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David S. Kozin

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Everything posted by David S. Kozin

  1. "Characterization, Frequency and Severity of Visual Phenomenology in Adults with Hallucinogen Persisting Perception Disorder" Name and address of the principal investigator David S. Kozin, Site where the study will be performed: Online. The study will be carried out at the office of the principal investigator with 256-bit SSL encrypted server access. Introduction Hallucinogen Persisting Perception Disorder (HPPD) is a persisting, post-substance use disorder characterized by the diagnostic criterion of “the re-experiencing, following cessation of use of a hallucinogen, of one or more of the perceptual symptoms that were experienced while intoxicated with the hallucinogen (e.g., geometric hallucinations, false perceptions of movement in the peripheral visual fields, flashes of colors, intensified colors, trails of images of moving objects, positive afterimages, halos around objects, macropsia, and micropsia.” (DSM-5 (update definition)). Abraham (1993) completed the most complete characterization of symptoms Additionally, individuals reporting HPPD and anecdotal evidence from online support message boards suggest that a prominent portion of this population presents symptoms of depersonalization disorder and derealization without clinical memory or identity alterations typically present in other dissociative disorders (Simeon & Kozin et al, unpublished data). The course of HPPD with the most significant distress is typically chronic and continuous (Lerner et al. 2002 & online descriptions), however the DSM-5 (update definition) does not differentiate between the chronic and transient forms of perceptual disturbances as independent diagnostic entities (APA 2004). HPPD often lasts for years and often individuals with significant symptom severity with have the disorder for over 30 years and likely will not end until the end of their lives. The triggering of the visual symptoms does not always occur immediately after the precipitant drug, but has been been reported to be associated either with trauma (self-reports) or a non-hallucinogenic drug is the precipitant, or increases symptoms (Alcántra, (1998), Favazza & Domino (1969), Lauterbach et al (2000) , Lerner et al (2002), Markel et al (1994), Morehead & Morehead (1997), Scott (1971), & Solhkhah (2000), unpublished online reports). Dr. Roger Davis and David Kozin created a complete set of visual simulators for the symptoms described in Abraham’s 1983 symptom list. Davis and Kozin used images from individuals from an online HPPD community and completed a one week session where each visual simulator we presented to a live audience of individuals from the HPPD online community to constantly discuss with Davis and Kozin regarding the accuracy of each image. Ultimately, we need a catalogue of HPPD visual disturbances and these simulators are able to be included as tools within the survey. This could help develop an online catalogue where each "plate" in the represents a reference point through which patients can explain their vision to mental health professionals and other doctors. Unfortunately, at this point we we do not have a systematic and objective result from participants on their responses to these images. Eventually, the entire catalog of simulators could be distributed online for clinical consumption for doctors to help them understand HPPD perceptual disturbances, acquainting them with the disorder, and perhaps averting tragedies where, for example, HPPD patients are misdiagnosed with schizophrenia and given antipsychotic drugs that can worsen the disorder. It is the goal of this survey to descriptively and systematically study in greater depth the frequency, duration, and severity of the visual symptoms of HPPD, the relationship between illicit and non-illicit drug use and HPPD-like symptoms, investigate other additional possible psychopathologies with valid instruments and/or self-report, and to investigate the differences between chronic and transient subtypes. In light of the DSM-V’s goal of a dimensional approach to diagnosis, and also to not make the mistake of the DSM-III and IV to sacrifice validity over stability (personal communications with APA Task Force members during the ISSTD conference), a study that helps identify and improve diagnostic precision for these persisting drug-induced experiences, either transient or chronic, will help with choosing treatments and improving and clarifying research with improved definitions to match the variability in these disorders. This will improve the validity of the diagnosis, and lead to proper treatments associated with each subtype. Mood, anxiety and personality disorders are often comorbid with HPPD, but none have been examined to predict symptom severity. The most common proximal precipitants of the disorder are hallucinogens (specifically HPPD), however non-hallucinogens have been reported to cause similar symptoms. These will be investigated by allowing non-hallucinogen users to participate if they match the visual symptom criteria and including a standard scale to measure mood and anxiety. Axis II disorders will unlikely be able to be examined within the time-frame anticipated