K.B.Fante

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  1. Interesting connection to choline. I just posted in another thread about anticholinergic syndrome and it's relation to HPPD.
  2. Man, that sounds rough. I guess we're all in the same boat, but society has always told us weed is safe and it's so painfully clear that's a complete lie. Lots of people with DP-DR report the same sort of story you do. DP-DR often comes with a variety of visual disturbances and some overlap with HPPD. Can you pinpoint exactly which symptoms you have and which are getting worse? That might be a good place to start. Also, you should examine how healthy your diet and lifestyle are and if they're less than superb you should try and help yourself in those respects. I've posted lots of dieting advice recently in case you're interested.
  3. OK, bit of an update: It's been three days now and symptoms have definitely subsided. They're still lingering but it's nothing too bad. I imagine at this rate I'll be clear of exacerbated symptoms in a few more days. As I mentioned above nutmeg contains myristicin which can be found in many foods including many nightshades which I've already touched on in a post here: http://hppdonline.com/index.php?/topic/5431-nightshades/#comment-34336 At this point I don't think there's even a question -- if you have HPPD you need to stay away from nightshades! These foods clearly contain multiple chemical agents that exacerbate HPPD. If you're someone who eats potatoes, tomatoes, peppers and others spicy foods on a regular basis then these are likely only making your condition worse. Additionally, myristicin can be found in many over-the-counter drugs, including antidepressants and antipsychotics. Here is a full list: http://emedicine.medscape.com/article/812644-clinical#b5 One of the above mentioned medications is an antihistamine called diphenhydramine. Last year when I couldn't sleep I took a few pills of this substance and noticed an immediate worsening of my symptoms the next day. I made a post about that which you can find here: http://hppdonline.com/index.php?/topic/5091-diphenhydramine/#comment-31926 In fact, if you search this site's database for "diphenhydramine" you'll come up with over 90 results and posts similar to mine wherein people get HPPD from this same drug. Here are a few: http://hppdonline.com/index.php?/topic/5228-acetycholine-and-hppd/#comment-33200 http://hppdonline.com/index.php?/topic/4581-diphenhydramine/#comment-28376 Myristicin is known to cause what's called anticholinergic toxicity syndrome. This is actually a somewhat common condition wherein people show up to the ER with a variety of symptoms including hypertension, urinary retention, tremors, dry mouth and skin, altered mental status, etc. However, the range of symptoms is quite large and also includes the following, which as some on this site have already noted, overlap with those of HPPD: pupil dilation, light sensitivity (photophobia), blurred vision, double vision, loss of accommodation and inability to focus on nearby objects (cycloplegia), tendency to be easily startled, memory problems, inability to concentrate, disorientation, brain fog, periodic flashes of light, visual snow, tunnel vision, warping or morphing, squiggly lines, patterns on surfaces, etc. Here is a full list: https://en.wikipedia.org/wiki/Anticholinergic One thing I've found interesting about neurotransmission when my symptoms have worsened is that it's often due to a lack of a transmitter. In caffeine GABA uptake prevented. In nutmeg and other myristicin it's acetylcholine. And if you go back to the original source, LSD, it's serotonin. In each case, as far as I can tell, there is a prevention of neurotransmission that causes HPPD symptoms to manifest. Would this not then suggest HPPD could be rooted in the brain's inability to absorb and or process certain neurotransmitters? I don't know much about this stuff so perhaps if someone else does they can chime in. Regardless, stay away from those nightshades!
  4. Best thing you can do is seek help, start going to support groups, radically clean up your diet to eliminate excess sugar, stimulants, fast food, etc., and of course try and get some exercise. Nothing ever stays the same and you will get through this, despite how difficult it seems, just as long as you get healthy and work your tail off to get better. I've been there before and I've done it, along with many others. But it's very hard and takes more effort and resiliency than you ever thought possible. Life is worth it in the end. This is just a temporary state.
  5. Here's a brief article on nutmeg that I found very interesting: https://naturespoisons.com/2014/03/20/myristicin-trippin-on-nutmeg/ Lots of overlap with HPPD. One of the quotes in there comes from a guy who basically had HPPD-like symptoms for up to two weeks after taking it, including DP-DR, depth perception issues and morphing. Also, the author speculates it's a 5-HT2A agonist, which again is the suspected culprit from LSD-induced HPPD. Whatever you do people, stay away from nutmeg!
