the importance of the Dopaminergic system in the effects of LSD, distinguishing between phases of the LSD effects according to the main receptors activated, and proposing as a model for schizophrenia. https://www.ncbi.nlm.nih.gov/m/pubmed/21352832 https://www.ncbi.nlm.nih.gov/pubmed/15723230 - While sertonergic system is mainly associated with mood (depression, anti-depressants), the Glutamate system is more related with the information processing and memory formation. - The relationship between dopamine and glutamate is deep, and many studies are studying their link to each other, and to psychosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162342/ https://www.ncbi.nlm.nih.gov/pubmed/24524997 https://www.nature.com/articles/s41398-017-0071-9 - Going back to David Nichols study about the 2 different phases (sertonergic and dopaminergic) phases of LSD, and comparing that to the description of HPPD, seems clear that HPPD seems more "phase 2". It's usually describe as "the last part of an LSD trip" - For drugs or situations that are well known to trigger or worsen HPPD according to the community, it can be found that they act on the dopamine/glutamate system, but NOT (or barely) on the sertonergic system. -- coffee -- stress -- cocaine - The inverse argument can be seen also: drugs that act directly on the serotonergic system, usually have little effect on HPPD, or make it even worse. Example: anti-depressants (SSRI). Also, the same drugs are not known to cause HPPD. - Of the drugs that have consistently shown usefulness for the HPPD community, 2 of the 4 target the Glutamate system https://www.reddit.com/r/HPPD/comments/aqzv06/lions_manenaccholinemagnesium/ - Some HPPD sufferers are experimenting with Ketamine, with good results. Ketamine's main method of action is through the Glutamate system, not serotonin. - Regarding stress being a trigger for HPPD, the relationship between cortisol and glutamate and PTSD has been already treated, in this example, by no less than David Nutt, one of the most world renowned scientists regarding drugs: https://www.ncbi.nlm.nih.gov/pubmed/18701640 - More about the relationship of psychedelics, anti-psychotics, and 5HT2A and Glutamate receptors can be seen here: http://blogs.discovermagazine.com/neuroskeptic/2011/12/03/a-psychedelic-tale-of-two-neurotransmitters/#.XaWgWHj5WHs - More on the relationship of excess glutamate in the PFC and schizophrenia: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107933/ https://www.ncbi.nlm.nih.gov/pubmed/16860780/ - Chronic LSD, schizophrenia, glutamate, etc: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110609/ In sum, for all of the above, I believe it's pretty clear that HPPD has way bigger chances of being glutamate related, than serotonin related. I could also keep going on a bit more about in the hypothesis, but I'll leave that for a follow up text. Looking forward to reading all opinions. Cheers!
  10. Although I'm up for "original" ideas, I just don't think that 5-HT is involved at all, for many many reasons.
  11. Thanks for the reply, although the first reply means that I didn't express myself properly: we're definitely NOT taking any drugs at all. A month and a half now, with a ton of pills (lion's mane, gingko, magnesium, etc etc), but no drugs, caffeine, etc. Sleep got much much better. My girlfriend's CEV got better too, although a bout of stress last week brought them back for the night, which means we're not in the clear yet. I'm still researching. 😞
  12. UP with this: https://www.reddit.com/r/HPPD/comments/dghfbx/ketogenic_diet_for_hppd/
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