for this study. Reports from online forums for people with HPPD (such as the forum at http://www.hppdonline.com) and clinical experience suggests that: 1) The current DSM-5 (update definition) diagnosis for HPPD encompassed two disorders that have distinctly different etiologies and treatment responses, the clinical community lacks awareness of the complexity of this disorder (indicated by textbooks often referring only to the transient “flashback” type [examples are available]), and researchers reporting HPPD case studies often fail to mention chronic HPPD, and although treatments listed in the literature may be successful for flashback type, they are not proven to be successful in the chronic type – this could lead to unnecessary medication treatments for individuals with HPPD and increased cost of their health care. Potential subjects for this study, unsolicited and written in a public forum, often report on the message board or personal communication that the DSM-5 (update definition)’s inclusiveness of the phrase “flashbacks” in the name of the diagnosis as well as the often mis-use of the word in the literature has resulted in the clinician treating a chronic HPPD patient as one with temporary flashbacks resulting in the patient leaving therapy and not returning and feeling discouraged. Research Objectives and Hypothesis The purpose of this study is to investigate if the current definition of Hallucinogen Persisting Perception Disorder, excluding the criterion of the DSM-5 (update definition) requiring hallucinogen use, to produce multiple groups and to characterize the symptoms, comorbid disorders, and serve as the largest systematic study of HPPD participants to date. The study will gather accounts of people with vision problems not caused from hallucinogens and to investigate visual symptoms from drugs that have been reported in the literature. The hypothesis is that the current diagnosis truly encompasses two distinct sub types, and dimensional scales measuring the frequency, severity, and treatment responses will create two clusters within the current diagnosis. Study Design and Research Methods This survey will be posted on the internet, and we expect to recruit 200 participants over a 6-month period. Only individuals over the age of 18 will be eligible to take part. To expedite IRB review, one method would be to make the survey anonymous and protect the privacy of the participants by not inquiring about any identifying demographics, such as name, date of birth, address, or phone numbers, nor submission of e-mail addresses. However, including an initial phone interview, which could be done without recording personal data, could be set-up with the current survey software to have an initial interview over the phone and providing a unique “token” to an individual to ensure non-repeaters and help increase the potential that the participants do fit within our qualifications of having visual symptoms to those defined in HPPD. In this latter format, a participant will be able to take part in the study by contacting the laboratory by phone or e-mail, and afterwards the participant receive a token which will be activated after one day. When the 24 hours from the receipt of the token have elapsed, participants will be able to enter the survey page, enter their token information, and begin the survey. Upon completion of the survey, each token will no longer be useable and the participants will be debriefed. Subjects will be recruited through HPPD related websites , other Internet forums related to drug-use, potentially advertised, and will require the participant to complete an online consent form. Subjects will submit an online consent statement and questionnaire with questions on 1. Demographic information 2. A list of questions structured to diagnose HPPD based on DSM-5 (update definition) criteria 3. Drug History, past and current. 4. Using dimensional scales to rate frequency, duration, and severity of visual symptoms. questions will inquire about the disorder in-depth based on the information collected both in the literature and also using language collected from the community from the on-line support message board (Symptoms Descriptions and Stories from public forum are listed below). 6. Effects of treatments with self-reported measures of their effectiveness using the standard 7-point ical Global Impression – Improvement Scale (CGI-I) 8. The Sheehan Disability Scale will be administered. If the participant answers questions consistent with the DES, then they will be branched to take the Cambridge Depersonalization Scale. 7. Allow for a free-text description of symptoms and story for clinical narratives. 