Samm Posted July 24, 2012 Report Share Posted July 24, 2012 I have a huge problem, my neurologist won't subscribe me keppra. I explained her about HPPD but I'm not good of a talker.. I used to be very social but now i suffer from HPPD I'm not that smooth anymore. She said she could only help me with issues in the form of neurology, like migraine. She also said I probably have to go to a psychiatrist with my hppd What do I have to do to get keppra from a neurologist / doctor / psychiatrist? Please, I need advice! 1 Link to comment Share on other sites More sharing options...
gill Posted July 24, 2012 Report Share Posted July 24, 2012 I guess I got lucky because my regular doctor let me try it. I did present him with the following abstract: " Levetiracetam efficacy in Hallucinogen Persisting Perception Disorders: a prospective study. Casa, B, Bosio, A. Drug Monitoring Service, New York NY; USA; Mater Dei Clinic, Rome, Italy. Journal of the Neurological Sciences, Volume 238, Supplement 1, 2005, p. S504. Abstracts of the XVIIIth World Congress of Neurology "Background: The occurrence of flashbacks following use of drugs is a recognised condition known as Hallucinogen Persisting Perception Disorders (HPPD), therapy for wlffch is based on neuroleptic and attticonvulsant medication. Tiffs prospective study assessed the efficacy of the novel antiepileptic drug levetiracetam (LEV) in treating patients with HPPD over a 1-year period. Method: Patients with HPPD were treated with LEV 1500 mg/day (500 mg in the morning, 1000 mg in the evening) for 1 year. Daily flashback frequency and electroencephalogram (EEG) assessments were conducted at Day 0, 15, 30, 60, 90, 180 and 360. The incidence of adverse events was monitored throughout the study. Results: 27 patients (121 males, 6 females), with a mean age of 21.8 (range 18-26) years, were enrolled. At baseline, mean daily flashback frequency was 9.3 (range 1-45) and EEG assessment demonstrated temporal slow patterns in all patients. Over the 1-year treatment period, 20/27 (74.1% ) patients became flashback-free. After 15 days, 7/27 (25.9% ) patients were already without clinical manifestations, with 6 patients demonstrating > 75% reduction in flashback frequency and 1 demonstrating 50-75% reduction. EEG patterns normalised in 18/27 (66.7% ) patients after 30 days and in 23/27 (85.2% ) after 90 days. 3/27 (11.1% ) patients continued to have flashbacks, despite complete disappearance of EEG abnormalities. Side effects were few in incidence and mild in severity. No patient discontinued treatment. Conclusions: This study demonstrated LEV to be highly efficacious in the treatment of HPPD, with very good tolerability and ease of use." Link to comment Share on other sites More sharing options...
ludwig80 Posted July 25, 2012 Report Share Posted July 25, 2012 Wow, how have not seen this abstract.. The clinical success rate is pretty fantastic - I guess the word "flashback" is what needs to be defined. Could mean a lot of things. Link to comment Share on other sites More sharing options...
ludwig80 Posted July 25, 2012 Report Share Posted July 25, 2012 Btw samm, My EEG came up as slIghtly abnormal and the first thing the doctor suggested based on my situation was Keppra. It has helped some things, some not. Link to comment Share on other sites More sharing options...
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