dasitmane

Bit of an idea for possible CURE. Has some weight to it.

613 posts in this topic

I also wanted to add that its very unlikely that the purkinje fibers in the heart would be affected in this condition. As for the nodes and such of the heart I hardly doubt as well, Im not ruling that out completely yet though. But I hope to God that the neurons in the heart are not affected in this case, as it would be quite detrimental if they by any chance send anxiety/fight/flight responses to the brain triggering it, then the anxiety would most likely be incurable, where as if all the damage is located specifically to the central nervous system it should be fine and curable up to I would guess anywhere from 80% to 99% improvement, which realistically is remarkable, and would make life bearable for this horrific disease. 

So anyways to wrap all this up its extremely clear at this point as to the cause of this disease, and how it develops, etc. 

Edited by dasitmane
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New study shows 70% proliferation of neural progenitor cells. Which basically means neuronal stem cells that are limited to the amount they can replicate. The study did not however show if there was any replacement of lost neurons. Also, anyone reading this, please realize that harmine is hallucinogenic and proven in one of the studies posted already in this thread to kill neurons, so please to not take harmine on a random chance that it might improve your hppd, as of right now it would most likely just make it worse. 

https://www.sciencedaily.com/releases/2016/12/161207124115.htm

Human neural progenitors exposed to harmine, an alkaloid presented at the psychotropic plant decoction ayahuasca, led to a 70 percent increase in proliferation of these cells. The effect of generating new human neural cells involves the inhibition of DYRK1A, a gene that is over activated in patients with Down syndrome and Alzheimer's Disease. Thus harmine could have a potential neurogenesis role and possibly a therapeutic one over cognitive deficits.

 

 

Ayahuasca is a beverage that has been used for centuries by Native South-Americans. Studies suggest that it exhibits anxiolytic and antidepressant effects in humans. One of the main substances present in the beverage is harmine, a beta-carboline which potential therapeutic effects for depression has been recently described in mice.

 

"It has been shown in rodents that antidepressant medication acts by inducing neurogenesis. So we decided to test if harmine, an alkaloid with the highest concentration in the psychotropic plant decoction ayahuasca, would trigger neurogenesis in human neural cells," said Vanja Dakic, PhD student and one of the authors in the study.

In order to elucidate these effects, researchers from the D'Or Institute for Research and Education (IDOR) and the Institute of Biomedical Sciences at the Federal University of Rio de Janeiro (ICB-UFRJ) exposed human neural progenitors to this beta-carboline. After four days, harmine led to a 70% increase in proliferation of human neural progenitor cells.

Researchers were also able to identify how the human neural cells respond to harmine. The described effect involves the inhibition of DYRK1A, which is located on chromosome 21 and is over activated in patients with Down syndrome and Alzheimer's Disease.

"Our results demonstrate that harmine is able to generate new human neural cells, similarly to the effects of classical antidepressant drugs, which frequently are followed by diverse side effects. Moreover, the observation that harmine inhibits DYRK1A in neural cells allows us to speculate about future studies to test its potential therapeutic role over cognitive deficits observed in Down syndrome and neurodegenerative diseases," suggests Stevens Rehen, researcher from IDOR and ICB-UFRJ.

 
Edited by dasitmane
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181663/

Just going to leave this here for future reading. 

I am finding a lot of information saying that hallucinogens do not cause neuronal loss, but I'm still doubtful. 

Found in the article posted

Recent electrophysiological studies have produced new evidence that both psychedelic hallucinogens and NMDA antagonists activate the serotonergic system and enhance glutamatergic transmission via non-NMDA receptors in the frontal cortex.93,94 Whether this common mechanism contributes to the higher-level cognitive, perceptual, and affective effects of serotonergic hallucinogen and NMDA antagonists warrants further investigation.40

So excitotoxicity via glutamate could be the culprit. 

Enjoy some music guys. Fast forward to 1:19:30

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Edited by dasitmane
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Hey, 

 

 I have been feeling really down. 

I have, sort of, accepted I will always have this tremendous panic, anxiety, and depression.   And I find in my daily life these things are often reinforced by certain things. 

I don't have any advice to give.  

I am sort of watching my life go by.   

It is not the worst thing in the world, I suppose.

But a series of difficult incidences have left me very affected. 

 

It's the same sort of emotive/limbic reaction I have had in the past. Except I am older.  I deal with it a bit differently. 

Mortality seems so real now.  

 

I will probably never be able to function 'normally' in society ever.

 

Oddly, I see my life playing out to my death.   It might be a while or not.  I don't know. 

What I do know is that I feel like I have been forced not to care.   No one person in particular is forcing me not to care; I think time is forcing me not to care.  

 

In my life, that is the only thing I really am ashamed of is being forced not to care.   Because I am a compassionate person.  But none of it matters because I think compassion is too much of an abstract idea for people.  

 

I have made loads of mistakes.   But the core of me is good. 

 

I wish you all great love!  

[This makes me think of this Richard Alpert speech where he says Suffering is caused by the want for permanence.  Well, I am definitely paraphrasing, I am not sure exactly what he said, but I think my feelings are going beyond that, in not a great way, at this moment.   This is a bad place I am in, permanence or not.]

 

 

Edited by mgrade
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Prior to New York Times Magazine, May 7th 2017 edition, without any knowledge, this is what I posted on social media:  

 

 

Screen Shot 2017-05-09 at 1.19.54 AM.png

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Canada and Australia, the UK, under the devices of the United Kingdom, have taken on Mexico, Latin America, South America, the Caribbean, etc. as a means to the               'Global Laudromat'.    

 

Drugs, Smuggling, Human Trafficking, Money Laundering, etc. 

 

[Note: likely involved in Russian money laundering as well].  

Scotiabank, HSBC, etc.

 

Edited by mgrade
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Has anyone by chance found any information as to what may be the most definitive cause for this condition.

 

The only 3 specific things that I can think are

Neuronal excitotoxic apoptosis

Chemical embedment in the synapses that cant be broken down

Or some altercation of DNA changing neuronal function

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Frying your brain with dissociative or hallucinogenic compounds ...

 

Consciousness is a complex thing.  You start bungling with the circuitry of the brain, your collective sensory system and cognition get all messed up.  

 

I'd say if you get this from a dissociative drug, it tends to be more NMDA/G related.  LSD: serotonin.  Amphetamine/MDMA: Dopamine 

 

 

 

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