8. Include vision simulators and images for judging accuracy of these items. Regarding the survey design and my discussions with Roger Davis, in terms of the psychometrics, we would consider using the Rasch model to derive the scales with the goal of leading to uni-dimensional scales with a good distribution of item difficulties, this will be necessary to quantify the disorder well at every point along its severity. We don't want to end up with scales that measure the disorder only at the more severe levels. Once we reach this point, we'll have a set of scales that could potentially be used in a next step for validation to be used by the individual clinician to assess an HPPD patient and be used by a researcher who wants to further investigate the syndrome (creating a uniform HPPD diagnosis versus the current variants of language in the literature where clinicians are using the same words to imply different syndromes). I believe this would be a reasonable first step, and also would produce a publication that allows for an updated review of HPPD. I realize that the DSM-III and IV sacrificed validity for reliability. In my opinion, moving back towards empirical research, it could be useful in discussing the possibility for suggesting (aligned with Lerner's publication and what we see online and in clinical settings) the consideration of lobbying for two subtypes of HPPD: transient flashbacks and continuous/chronic. Although I realize the knowledgeable clinician should consider this diagnosis correctly, we have seen in the literature the amount of flashback case studies, undifferentiated from chronic HPPD, eventually find homes in the pages of medical web sites and textbooks that characterize HPPD solely based on HPPD of the flashback variety. I have read many stories from HPPD'rs where this has caused considerable difficulty when trying to explain to the clinician the suffering caused from full-time perceptual disturbances and needing treatment to deal with their concern for its potential permanence; this often goes invalidated by the clinician because of the word "Flashbacks" associated with HPPD in the DSM-5. The database of responses will be stored indefinitely in a locked filing cabinet. Data extracted will be stored in an SPSS data file, MySQL db, and Excel spreadsheet file saved on computers in the locked office of the principal investigator (same location). Women and minorities will be included. Based on registration, members of online support message boards for HPPD are more often males, so we anticipate considerably greater participation among males (HPPDonline.com statistics). Subjects will not be audio- or videotaped. Subjects will not receive any payment for participation. There are no potential risks to the subjects from participation in this study except for potential loss of confidentiality regarding their medical condition, which we minimize by keeping medical records in a locked filing cabinet in a locked office in a locked building. There are no direct benefits to the individual subject, nor is compensation provided for participation; however, the subject and society may benefit indirectly if this study leads to greater understanding of HPPD. Descriptive statistics, two-sample comparisons between transient and chronic cases, and an exploratory factor analysis will be used to evaluate data collated from the survey. Dr. Roger Davis has agreed to help with question and study design and pilot testing the study with students in his graduate-level class on “Methodology of Psychometric Instrument Design”. Anticipated Results and Potential Pitfalls We expect the results will yield two psychometrically valid, clinically meaningful, and possibly conceptually discrete underlying dimensions of Hallucinogen Persisting Perception Disorder. Therefore, the derived frequency and symptom sets are well suited for a prospective field trial study using an adapted structured interview in an effort to derive clinically useful diagnostic criteria for HPPD for the DSM-V. We may also find evidence of positive and negative treatment self-reports dependent on subtype (for instance, greater efficacy of clonazepam for symptom reduction in chronic sub-type over periodic.) Pitfalls include that the survey precludes face-to-face diagnostics for Axis I disorders and is retrospective in nature,; however, methodological shortcomings are well recognized and characteristic of Internet-based surveys with self-referral. However, selection bias is minimized by including and advertising on targeted web sites to include individuals reporting to fit in the diagnosis and including questions designed to target individuals likely to be exaggerating symptoms, and possible inclusion of other validated scales. Additionally, using the initial phone inclusion method could help reduce common problems with online surveys. A prior online survey yielded strikingly similar results on standardized scales compared to those including diagnositics (Simeon & Kozin et al 2008 & Simeon & Kozin et al 2009) Discussion of Next Steps If acute and chronic types do form two distinct quantitatively valid subtypes, then two-sample comparisons between both groups and also between the hallucinogen-induced and non-hallucinogen induced groups will help will provide evidence for the difference between these groups and lead to an improved diagnosis that will follow in the spirit of the new DSM-V of designing diagnoses with the goal of ultimately benefiting the patient and lead to improved clarity of diagnosis for improved research. The study would score severity and frequency and seek a possible dimensional model for symptom descriptions, uncovering an effective HPPD symptom lexicon that should be shared with neurologists, ophthalmologists, and mental health professionals. Defining the perceptual disturbances with unified symptom descriptions within the disorder will improve the precision of the diagnosis and lead to improved treatment methods.
