David S. Kozin

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About David S. Kozin

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  1. Version 1.0.0

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    Current Topics in Behavioral Neurosciences
  2. Current Topics in Behavioral Neurosciences View File Current Topics in Behavioral Neurosciences Submitter David S. Kozin Submitted 06/24/2017 Category HPPD Research Articles  
  3. Here is the article that appeared as a book chapter. I am sharing it for the purpose of academic and general research for the benefit of the human condition. I do not want to give away the details that I will present, but I will be giving a critical analysis of it, which can have good and bad points. My video review will be part of the series of videos I will provide that will cost a nominal fee per viewing (for the first 6 months or so, and then it can be open to everyone.) However, it takes a lot of work to create, read, pay for the articles, student loans and put together the content so I have to stop feeling guilty for asking for money. This one is free, but as I discussed on the Facebook HPPD and DP/DR group, I will be returning to research and providing research reviews on my youtube channel, opportunities for individuals to learn research methods as a lay person or for work to design and receive funding for their own or co-designed research. If you have issues with the article, good, bad, in between you are encouraged to try and work through reading a research article and make notes either publicly or for yourself. I will go through it from a unique perspective. Even the general emotion it gives you. You get to be the judges. - David Kozin THE LINK IS BELOW: A copy will also be placed in the section for documents also. Current Topics in Behavioral Neurosciences pp 1-28 (2).pdf
  4. The potential for problems with the downregulations of serotonin receptors with LSD and epigenetics. I am going to need an aid to help with research compiling.
  5. I'm going to address this in a post, but I do want to say that I need you need to read for my answer (It will take me a little bit of time tonight to write, and I need to read a few things on the board afterwards before I release a video, but I am excited.
  6. As, GS stated above and to further add that visual processing goes through multiple stages. The retina is the only part of your brain that you can see. Also, the retinal cells work backwards and are constantly firing and stop firing when activated by a photon. Just adding my two cents that case studies are the lowest form of convincing research publications. They are helpful and can inform further ideas for controlled research.
  7. Fantastic to hear. People do have symptoms go away. Lowered anxiety can reduce symptom severity by reducing activity in the theorized GABAergic disinhibition system. Thanks for sharing.
  8. I had a serious leg injury and was on 10mg Oxycontin every 4-6 hours plus Morphine IV prn. I was fine. Honestly, I take Excedrine for headaches. Excedrine would stop headaches caused from MDMA abuse, Opiate induced headaches, Alcohol Hangover, Tension Headaches and Migraine. I know and worked with sufferers of Cluster Headache. One of the substances that is added to a compound thay works is Caffeine. Excedrine has Aspirin, Acetaminophen and Caffeine. It is more effective than Morphine for headaches for me.
  9. INTRODUCTION TO PHARMOKINETICS (With Specifics for the United States FDA rules and regulations) The half-life of Klonopin averages 40hrs. So, on day 4 you still have 50% of the dose you took 2 days prior in your system. 80% of the day prior. The value obtained with humans for available active clonazepam is a 3.3 fold increase from your daily dose. So, if you are taking 1mg/daily you achieve a steady state dose of 3.30mg. If you are taking 4mg/daily you reach 13.2mg. If you are taking .5mg a day, the steady dose = 1.65mg I created a calculator you can enter in a dose and it will calculate your body dose equivalency for 7 days. It is a google doc, I am pretty sure I locked the formulas, so only change the one value and press enter and it will change automatically for you. https://docs.google.com/spreadsheets/d/1EjTl8-ldbA_ZVaAgwrzjT613wKl3jAZxha2muLlkl8U/edit?usp=sharing Another very simple way to achieve the same thing is to take your daily dose and multiply by 3.3 or even more quickly by 3. This is a quick way to see why recommendations are for lower dose ranges. Dose Daily Effective Dose Potency at 7 Days 0.25 0.83 0.5 1.65 0.75 2.58 1 3.3 1.5 4.95 2 6.6 2.5 8.25 3 9.9 3.5 11.55 4 13.2 6 19.8 10 33 15 49.5 20 66 Typically, these are measured in nanograms per milliliter. This is only for clonazepam, and the half-life of a 2mg dose in a 2003 study was approximately 39 hour +/- 9 hours. Use of antacids can affect this number, liver function, kidney function and food. The average difference in C(max) and AUC between generic and innovator products was 4.35% and 3.56%, respectively. In addition, in nearly 98% of the bioequivalence studies conducted during this period, the generic product AUC differed from that of the innovator product by less than 10%. It also explains why having a day or so lapses in a Klonopin script are infinitely easier to handle than a Xanax script. Because the drop in concentration takes the same reduction, but Xanax half life is 11.2 hours. Klonopin Dose Calculations (Rough Estimations) I would discuss these with your doctor, and I also call them rough because other medications can potentiate the level or medications or supplements may occupy the enzyme in the liver that break down Klonopin, so it stays in the system longer. There are many variables, but this is a good general demonstration. .
