As i've discussed several times before, I use a 4 days on, 3 days off benzo treatment with 10 days off every 2-3 months to further clean the system. It has worked for 7 years now, without any sign of tolerance or withdrawal. I tweak "the recipe" a fair bit, this is my current system:
Lorazepam (2.5mg) - Thursday 6pm
Clonazepam (1mg) - Friday 9am
Clonazepam (1mg) - Saturday 9am
Lorazepam (2.5mg) - Sunday 9am
INTRODUCTION TO PHARMOKINETICS (With Specifics for the United States FDA rules and regulations)
The half-life of Klonopin averages 40hrs. So, on day 4 you still have 50% of the dose you took 2 days prior in your system. 80% of the day prior. The value obtained with humans for available active clonazepam is a 3.3 fold increase from your daily dose.
So, if you are taking 1mg/daily you achieve a steady state dose of 3.30mg.
If you are taking 4mg/daily you reach 13.2mg.
If you are taking .5mg a day, the steady dose = 1.65mg
I created a calculator you can enter in a dose and it will calculate your body dose equivalency for 7 days. It is a google doc, I am pretty sure I locked the formulas, so only change the one value and press enter and it will change automatically for you.
Another very simple way to achieve the same thing is to take your daily dose and multiply by 3.3 or even more quickly by 3.
This is a quick way to see why recommendations are for lower dose ranges.
Dose Daily Effective Dose Potency at 7 Days
Typically, these are measured in nanograms per milliliter. This is only for clonazepam, and the half-life of a 2mg dose in a 2003 study was approximately 39 hour +/- 9 hours. Use of antacids can affect this number, liver function, kidney function and food.
The average difference in C(max) and AUC between generic and innovator products was 4.35% and 3.56%, respectively. In addition, in nearly 98% of the bioequivalence studies conducted during this period, the generic product AUC differed from that of the innovator product by less than 10%.
It also explains why having a day or so lapses in a Klonopin script are infinitely easier to handle than a Xanax script. Because the drop in concentration takes the same reduction, but Xanax half life is 11.2 hours.
Klonopin Dose Calculations (Rough Estimations)
I would discuss these with your doctor, and I also call them rough because other medications can potentiate the level or medications or supplements may occupy the enzyme in the liver that break down Klonopin, so it stays in the system longer. There are many variables, but this is a good general demonstration.