  2. HPPD STUDY IDEA: Prepulse Inhibition Study and Event-related Oscillations from Evoked Potentials: (P300 EEG, EMG & ERP) Mid-latency evoked responses are so designated to differentiate them from the earlier sensory potentials and later ERPs that are more affected by cognitive processing. The ERP measures that appear most important are the three most examined midlatency components in the auditory modality that are designated P50 (a positive component occurring between 35 and 80 ms after stimulus onset), N100 (a negative component occurring between 80 and 150 ms after stimulus onset), and P200 (a positive component occurring between 150 and 250 ms after stimulus onset). These components share the characteristic that their amplitude decreases with repetition (habituation or sensory gating). The P50 and N100 components have been studied extensively in psychiatric patients. Sensory gating of P50 is a potentially useful endophenotype of psychosis or latent psychosis. Evidence for an inhibitory abnormality (i.e., sensory gating deficit) in schizophrenic patients has been around for almost 25 years. The magnitude of the deficit is similar to the most robust findings reported in neuroimaging and neuropsychology in schizophrenia. The N100 electrode component has also been recently shown to exhibit a similar deficit in habituation in schizophrenic patients. It is now firmly established that anomalies in the P300 response are associated with a wide variety of psychiatric conditions, including substance abuse. It has repeatedly been shown that the offspring of alcoholics demonstrate P300 amplitude reduction despite their lack of exposure to alcohol, thus suggesting that this anomaly is an endophenotype tapping the underlying genetic risk for alcoholism. Research with this putative endophenotype also is helping to explain patterns of psychiatric comorbidity often observed with other substance use disorders. To the extent that amplitude reduction indexes underlying genetic risk, the pattern observed in the figure is consistent with the hypothesis that the covariation among these disorders reflects shared genetic influences. There is ample evidence to support this notion, including twin and family studies showing that shared genes account for most of the covariance among these disorders. Consistent with the notion that P300 provides a neurobiological representation of the underlying genetic risk, P300 amplitude also covaries with these disinhibitory disorders, with shared genes accounting for the association. Because ERPs are derived from the EEG, it is possible to use time frequency analysis to identify the constituent EEG waves, which, because they are time locked to the stimulus presentation, compose the ERP waveform. This type of analysis makes it possible to determine the amount of each EEG frequency present at each point in time elapsing from the onset of a stimulus to the resolution of the associated ERP. These event-related oscillations (EROs) can be partitioned into the same frequency bands identified for spontaneous EEG, but these stimulus-elicited rhythms are likely to be functionally different from the frequency bands that compose resting EEG. With respect to P300, specific neural activity have different responses during elicitation of P300. Event-related oscillations also are beginning to provide insights regarding brain dynamics and psychopathology, especially regarding the development of drug dependence. Reduced delta and theta EROs have been associated with risk for the development of alcoholism over and above the risk associated with reduced P300 amplitude, suggesting that they add important predictive information not tapped by measures of the P300 endophenotype. These EROs have been linked to gene variants involved in cholinergic and GABAergic neurotransmitter systems, systems that have been implicated in the neurochemical pathways involved in substance use and P300 generation. Collectively, this line of ERP/ERO research highlights the evolving potential of electrophysiological correlates of human information processing to identify those at genetic risk for the development of alcoholism and related comorbidities.
  3. Gamma-aminobutyric acid-ergic deficits might increase the vulnerability to the psychotomimetic and perceptual altering effects of serotonergic agents. These data suggest that interactions between GABAA and 5-HT systems might contribute to the pathophysiology of psychosis and dissociative-like perceptual states.