  10. The question is not random at all. It is a great one. (I am going to speak to those without significant DP/DR, but the individuals that have lasting altered perceptual disturbances that at least in the early part of the disorder result in significant distress.) I started talking on the original forum in 1998. I was less than a year into the disorder, and happy that somehow found a name for it (Thanks to the old HPPD board by Andrew). So, I know there are many who have had HPPD for 40+ years like MadDoc above. I can say that the vast majority of them have adapted to the symptoms, and some of us *cough* may be better off with HPPD having affected out lives vs. death or the other few awful outcomes that accompany substance abuse. How are the Visual symptoms? Do I still have the same visual symptoms? Generally, the symptoms do reduce with time. I do take clonazepam, but admittedly I am unable to honestly say if it has caused me more trouble than if I had not started taking it. I think there is a place for benzodiazepines, and a meta-analytical look at posts on this message board could yield an interesting paper or an easily designed research project could shed light on some empirical data on this question. For me, it was the thick static (a severity that I saw figures and cartoons in the spinning pinwheels of the static when I closed my eyes) that prevented me from driving at night and my night vision made looking at the sky impossible and all but the brightest stars and planets would be distinguishable. The purple afterimages at night would take over my vision if I stared off into space. It would be followed by a neon green "veins" in the shape similar or = to Kluver shapes. I can tell you that during times when I did not have access to Klonopin, the anxiety and body feelings are far worse than the visuals, but the visuals are worse as I would expect because in a withdrawal the brain has not had a chance to adapt to the normal receptors. However, my vision would only be an issue at times it would be for any person with or without HPPD when they would be more aware of their vision (e.g. driving at night on a two-lane road with oncoming lights, staying up too long or looking through a telescope. Excessive glare.) my symptoms have not changed. Truthfully, they are worse, but (NO PANIC) I am certain they are the result of my vision actually getting worse and I need glasses. But, I have been putting off going to get my eyes checked. Iff in one month I haven't made the appointment and can report to anyone about it, please call me out on it. Right now, I have trouble with street signs, reading text close up and my vision was impossible to determine a "number" when I was last tested in 2004 because of the visual issues, and I make sure to take my medication before getting my eyes tested for when driving (and at least I pass these for now). (I have a lot to say, so I will try and stay on topic the best I can, but you wil get more than you asked as a result.) Perception of our environment is one of the strangest and most interesting parts of PSYCHOLOGY that I know. I can go a few days without my symptoms becoming a thought that reaches my conscious awareness. So, did I see haloes, walls move, and other visuals during those few days? I would say I saw them just as much as I was consciously aware of the birds chirping around me (they do all the time, but how often do you notice them?) that I had absolutely no real recollection of. We can attend to only so many things, so if I am having sex then I can tell you with 100% certainty that at this point I don't think about HPPD during or after! When I am writing on this message board, I can write for a few hours and talk about the symptoms but not be occupied by my own. However, just as I can now -- I look away at the wall and I see the monitor after image, the wall is moving upwards, everything is still in ghosted vision, Haloes and afterimages follow everything I see -- have these visuals they do not cause me distress. I am more concerned for those who are going to get HPPD and for the individuals who received it only after a few uses and for the people where other disorders interact with the mechanisms of HPPD to make it more difficult to accept that I am my own. In general, I know people in almost every class of profession and life but notably, none are jet pilots or dentists and also not aware of any of us being