Merkan Posted March 6, 2016 Report Share Posted March 6, 2016 Waiting for the b1 now from iherb. Same stuff but without the extra B-vitamines. Will probably arrive next week Link to comment Share on other sites More sharing options...
VisualDude Posted March 7, 2016 Author Report Share Posted March 7, 2016 One curious factor about thiamine cocarboxylase since it is a vitamin instead of a medication, is the dosing. With meds (Klonopin, Keppra, Sinemet, etc), one can take too much or too little. But with thiamine you just take some to replete and wait for any effects. Once you get past a few mgs/day, it won't matter. The more deficient/depleted, the more rapidly one would notice effects. Its been 7 weeks now for me and don't notice anything when taking or skipping a dose ... but notice that overall feel substantially better, though not 'cured'. Merkan, You could try some 'regular' thiamine and see if you benefit (typically thiamine mononitrate is what is added to food and in supplements). I tried this the 2nd day (100mg mononitrate) and felt nothing, yet took 3mg cocarboxylase a couple hours later and felt it in within the hour. This is suggestive of a metabolic conversion problem as opposed to an absorption or malnutrition issue. At some point you will not notice whether you take it, but will see overall changes in the weeks to come. It will be interesting to see how (or if) you change your medication levels. Do you notice any difference since the first day? You've only been taking it 6 days so far. Are you retaining benefits? Are you gaining additional benefits? Link to comment Share on other sites More sharing options...
Merkan Posted March 7, 2016 Report Share Posted March 7, 2016 I felt a big difference the first three days. Already feels like its leveling out. The Idea of trying to lower the Keppra came out of the blue the other day, obviously an effect from not being scared of a transient flare-up. One curious factor about thiamine cocarboxylase since it is a vitamin instead of a medication, is the dosing. With meds (Klonopin, Keppra, Sinemet, etc), one can take too much or too little. But with thiamine you just take some to replete and wait for any effects. Once you get past a few mgs/day, it won't matter. The more deficient/depleted, the more rapidly one would notice effects. Its been 7 weeks now for me and don't notice anything when taking or skipping a dose ... but notice that overall feel substantially better, though not 'cured'. Merkan, You could try some 'regular' thiamine and see if you benefit (typically thiamine mononitrate is what is added to food and in supplements). I tried this the 2nd day (100mg mononitrate) and felt nothing, yet took 3mg cocarboxylase a couple hours later and felt it in within the hour. This is suggestive of a metabolic conversion problem as opposed to an absorption or malnutrition issue. At some point you will not notice whether you take it, but will see overall changes in the weeks to come. It will be interesting to see how (or if) you change your medication levels. Do you notice any difference since the first day? You've only been taking it 6 days so far. Are you retaining benefits? Are you gaining additional benefits? Link to comment Share on other sites More sharing options...
ddiddy66 Posted March 10, 2016 Report Share Posted March 10, 2016 Been taking 3 in the morning and sometimes 2 in the afternoon. I've definitely benefited. My energy level has been up though I still crash later in the day sometimes. It's been 3 weeks now. No other symtoms have been helped but any help for my fatigue is priceless. Link to comment Share on other sites More sharing options...
ddiddy66 Posted March 10, 2016 Report Share Posted March 10, 2016 Thank you Visual for introducing this. 1 Link to comment Share on other sites More sharing options...
hppd33 Posted March 10, 2016 Report Share Posted March 10, 2016 the brainfog and memory,concentration are terible for me i feel i am like a old man write a small text here cost me 2 times more time, i have just spend a lot of money for supps never found something that i realy can say if it works I am using gingko biloba and omega 3 for few weeks again and i read a doctor book and he saw improvment in his patients with gingko this was a good sign to continue buth he says they geth improvment in short and longterm I dont know i can say postieve about that When i quit klono cold turkey a month later the issues geth lot worser i am still not geth better seems i have some permanent damage, its now 1 year later I have recently did a bloodcheck nothing realy to find for sign about it The last thing to do is quit tobacco and see if i geth better buth it isnt easy I wil try TC and post soon here the results finding something thats work individual is realy a roulette finding the right dose and quality to Getting tired to make the same faults and forgetting so much cost me so much time and money,frustration in social life because i cant focus I may just move on to out of a city I never been succes full here have you tried sinemet? Link to comment Share on other sites More sharing options...