  4. David S. Kozin

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  5. DISCLAIMER: My ex-girlfriend was advised by her money manager not to put $25,000 into my suggestion to buy stock in the company that was testing this drug. It was October 2012, and it was $2.00. She didn't tell me she was going to buy some, she did it on her own in case it went down to $1.000 and she lost money. (Great Girlfriend, I know). Money Manager guy said it was not wise. She decided not to. I sent a facebook message to close family members. Nobody would listen, and I have given 2 stock suggestions in my life: Netflix, NVIDIA (in 2008, whenever it split twice in Feb). I explained why I was so certain it was going to pop. On my public Twitter account, I recommended it at 2.00. then at $4. $7. $9-11. All publicly, but I had no money and didn't realize how easy it would be to set up an investment account or I would have put at least 500 dollars in by selling everything I owned. The 25,000 would have bought 12,500 shares and two years later was worth $500,000‬. My family wishes they listened. So... I have been watching ACADIA since 2012, and although I had no money I recommended to wealthy family members and others to buy it at $2.00. I even publicly posted why. You can understand why it would appear on my radar right after finishing my degree and working on theoretical models and potential targets and I saw this. I have not stopped watching ACADIA, and later did own stock option calls and because of financial issues sold them. This is a very interesting drug. I knew it was going to get approved because the FDA needed a drug for Parkinson's, but I knew this was not the ultimate goal. The ultimate goal of a pharmaceutical company is to open up to a big market. Parkinsons as a target made it receive fast track status because no existing treatment for PD. Big institutional investors started getting in. Risperdal causes issues (theorized and along with Yale's Souza lab and others in similar human research) that unlike regular schizophrenia, where these atypical antipsychotics block 5-HT2A sites, which means that in the one system we often talk about that has 5-HT2A inputs to produce GABA inhibitory signals would mean LESS GABA inhibition, the drug addressed both this and new method for working on the DOPAMINE system where the COMT theories and other targets for HPPD were coming out. I designed a protocol study for HPPD using a pre-pulse inhibition design. I wrote out my theory for why this test would be useful and it ends there. I actually thought that it would be less helpful for pure HPPD visual symptoms, but most helpful for Depersonalization and Derealization symptoms. Maybe one day, we can get that study moving. But, I have been linked to this drug for a long time, and I would like to see something come out of it. Don't believe the CNN hype articles, they were manipulation stories that are part of biotech investments .
  6. It might make a useful post now. Unfinished. It can be your call. If you think helpful, then unhide it all and keep the conversation. One major step I worked to change is my ability to let go and trust others. Night!
  7. I was rambling on, and then wanted a break and to come back to it. It is perfectly fine to comment. ") it gives a good look into my brain I think. Also, if I am going to discuss something that may put me in a precarious situation, I just hide it and come back to it later. People with different learning styles or challenges in traditional classrooms or learning disorders are represented in a higher percentage than normal groups. This is Dr. Abraham's experience and I agreed. My qEEG and more specifically Dr. Frank Duffy's impression of my EEG back in 1999 is classic ADHD now. My front and central cortex has "astroundly high" amplitude for theta broadly across the region and even working on task, I am in this.high theta state. Of course, this is a state that monks are measured at achieving and people seek to reach this point with meditation. I can lucid dream almost at willner night if I thing about it for a few days. I can also see unusual connections in things and it has made what should have been an extremely lucrative stock trader. Howtoadhd in YouTube is a beautiful spirit with ADHD that has an wonderful channel she developed and has recently had other groups visiting on her channel. I'll post something about this soon enough, but it may be a video. Oh yes, my one point: more people with HPPD have these conditions, but do students feeling they are not working up to their own standards at school or life and are frustrated tend to take hallucinogens more than neurotypical and this is why the prevalence. I take Adderall for it, and it is a life changer. I was in tears at all the first. I finally graduated college in 2011 after starting in 1996 and having three publications in the interim. But in 2008 I read a book without skipping pages. I am celebrating that Inhave not missed a doctor or dental appointment in one year using my Bullet Journal, which I treat with every reverence. I would miss final exams and appointments routinely and it could be written on my hand. Ok, I have had trouble sleeping ever since I took a drop from 4 to 2mg of Klonopin recently and punctuated it with 7 days of klonopin free. I was in a safe space, so now I am trying 2mg and the day goes well, but sleep is not. This includes.that I have gabapentin to help. 20 years of benzos will definitely change expression of receptors, but I think we are much more resilient than we give ourselves credit for. - dk
