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Found 1 result

  1. Hello! I know that alot of people here going on benzos. Especielly clonozepam. Clonozepam worked wonders for me on a daily basis 2mg/day untill i devoloped tolerance after 6 months. And that's the main problem with benzos. Tolerance. But how do we solve tolerance then? Well, i've been looking at a GABAA-antagonist called Flumazenil. And there is some pretty intressing facts about flumazenil on Wikipedia. https://en.m.wikipedia.org/wiki/Flumazenil I will quote some of them: "Epileptic patients who have become tolerant to the anti-seizure effects of the benzodiazepine clonazepam became seizure-free for several days after treatment with 1.5 mg flumazenil. Similarly, patients who were dependent on high doses of benzodiazepines (median dosage 333 mg diazepam-equivalent) were able to be stabilised on a low dose of clonazepam after 7–8 days of treatment with flumazenil." "Laboratory research studies using tissue cultured cell lines have shown enhancement of the benzodiazepine binding site after chronic treatment with flumazenil where sites have become more numerous and uncoupling/down-regulation of GABAA has been reversed. After long-term exposure to benzodiazepines, GABAA receptors become down-regulated and uncoupled. Growth of new receptors and recoupling after prolonged flumazenil exposure has also been observed. It is thought this may be due to increased synthesis of receptor proteins." "In Italy, the gold standard for treatment of high-dose benzodiazepine dependency is 8–10 days of low dose, slow infusion of flumazenil.[12] One addiction treatment centre in Italy has used flumazenil to treat over 300 patients who were dependent on high doses of benzodiazepines (up to 70 times higher than conventionally prescribed) with doctors being one of their most common patients." So basicly what Flumazenil does is to reverse the tolerance. Also growth of new receptors have been observed which i find verry intressing. I know this haven't been discussed on this forum before so my generaly question is really, have anybody tried Flumazenil? And if not, do you think this could be a way to use benzo for a long term treatment of HPPD?