  6. OK, so it's been two days since I ate the Nutmeg and the symptoms are still there. Last night I went to bed at 2 a.m. which I haven't done in over two years. I've sorta felt like I'm on caffeine, my heartbeat has been increased for two days straight and I have a general sense of mental instability and unease. I also have increased snow, trails, afterimages, a sense of detachment from my body and even CEVs which I haven't had since the first few days of my original HPPD. I also have dry mouth and some odd memories that are popping up at random, which sounds like standard symptoms for nutmeg. It's fair to say at this point I'm a bit worried just because I don't think I age that much nutmeg and the symptoms are still hanging around. They have decreased since the first day but not by that much. A quick Google search reveals the psychoactive substance in nutmeg is called myristicin which is the precursor for the synthesis of MDMA. As many of us know that's just about the worst drug you could possible do to get HPPD or exacerbate it. I'll keep trudging forward and hope for this to pass but considering it's been two days and its still very much there and very difficult to ignore I'm just getting concerned. In the past when I've overdose on caffeine the symptoms have decreased much faster and weren't quite as bad psychologically. This state I'm in now almost feels like, once again, a very light acid trip. I've been trying to heal from that state for two years now and was finally at the point where I was pretty good day to day. I've done so much to avoid drugs and anything that could worsen my symptoms, so the fact this happened after putting too much spice on my oatmeal is really discouraging to say the least. Just makes me feel like nothing is safe anymore. I'll keep everyone updated.
  7. http://gizmodo.com/scientists-used-crispr-to-reverse-huntingtons-disease-i-1796262804
  8. Yes, DP-DR are some of my worst symptoms. Getting better though. Also, add to the list nutmeg. It's a psychoactive substance that can even induce hallucinations if taking in large enough quantities. I've had a spice mix that I've been putting in my oatmeal in the morning and finally today put in way too much and felt essentially the same as when I ingest too much caffeine. Not a pleasant experience to say the least. Also, I find it interesting how I always react the same way to stimulants regardless of what they are. For example, I find myself staring in the mirror a lot more, paying way more attention to my symptoms and almost obsessing about them, being overly dramatic and negative, feeling as if the volume has been turned up inside my head and being unable to stop signing songs, etc. Just interesting how the pattern is always the same.
  9. As my symptoms have improved my pupils have decreased drastically. Obviously there's a correlation between HPPD severity and pupil size in my case, and certainly in some others. Your pupils function like the aperture of a camera: when they are open, more light gets let in and the picture is lighter; when they are closed less light gets in and the picture is darker. I'm of the belief that for whatever reason my pupils are letting in too much light and visual stimuli which is causing many HPPD symptoms. There is obviously some sort of sensitivity, but I think it comes back to my eyes allowing too much stimulus into my brain in the first place.
  10. I had crazy anger problems on Lamotrigine. I'd just wanna fight all the time and I've never been that type of person. Have you thought about trying other meds besides Keppra?
  11. Given all the psychological problems you're having it might not be a bad idea to try meds. It's your call though. If you feel unstable, like you might harm yourself or simply can't make it through the day then meds are usually a good idea at that point. They don't "cure" HPPD though so don't get your hopes up. Lots of people have a positive reaction to the ones you've mentioned but sometimes people don't react well at all either. The only way to heal is stay far away from drugs, go stone cold sober and live a healthy lifestyle.
  12. No worries! I knew where you were coming from. I never even thought of the hormones, which might have actually made my hormones messed up even more. All I know is I felt absolutely awful on dairy. As for being a vegan, it's actually pretty crazy how healthy you guys test out. Studies show time and time again that vegans are more healthy across the board than meat eaters. I don't know enough about the science as to why or whether we need meat, but from what I gather vegans tend to be healthier than just about any group around.
  13. I have thyroid issues and dairy is high in iodine so I just started to incorporate it into my diet to get iodine. Nobody really told me I had to. Bad choice obviously. I can't tell you how much better I've felt since getting off it again.
  14. For what it's worth, I contacted the authors of the recent North Carolina study about whether they think HPPD could be a result of a permanent sealing of the lid on the seratonin receptor and one of them said he thinks its highly unlikely. In fact, he specifically said he thinks there's no way it's even possible. Instead, he suggested the visual cortex could have become "sensitized" given our visual disturbances and the fact this area of the brain has a high number of 5-HT2A receptors. He sorta sounded like he was just spitballing, but I guess it's something. Still doesn't tell us much.
  15. I went dairy free for a year then went back on it for about the last four months due to other health issues. I felt like crap on it. I think cheese here or there is OK and doesn't seem to bother me, but milk, yogurt, etc., just made me feel terrible and gave me stomach aches. Not sure exactly why dairy is decreasing in popularity but I know it's high in glutamate which isn't good for our brains either.