  8. Mad Doc gives great advice. I can tell you that your choice of grammar for your post's subject already tells me -- I am recalling many years of people giving an introduction -- you said something that puts you in a group that has the best outlook. What is it? You used exclamation marks, but just to say Hi. Not like "My life is ending!!!" But "New Here!!" It may seem like a small observation, but if I have to make a judgement this is telling. It goes along with how well you are doing for your time frame and this is a great indicator. - dk
  9. Hi Thomz, I wish I could give you a great answer, but I can try and be reassuring and if you can tell more than it could help, but ultimately it will be you and a doctor that makes that decision. 1) Yes, the symptoms of HPPD may not appear until later in life, but typically it is much sooner than later. Also, research and personal experiences are pretty clear that alcohol is not a common if almost never a drug that starts HPPD after hallucinogen use. 2) Visual Disorders that share very similar symptoms, but the individuals have never taken a hallucinogen inside Visual Snow (this name is misleading, as the symptoms can include much more than the static snow symptom). Other disorders are best rule out by a Neurologist, but just to be complete with my answer I will mention Temporal Lobe Epilepsy. 3) Most people with HPPD will not question whether they have it or not after they have read the list of symptoms. It is such a shocking experience to hear someone talking about having their walls moving in the side of their vision but they never go anywhere or one day have perfect vision and the next day and beyond have blurred vision. I hope that helps
  10. I was going to write an introduction, etc. I don't have the energy now, but I do think it is VERY important that people with HPPD learn the truth about the amount of information that has existed out in the academic literature and why it frankly pisses me off that some researchers see that since 1969 there has been a stable disorder of symptoms that account for our condition, but they ignore it or don't have the time or desire to invest in researching what came before. I have read over 100 articles for my undergraduate thesis, and luckily had access to all of the databases I needed. So, I was privileged . Ii want to share that with you. I want to do these in videos, but I haven't set that up yet. So, here is the first major paper on HPPD that literally covers every major point and gets it right: Copy of horowitz_flashbacks (1).pdfCopy of horowitz_flashbacks (1).pdf
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  16. Hi viewers. I would guess that many members have never experienced having me on the message board. A confluence of events occured that forced me away, and it has been hard to return. Why you should read this because it will be a thread that will include information I never discussed before, I will provide information that had been withheld and I will open up the work I did that has been reviewed by members of Senior Commitees in the APA and senior researchers at Yale. They thought the research ideas where quite valuable. My first admissions: When my HPPD started and I developed panic attack disorder and was put on a high dose of Klonopin. For the last 10 years, I have been on 4mg a day. A doctor finally had me tested, and I knew I have struggled with organization and my ability to control how I concentrate, and it was so severe I almost didnt graduate from High School, yet I slipped by as National Honor Society Preside t even though I failed all marling of Spanish, Calculus, Basic Accounting and Government. I took 6 hours of tests. Part of the interesting parts are that I write essays at a 5th grade level when forced to use a pencil and paper. This was a strong contrast to my academic publications and the rest of my testing. The other area that surprised me, was that I scored in the SEVERLY IMPAIRED Hagen, Moore, Wickham, and Maples (2008) found that children who have trouble with visual skills have difficulty with attention, which interferes with executive brain functioning and mimics ADHD symptoms. Children with VPD may be easily distracted by too much visual stimulation.