VisualDude Posted March 10, 2016 Author Report Share Posted March 10, 2016 Yes it helps me the brainfog, i only take 1 pill a day. Have you tried 2 or 3 per day? Also, did sinemet help you? (Perhaps the combination would help???) Been taking 3 in the morning and sometimes 2 in the afternoon. I've definitely benefited. My energy level has been up though I still crash later in the day sometimes. It's been 3 weeks now. No other symtoms have been helped but any help for my fatigue is priceless. It is truly amazing that someone suffering HPPD for 25 years would get any benefit from a simple vitamin. Fatigue is one of the most debilitating things with HPPD. While anxiety is perhaps the most 'painful' and most discussed, often when it is resolved there still remains some level of fatigue. TC definitely has improved my energy (easily gained an hour or two per day) ... but the later half of the day still tends to wipe out. Its been just over 7 weeks now and still a subtle leveling off. [ There is a young man where I live who has been trying TC for 2 weeks so far (he suffers very bad fatigue, not HPPD). He doesn't perceive any change but his parents say he is doing a lot more. So it isn't conclusive but if it is helping, it is illustrative how subtle/slow improvement is and how entrenched fatigue often is. ] So you don't see changes in visuals. Do you have visual snow and/or DR? What are your main visual symptoms? wish i read this before finally buying a B complex yesturday. lol...wrong form of thiamine Are you getting help with 'regular' thiamine? (this B complex you started with) Or did you later get thiamine cocarboxylase and it helped you? (And if so, which product?) [ I realize that these are a lot of questions but it is important to clarify to help each individual and assess what might be good for others - to understand the underlying mechanisms of each HPPD symptom. ] Link to comment Share on other sites More sharing options...
hppd33 Posted March 10, 2016 Report Share Posted March 10, 2016 Sinemet helps me perfectly. It was a question for umit Link to comment Share on other sites More sharing options...
ddiddy66 Posted March 10, 2016 Report Share Posted March 10, 2016 i have visual snow, DR, the ground and patterns move. i still don't know all the terms for my systoms. i didn't get any noticeable benefit from the regular B complex. Link to comment Share on other sites More sharing options...
hppd33 Posted March 10, 2016 Report Share Posted March 10, 2016 Try sinemet everything is stationary if it works for you Link to comment Share on other sites More sharing options...
ddiddy66 Posted March 10, 2016 Report Share Posted March 10, 2016 i got some Sinemet from a friend with Parkinsons. i cant seem to give it fair try because it actually increased my fatigue and makes me so irritable. when i get a good baseline with Keppra (been taking for six weeks) and TC (been taking for three weeks) gonna give it another go Link to comment Share on other sites More sharing options...
ddiddy66 Posted March 10, 2016 Report Share Posted March 10, 2016 to me, thats the most interesting thing about TC. my brain seems to shut down with any stimulant (caffine, Sinemet). i will litterally be jittery from caffine but my brain wants to go to sleep. not sure if over the years my brain naturally does this to prevent anxiety or if the Effexor I take causes this to block anxiety. its what i consider brain fog. Link to comment Share on other sites More sharing options...
hppd33 Posted March 10, 2016 Report Share Posted March 10, 2016 I can drink cafeïne I can drink a few beers. Nothing makes it really worse. Maybe its because I take benzos Why I can drink cafeïne, coffee is the only thing I really enjoy. When im not on benzos im not sure if I can drink coffee anyway I dont remember a life without benzos. Also im not sure if taking benzos can heal hppd or not. Time will tell. Link to comment Share on other sites More sharing options...
ddiddy66 Posted March 10, 2016 Report Share Posted March 10, 2016 do you have issues with fatigue and brain fog? Link to comment Share on other sites More sharing options...
ddiddy66 Posted March 10, 2016 Report Share Posted March 10, 2016 im taking Bio-3B-G from Biotics Research Link to comment Share on other sites More sharing options...
Guyindubai Posted March 10, 2016 Report Share Posted March 10, 2016 i got some Sinemet from a friend with Parkinsons. i cant seem to give it fair try because it actually increased my fatigue and makes me so irritable. when i get a good baseline with Keppra (been taking for six weeks) and TC (been taking for three weeks) gonna give it another go how much of the Keppra are you taking ? Link to comment Share on other sites More sharing options...
ddiddy66 Posted March 11, 2016 Report Share Posted March 11, 2016 500mg am/ 500mg pm Link to comment Share on other sites More sharing options...
Guyindubai Posted March 11, 2016 Report Share Posted March 11, 2016 500mg am/ 500mg pm Noticed any improvement in sympots ? If so what improvedV Link to comment Share on other sites More sharing options...
ddiddy66 Posted March 11, 2016 Report Share Posted March 11, 2016 ill update and discuss on my Levetiracetam thread Link to comment Share on other sites More sharing options...
Kellen Posted March 11, 2016 Report Share Posted March 11, 2016 got a buddy to order some for me off amazon. they sent the bio GGG instead of the bio 3b g https://www.bioticscan.com/1143 he sent it back and placed another order with a different supplier and they sent the same thing!! this time he cant return it unreal ive waited so long really want to give this a try but now im out 50$ and things are tight already. is the GGG okay to take? it has a much smaller dose of TC and is made up of different stuff than the 3b g. man this is so frustrating Link to comment Share on other sites More sharing options...