a military sniper, and these others where perfect eye-sight is required are doing very well in their lives. When they are not, the cause is usually linked to anxiety and depression that exist with HPPD and experiences of depersonalization or the visuals staying distressful can be an issue without addressing the other disorders. I have ADHD (which is finally getting research to support it as a biological brain disease, so I don't need to validate it but I am 38, have 4 papers in medical journals but live in my family's basement) which is the reason I have been gone so long. I designed the PHP front-end and MySQL backend for the Depersonalization research with Dr. Simeon in a hyperfocused binge and I designed and published research because either I was illicitly taking or finally prescribed Adderall to provide me the ability to complete a task). I also have a "lasting disorder" but it is "cured" which is my right leg's tibia (shin) had a complete spiral fracture and fibula broken like twigs and I almost required amputation, but instead, they used a scalpel to start a 25cm or so cut along my calf and then used surgical scissors and cut through my fascia to prevent compartment syndrome, put a rod through my knee cap down to my ankle and screwed my leg together and I had to wear a wound vacuum 24/7 for 4 or so months until the wound reduced dramatically in size (three times a week I would have the sponge changed by specialists) and then I could get a skin graft to be the fine leg they saved. I was very lucky. However, It causes awful restless leg symptoms (all of the little nerves slowly coming back, and a lot of feeling still doesn't exist on that area of the skin that is a giant scar) and standing for a day will cause me to feel like my knee is locking up, I can't go up and down stairs without using my arms in that case and I have to rest for a day (I can manage the pain if I am not moving, but if it gets too bad I do take tramadol and I will take it to sleep). Before this, I was taking 10-20mg Oxycodone every4-6 hours including when I would suddenly awake as it wore off. Eventually, I asked to step down and I am only telling this story because I am an Addict, and telling your doctor to reduce your narcotics is something I am proud of. However, I am still taking a combination of meds that we were reducing in small steps (until my father was diagnosed with brain cancer and so far we haven't decided it is good to rock the boat) that a substance abuser would consider a dream to have each month: d-Amphetamine, Clonazepam, Tramadol but I can promise my opinion of these are completely different. Do I still forget my keys and it has been over 2 months and I have yet to get a replacement to my driverse license I lost somewhere? Yes. However, I did keep excellent records and cared for my sick father in a way that I managed his medications, condition where nobody would have said I was inattentive. It is just how my brain attends to things, so like HPPD it is part of my biological situation (but we can learn to adapt and even take advantage of some of the things. If hearing 1000+ stories from people with HPPD makes me an expert on the topic, then I can tell just from your last sentence tells you already understand our best defense. Humans are generally very resilient and adapt to a lot of weird conditions. I will may not have daily leg pain, but I still have a titanium rod and I wouldn't try competition cycling, and I can't finish a book until I started taking meds so I can function in our world and did I overcome ADHD? I am getting closer, but as my psychiatrist said, "Your brain is special. That is all you will get for my diagnosis on you. I fill out numbers for your insurance." So, in my opinion, you are going to do fine. Very early on, about 1 year into it I was going to stop looking for my own cure and worrying if it will go away, and it enabled me the freedom to study it and observe it without excessive bias towards seeking a magic bullet cure and be realistic about what the challenge will be. Your only real limit is not landing jets on aircraft carriers at night. - dk
  11. There is news. I can't explain yet, but in short, my biggest barrier to work no longer is an issue. I will have a re-introduction post, I will cover some of that there. I have a plan. This is an image of the message board for HPPD that I was running on a server and we were pretty active.