  17. I have a research study protocol designed to test aspects of this. The brain handles the compensation of the excess signals to help you adapt to your environment. First, wearing Sunglasses is one of the great pieces of advice that I cant stress enough. Blue blockers and anti glare can reduce the amount of stimuli reaching your eye, which dampens the range of signal strength you brain has to process For example, a Strobe Light in a Dark Space is AWFUL. This is from the rapid cycling of strong on signal and off signal. In bright Sunlight, when I am reading a book with the Sun against my back, on many occasions the black text turned green as bright green ink. Some users hate the darkness, and the reason is similar in theory. When the brain is not receiving visual information, if it expects something or is overactive it will create images and/or this is a time it is easiest to focus k the symptoms. I would cry, and beg just to see a plain black wall. As it stands, I am not counting on that happening, but this is one line of research I whole like to explore. Copy of kozin 8032B.pdf This is one invoice for a purchase I was readying for research.
  18. Since it started, I thought the Nationbuilder system had some very unique things that can work with another system to create a very effective tool for generating interest, policy and awareness with a very powerful human and other management side. It worked for the Prime Minister of New Zealand, and many large non profits are switching over. It enables EU privacy rules downloadable information files and because it is used election sites it is very conscious about security. I am currently testing just a simple sign up system, which will ask for a phone number and an address, the phone number is mandatory, and it will let you know I will be in touch with you. We could also make it where it could sign someone up for events, get information. In the backend, someone texting the message to this main number will have an account created, and I have a dashboard of tasks to do and it will pop up I need to contact you. I set up auto tags so I know supporters, it can set up memberships, be useful for doctor recommendations or even send a phone text alert if research or a social group is set up in your region (maybe a 100 mile radius). It works world wide. It can collect money, but full disclosure is that it goes straight to my bank account. I used to have a seperate 501(c)(3) but dissolved it after the research and life happened. So, if you want to just test the basic system, I also have it set up to give any user 12 months of free "Subscriber" level membership. Again, full disclosure, this is essentially had no meaning at this point, and I never wanted to offer people unable to pay for services any denied services, but it could mean that my library of documents that cost money can be accessed with a controlled system. The themes use liquid and are rather simple. I was an ASP and C programmer back in 1996 and then did PHP with a MySQL server and designed a research system to pass Mt. Sinai School of Medicine New York IRB requirements and successfully had 384 participants and is currently one of the most cited papers for DPD diagnostic criteria (almost or over 100 citations) and we did it without a budget. Here is the test signup text: Text HELP to +17346071765 to be an early tester or the contact system. I will call you back within 2 days and explain much more. For donations, until I point a domain to the site we have only the subdomain. I own eyedisorders.org, hppdonline.com, and perceptualpsychology.com. If you are interested learning more, and about what server host I prefer to use if not this place and the VPS and other plans they have and mu history with them I can point you in that way. Knowing the best way to have OPENauthentication so the systems are happy communicating but without forcing Twitter or Facebook accounts is a big goal. I need people to help support me, and I had a major break through in my personal life and am down in my meds and grad school is next goal and I have new protocols for visual neuroscience and imaging testing. Also, epidemiological tests. There are very smart people on here, and very capable people that can do everything from missile guidance systems, very prestigious attorneys and software folk. Time to get back in the saddle --- just so much bad information -- and we should control our story. https://davidkozin.nationbuilder.com/early_donors Current design: Also, as a gift: dkozin-Reflist(3).rtf.pdf
  19. Yes, Jay is doing pretty damn well considering. So, if managing the board, paying for it and regular life successfully is a measure of success handling the disorder than I think Jay is doing quite fine. However, visuals are probably just as they were a few years back. - dk
  20. This is a good list. I am setting up the space where people with HPPD, their allies or medical professionals can use to look up information about the big questions: What pharmacological treatments have evidenced based positive results? What medications are specifically CONTRAINDICATED for individuals with HPPD? The page would have 30 or so medications I would imagine. It could be broken down into a Professional and a Consumer Page. I think it would be nice if a more advanced write up with citations were included as a Continuing Medication Education "type" certification, which a licensed medical professional can take in order to be listed on the World Map with their information as a doctor that at minimum has familiarity with the most important concepts.| The goal of the web site is to create the most value and impact with the little money that we have. If individuals with HPPD go to one of these doctors, and the doctor does not prescribe risperidone as a first line of defense because the web site details a very outspoken research and patient community about why this class of anti-psychotics will produce an increase in symptoms. Imagine saving 5 people from having to experience this awful period, which I have known some people to have been hospitalized and placed on anti-psychotics, and as the symptoms got worse they prescribed more antipsychotics. It was about 6 months or maybe a year later, the medication was stopped and the symptoms were dramatically improved. This is where everyone can have an impact.