VisualDude Posted March 11, 2016 Author Report Share Posted March 11, 2016 is the GGG okay to take? it has a much smaller dose of TC and is made up of different stuff than the 3b g. That should be fine ... who knows, a little lamb brain won't hurt. I've also tried the Immunozyme Forte and it works good ... some bovine placenta and parotid too, lol. The 3B-G is the cheapest but returns and shipping isn't worth the bother. Its great you were able to get something with TC. All of these have thiamine cocarboxylase: 1 pill = 1.0 mg with Bio-GGG-B http://www.bioticsresearch.com/sites/default/files/productlabels/1143-web.pdf 1 pill = 1.5 mg with Bio-3B-G http://www.bioticsresearch.com/sites/default/files/productlabels/1137-web.pdf 1 pill = 0.5 mg with Bio-B-100 http://www.bioticsresearch.com/sites/default/files/productlabels/1133-web_0.pdf 1 pill = 5.0 mg with Bio-Immunozyme Forte http://www.bioticsresearch.com/sites/default/files/productlabels/6300-web.pdf Guess start with 2 or 3 and see how it goes. Hopefully you respond well! ... then you can work out better prices. What meds are you on right now? What are your most annoying symptoms? Link to comment Share on other sites More sharing options...
VisualDude Posted March 11, 2016 Author Report Share Posted March 11, 2016 While 'specializing' (focused primarily) on dopamine, one would be remiss to ignore other neurotransmitters. Already mentioned is thiamine's importance for acetylcholine and GABA. Now the topic of serotonin must be explored because of its involvement with both HPPD and thiamine metabolism So started a thread, Serotonin and HPPD http://hppdonline.com/index.php?/topic/5120-serotonin-and-hppd/ Read the first post there and then compare with TD Serotonin and Thiamine Deficiency Thiamine deficiency alters serotonin function: “Thiamine deficiency: selective impairment of the cerebellar serotonergic system” http://www.ncbi.nlm.nih.gov/pubmed/27736 “It is known that several neurons, especially marked in serotonergic neuron, are damaged in humans and rodents in the earlier phase of TD” http://www.ncbi.nlm.nih.gov/pubmed/15164618 “These results suggest that acute thiamine deficiency, induced by PT, both increases brain 5-HT synthesis and impairs 5-HIAA efflux from the brain” http://www.ncbi.nlm.nih.gov/pubmed/509224 “There is a close correlation between neurological manifestations and changes in brain 5-HT metabolism in acute thiamine deficiency” http://www.ncbi.nlm.nih.gov/pubmed/509224 “changes in the density of the postsynaptic 5-HT2A receptor population” http://www.ncbi.nlm.nih.gov/pubmed/8752118 Reading these texts show that serotonergic alterations occur in mild as well as severe TD. With these points in mind, it is no great leap of imagination to speculate that developing HPPD may involve low thiamine levels or metabolism. Or that the progression of symptoms can be interrelated. Or that recovery could be hampered by such. Link to comment Share on other sites More sharing options...
Kellen Posted March 11, 2016 Report Share Posted March 11, 2016 Currently on 25 mg lamictal still and its hell. Worst symptoms Dp/dr Major Cognitive dysfunction. Can't think or speak properly Severely Fatigued Crazy visuals Tons more but those are the worst right now Link to comment Share on other sites More sharing options...
Tinbird Posted March 12, 2016 Report Share Posted March 12, 2016 Hey guys, sorry my english is not so good so I have to ask this question. Do I have only to take Vitamin B1 for a possible improvement? Or do I need a Vitamin B Komplex? Maybe can anyone suggest for me a good and cheap supplement that I can buy in europe, especially in germany. Edit: Ah okay I need "Thiamine". I found a Vitamine B Komplex what contains 35mg Thiamine per capsule. How much mg I need per day? Link to comment Share on other sites More sharing options...
VisualDude Posted March 12, 2016 Author Report Share Posted March 12, 2016 Hey guys, sorry my english is not so good so I have to ask this question. Do I have only to take Vitamin B1 for a possible improvement? Or do I need a Vitamin B Komplex? Maybe can anyone suggest for me a good and cheap supplement that I can buy in europe, especially in germany. Edit: Ah okay I need "Thiamine". I found a Vitamine B Komplex what contains 35mg Thiamine per capsule. How much mg I need per day? Normally 35mg thiamine would be plenty, so if you have that already, then try it. However there is a problem for some of us that 'regular' thiamine doesn't do anything useful. Most thiamine is listed as thiamine, or thiamine mononitrate or thiamine hcl. What we are testing on this thread is specifically thiamine cocarboxylase. It is readily used by the body ... so that is the form you will want to try. It doesn't seem to require much (I take in the range of 3 to 10 mg / day) Link to comment Share on other sites More sharing options...
Recommended Posts
Create an account or sign in to comment
You need to be a member in order to leave a comment
Create an account
Sign up for a new account in our community. It's easy!
Register a new accountSign in
Already have an account? Sign in here.
Sign In Now