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History of HPPD: Section 2 of 5. Available in PDF


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#1 David S. Kozin

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Posted 21 June 2011 - 11:47 AM

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#2 David S. Kozin

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Posted 21 June 2011 - 11:52 AM

I like this little piece because it shows a history of our disorder from 1955 that remained constant and if you read the old articles the descriptions match what is know today. The question is: How was this ignored for so long? In 1969 we knew almost all of the characterization of HPPD.

- David

#3 Br0k3nS41nt

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Posted 21 June 2011 - 01:23 PM

his is a real interesting read, although the pdf is just showing up as jibberish symbols for me.

I find it interesting that non HPPD lsd users do perceive changes, I find it strange how these changes don't bother them.

I also like the suggested cause of the disorder put forth, a tendency for receptor density to not return to normal makes so much sense to me, if I understood everything correctly.

#4 Br0k3nS41nt

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Posted 21 June 2011 - 01:41 PM

Also the qEEG results are something definetly of note.

#5 David S. Kozin

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Posted 21 June 2011 - 02:36 PM

Attached File  History_HPPD.pdf   462.23KB   20 downloads

updated PDF.

This is a very tiny section. Just felt historical today.

- David

#6 David S. Kozin

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Posted 21 June 2011 - 02:43 PM

Uploaded Horowitz article for users. Do not distribute besides personal use. I think it is eye opening to see what was being said so long ago.

Link in original post.

#7 shaolinbomber

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Posted 21 June 2011 - 02:48 PM

Changes in receptor density was the conclusion I came to a year and a half to two years ago when I was doing nothing but reading reading and reading more about the subject non-stop. It seems as if the generation of receptor proteins during or after a significant drug session to cause enough change in the visual cortex to be semi-permanent to permanent makes the most sense out of anything else. The other idea I dwelled on was cell death, but that doesn't make much sense to me. If a consumed drug was powerful enough to cause apoptosis then I don't believe it would be confined to one specific area of the brain.

#8 Br0k3nS41nt

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Posted 22 June 2011 - 04:02 AM

Plus if a large amount of cells die--like would be the case with hppd--either through apoptosis or necrosis, it would make sense that there would be inflamation or leasons, which are detectable by a mri.

While changes in receptor density is totally undectable on a standard mri.

#9 WindScar

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Posted 22 June 2011 - 04:11 AM

This is another thing I never understood. I have read that neurotransmitter depletion is something that is slowly fixed as certain amines reach our brains. But what about their receptors? When a receptor is damaged, how is it fixed? Is our brain continuously making new receptors?

I have seen an animation showing how a strange molecule that is similar to a neurotransmitter will bind to a receptor as if it were the neurotransmitter, but leaving a kind of damage because of it's different structure. If that is true I wonder why nobody talks about this effect when the subject is HPPD, because looking at the structure of LSD, it is really similar to serotonin.




In time, if the problem is actually a change in receptors density, aren't there lots of methods available to up regulate a group of receptors?

#10 David S. Kozin

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Posted 22 June 2011 - 05:02 AM

1) Cellular death would be detectable only if the neuronal damage large enough scale. However, this is unlikely because 1) not dose dependent to severity correlational, let alone causal relationship, 2) delayed onset post-precipitant event when assumed to be hallucinogen related.

2) Regarding the depletion of neurotransmitters: I cover this in my Neurobiology section, but here is the very short version: Depletion can occur via multiple mechanisms. Including agonism at the receptor resulting in depolarization of the cell and release of transmitters in the cell and receptor density lowering immediately. Receptors are replaced and damage to a receptor would persist only if the genes encoding for the receptor were altered, a specific sub-unit of a receptor is improperly coded, or the early immediate-early gene like c-fos. If HPPD individuals were particularly sensitive to returning to normal gene expression after experiencing changes then you have one possible explanation. The neuron is not making receptors at the same rate because of long-term potentiation for example. In the case of benzo use, the GABA receptor will down-regulate. It takes a long time for the cells to process and eventually return to the normal rate to generate the receptor complexes.

3) LSD is great at binding to specific 5-HT receptors. If LSD were to cause a conformational (structural) change in a receptor, it would happen to all users of LSD. Unless, the HPPD individual has a receptor complex that is just enough "off" in structure to be suceptible to this alteration in structure (for example, some chemicals will actually get stuck and block the receptor, I think picrotoxin operates this way. However, the affect would be dose dependent and we would look for problems with other serotonin agonists (including serotonin itself). LSD also is rare in that it has Dopaminergic action as well.

I'll try to get this out as soon as possible. Do know that 5-HT receptor density in blood platelets is one way to measure what is happening in the brain.

#11 WindScar

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Posted 25 June 2011 - 09:11 PM

Great post David, thank you. Where's the neurobiology section?