  21. http___hppdonline.com_ Performance 2019-08-03 - Sheet1.pdfhttp___hppdonline.com_ Performance 2019-08-03 - Sheet1.pdf
  22. I will get into this in a person message, but to be short: They are using it on an Amazon server if I had to guess. The issues are: 1) I created a message board system in 1998, then I used early versions of PHPBB and eventually SMF. I have hosted the web site since 1998, and the most traffic the site received was between 2001-2004? I eventually ended up with a managed dedicated server. Honestly, this was a waste of money. 2) HPPDonline.com has cost $30 for over 20 years. Hosting cost about $200/month for about a two year period while hosting the research for Depersonalization disorder and heavy traffic. 3) Hosting has cost $7,000 over that period. 4) I have two goals for research that must be maintained for the web site (If I want to use it as such), but either way I refuse to have anyone other than myself or Jay have access to the actual database. As it is, we have have moderation action logged, every wrong login from an Admin marked and because 9 our of 10 members do not sign in, and I know a lot of them because risking even having any meta data connected to HPPDonline.com and your workplace, spouse, partner, etc (in many more cases that the younger generation might actually appreciate) would mean people would get fired, divorced and just for finding a job for those of us with public front "ends": I am unable to find any normal work. Every hiring agency runs a Google search at minimum. The Harvard and publication work only works FOR me if I am applying for a position that requires me to be a researcher. Other that this, would you hire someone you didn't know to process you data entry if over 20,000 pages on Google link to this new employees name to drug use, tripping and why are they applying here? 5) SO, I AM VERY PROTECTIVE ABOUT THE DATABASE. It is also information that gets included in a write up for a grant. Writing, "Limesurvey is hosted on Little Jimmy's Server Appliance in his bedroom next to his EZ Bake Oven and the family's alcohol" just won't make it as good as 24/7 Linux Engineers, with multiple datahousing centers and data storage compliance is XXXXXX, including Carbon Offsetting XXXXX". 6) So, I am going to ask the people who run the hosting for Joomla's own sites if they have experience pulling from Invision Power Web databases and importing it, and put on one of their plans that do not use hyperbole and I can e-mail the tech's at the firewall if I want to create my own rules/etc. The owner of 15+ years still works with others on the floor. The host is https://www.rochen.com/ Any discussion I am open to hear, but need blood and sweat to be convinced otherwise. Rochen has edited PHP and other scripts as part of normal support while I was caught in a jam. The support is amazing. We could all pay for it with a cryptocurrency donation. BAT coin? Using Brave server. Anyway,. I would also need some people for developing static web pages. If you want a history of HPPDonline.com... check out the Internet Archives. HPPDONLINE.COM OVER THE AGES: |
  23. It was a spike for 1 month. and dropped already back to normal. I have a few ideas, but one part is I hate that I lost the ability to access the raw database files without having to ask for them. Maybe a paradigm shift for the whole community? But, after we have the information in our hands only, store off cloud (i took like it on an Amazon server. There are people expressing interest in writing static content, but I just don't want to loose the research and info aspect. We do have hppdonline.com and can point it wherever, but should wait until we take the stuff with us. I have to pick up family from train station today, cleaning house and I am moving back from a temporary living situation while handling the medication withdrawal, and now that I have jumped down I will have a new phase. - dk
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