  12. Sadly, to be honest, I am in the same position looking for a position as a research assistant.
  13. Right here. Break time is over. My ADHD is becoming increasingly better managed. I lost my father, but this allows for a lot of powerful changes to happen and to do them with the best of intentions. Yes, I do have research ideas. No, I don't have a cure I have been hiding. No, I did not read any e-mail in the last 2 years with the exception of one I was explicitly expecting, so I am backing up hard copies and then wiping all of my mail and other areas clean, starting my design and plans for building my own Tiny Home with Support Room (So, I can travel to Burning Man or other areas around the Country to set up Mobile HPPD research/information centers.). I have a verified Youtube Channel. I will be making use of this wonderful way of sending messages. I will also be working with other non-profit for projects with HPPD. Best wishes! David
  14. NODID.org is now back in my hands. It means very little in the big picture, but a small celebration. I registered NODID.ORG when we formed the National Organization for Drug-induced Disorders, Inc., a 501(c)(3) non-profit public charity. I lost the domain name, which suddenly jumped to $600 and was owned by various other groups. NODID, the organization is no longer active, but I have accounts that use dkozin@nodid.org as an e-mail back-up that should allow me to enter places to enter other sites. Admins: E-mail david.s.kozin@gmail.com with any financial issues and current SITREP. I contacted some of the larger sites to fix their links, which explains some drain on the the site, and I may have a donor that will pay for hosting. I am having a significant family issue that may result in a slow response, but much more quickly than never. If you are interested in learning about the history of the hppdonline.com web site, you can go to wayback machine and look at nodid.org and hppdonline.com and see what I was working on at different stages and can get some interesting information. Here are images from the history of HPPDonline and one from NODID. The oldest record in 1991. - David
  15. I remember feeling so protective about the HPPD community (I was married to one) that if someone pointed out ignorant comments referring to us as malingers and faking the symptoms for different reasons. My favorite were provided on a few occasions when people claimed that Dr. Abraham and DEA created HPPD as a lie and eventually I knew I was doing something right too when I was named as a co-conspirator. Usually, it was a pretty rational person selectively processing facts and emotions and they are very hard to discredit because they feel they would be aware of this disorder if it existed. I argued with a professor from Germany who read almost all of the material on LSD that one would ever need to, and for years on the Internet in email, he would only give me credit for being so open to alternative explanations. I later met the researcher who still would not believe me 100%, but he said that my willingness to identify alternatives but state something you can't deny: "Well, we have web stats that prove at least there is a trend worth considering." He later published a case report of an individual getting HPPD after mushrooms or MDMA. I used to spar against a pro-drug advocate long ago on his website after a rather in-your-face member of HPPDonline.com would return back telling me all of the lies this person is saying and what he is calling us. So, I would write in his territory (mid/early 2000's maybe?) on his site. and I used the same honest answers and stated that I do not have an answer to many of the common questions about the definitions of a disorder, but he disliked that I could attack his logical fallacies in not considering HPPD to be possible, This was occurring on his web site's personal forum. A year or so later, a lot of things changed in the HPPD landscape (I was designing my first research experiment with Dr. Simeon) and I was drawn into another chance to go spar with his anti-HPPD crap because his followers were getting bad information. He did piss me off because, well to be honest, we were both punks with a sense of self-righteousness for our stance, but I think I had a better one. However, I just agreed with him that his points could be valid in his perceptual reality, and I understood he would feel these things and was happy that he did not have to know HPPD. Then slander, but I ignored it. However, interesting that it was almost 15 years ago and I am writing about it and can remember it. I can tell you that the most HPPD friendly researcher in this community didn't know HPPD existed and was shocked to see how much literature existed, then people in the comment section will not either. I realized it was a waste of my time and I should focus on the bigger issues. In the end, I can find references to this user only on user reports from 2000-2007 on Erowid.org and his personal site is defunct. The Erowids are very supportive. This young guy annoyed me, and when I let it go I made friends with the people on that side who were open to or completely accepted HPPD as reality. I am removing excess to start over to deal with the things that do matter. That guy must have moved on or in prison or maybe here, but I know that his followers were going to do whatever they were going to do, and the other member talking about their HPPD was just as effective as me. t didn't matter what they said because I remember telling my friend during the a 7th hour of an LSD trip, "Wouldn't it be awesome if you just saw the world like this, but were not tripping?" It was only a month or so until my HPPD started. The Universe wasn't going to be subtle. I include on my Google + page the response to what my bragging rights could be for: Dr. James Faddiman asked me (unsolicited) to be his LinkedIn pal and when I asked him why me? He said, "I am a serious admirer of your work." If a pro-psychadelic member of a site heard that was true, then if the are educated psychonauts they would hear the mic just drop. Thanks for letting me steal your thread. - dk (I don't edit my posts before clicking send because I have a million things going on in my head, and I am usually hitting "send" because I get a reminder how late it is. ) Ut us 3:23 AM, and I have stuff to sell online and get real sleep. But, I spent a few hours looking at the analytics from this site over the last few years (I do have it, the comprehensive ones), and my mind was racing. I'll try to focus writing earlier, so I can check it over to create sentences and stucture that form a cohesive unit linked to the sentences around it. )