so lately with NSI-189 and all I've been looking in to neurogenic substances. Maybe some of you have heard of this small molecule. 7,8 dihydroxyflavone (7,8-DHF), is a potent agonist at the TrkB receptor. More about the TrkB receptor here.
Here's one study in particular I find interesting:
A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect
7,8-Dihydroxyflavone and its Derivatives Useful for Treatment of Neurodegenerative Diseases
Drug Reduces the Increase in Fear Caused by Previous Traumatic Experiences in Mice
Effect of 7,8 - Dihydroxyflavone, a Small - Molecule TrkB Agonist, on Emotional Learning (a neat PDF, which also mentions that 7,8-DHF protects against kainic acid induced neuronal apoptosis).
Questionably legitimate experience:
Group buy: http://www.longecity.org/forum/topic/67693-official-78-dihydroxyflavone-group-buy/ "yadayada" is working on acquiring some too. I went ahead and ordered 1 gram of the stuff from the last link. Some things to consider:
No in vivo human studies have been conducted
TrkB agonism may cause eventual downregulation
There are some concerns of BDNF overexpression being detrimental to one's neurological health
Human equivalent dose has been calculated to be around 30mg, so a gram should be enough for a month.
May be synergistic with NSI-189 and Cerebrolysin.
If you've any questions; shoot. Cheers.