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  1. K.B.Fante

    Possible relation in PAWS and HPPD?

    Just because you get symptoms slowly doesn't mean it isn't neurodegeneration. Many neurodegenerative diseases like Alzheimer's and Parkinson's come on slowly over the course of years and even decades. Last week a member of this forum posted a link to the first published study I'm aware of that proved hallucinogens can be neurotoxic: https://www.researchgate.net/publication/14821234_Degeneration_of_Purkinje_cells_in_parasagittal_zones_of_the_cerebellar_vermin_after_treatment_with_Ibogaine_or_harmaline So we now know hallucinogens have the ability to cause necrosis, aka cell death. In addition, we also know many people who get HPPD suffer from anxiety. Science has confirmed that with increased stress follows increased cortisol which creates a surplus of the transmitter glutamate: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181836/ In addition, we know glutamate produces free radicals which attack and kill brain cells: https://link.springer.com/article/10.1134%2FS000635090905011X But glutamate is also excitotoxic, activating and killing NMDA receptors, which are the same receptors targeted in certain hallucinogenic drugs: https://www.sciencedaily.com/terms/excitotoxicity.htm Finally, it's thought glutamate is the missing link to signal necrosis after ischemia (loss of oxygen) wherein during even a very brief episode of blood loss glutamate is activated and thus triggers cell death: http://www.sciencedirect.com/science/article/pii/S0301008213001305 On the topic of blood flow, it's also been noted how LSD and other hallucinogens can decrease blood circulation in certain parts of the brain: http://www.nature.com/news/brain-scans-reveal-how-lsd-affects-consciousness-1.19727 I'm just saying, between anxiety and chemical drugs there's plenty of potential for excess glutamate, loss of blood flow and a possible triggering of necrosis. When I saw a neurologist this past winter he said he didn't know what happened to me but that I had symptoms of a stroke. I also know that in the weeks leading up to taking LSD I had a period of extreme anxiety where I didn't hardly sleep for about 10 days. It was without question the worst acute stretch of anxiety I've ever had. So for me there almost had to be some sort of a glutamate overload, and I assume for those who suffered from anxiety already prior to taking drugs or had a really bad trip that triggered an incredible release of anxiety and glutamate there's a good chance they were in the same boat as I was.
    1 Points
  2. Jay1

    Advice?

    No need to quit, but just moderate it. Glad to hear you are veg... i'm vegan (I still eat doritos and oreos here and there though)
    1 Points
  3. Jay1

    Advice?

    Bad food, eg, alot of junk food, processed garbage with too much sugar and salt. I found that fixing the things i could, like my physical health, helped me to start fixing some parts of my mental health too...
    1 Points
  4. hppdonli

    NODID and HPPDonline History

    NODID.org is now back in my hands. It means very little in the big picture, but a small celebration. I registered NODID.ORG when we formed the National Organization for Drug-induced Disorders, Inc., a 501(c)(3) non-profit public charity. I lost the domain name, which suddenly jumped to $600 and was owned by various other groups. NODID, the organization is no longer active, but I have accounts that use dkozin@nodid.org as an e-mail back-up that should allow me to enter places to enter other sites. Admins: E-mail david.s.kozin@gmail.com with any financial issues and current SITREP. I contacted some of the larger sites to fix their links, which explains some drain on the the site, and I may have a donor that will pay for hosting. I am having a significant family issue that may result in a slow response, but much more quickly than never. If you are interested in learning about the history of the hppdonline.com web site, you can go to wayback machine and look at nodid.org and hppdonline.com and see what I was working on at different stages and can get some interesting information. Here are images from the history of HPPDonline and one from NODID. The oldest record in 1991. - David
    1 Points
  5. Jay1

    Advice?

    It sounds like you are doing alot of things right... Going sober is 100% the way to go and telling your mum was a smart move, even if she is having a hard time understanding... At least she knows if you want to start heading down the medication route. Have you tried cutting other things out, like caffeine? bad food? anything else causing you stress? have you tried exercise? How did you get hppd?
    1 Points
  6. K.B.Fante

    Anxiety or HPPD?

    You definitely have HPPD symptoms. When I first got this I also felt extreme exhaustion. I could hardly stay awake and even everyday tasks like completing a sentence and making lunch were difficult. I think that's the result of large-scale neurodegeneration to be honest. Looking back I also think I got my HPPD from a synthetic... The only thing you can do now is take all the steps possible to heal your brain. There's plenty of advise all over this forum, so you might wanna sit down and do some reading.
    1 Points
  7. Well guys, its a sad day, because here is pretty much the nail in the coffin that hallucinogenic use does in fact like I theorized produce an excitotoxic effect, resulting in loss of neurons. Finding this article was difficult for even me to read because it really sinks in the reality of the situation of HPPD. The good news is, believe it or not, that this still is a curable disease. More so than others, or has a better potential outcome. The reason being for this is that central nervous system tissue damage, like this, or in the case of a stroke or paralysis, does not form any scar tissue, so healing remains only to just stimulating neuronal growth. The only detriment I see to this is by possibility that the purkinje cells in the heart are also reduced, in which case I would assume fills with scar tissue rendering that area much more difficult to remedy, and possibly... impossible, which could have great consequences in the case that they send any signals to the brain that modern science is unaware of. Anyways, here it is. Abstract The indole alkaloids ibogaine and harmaline are beta-carboline derivatives that cause both hallucinations and tremor. Reports that ibogaine may have potent anti-addictive properties have led to initiatives that it be tested for the treatment of opiate and cocaine addiction. In this study, ibogaine-treated rats were analysed for evidence of neurotoxic effects because human clinical trials of ibogaine have been proposed. We recently found that ibogaine induces a marked glial reaction in the cerebellum with activated astrocytes and microglia aligned in parasagittal stripes within the vermis. Based on those findings, the present study was conducted to investigate whether ibogaine may cause neuronal injury or degeneration. The results demonstrate that, after treatment with ibogaine or harmaline, a subset of Purkinje cells in the vermis degenerates. We observed a loss of the neuronal proteins microtubule-associated protein 2 and calbindin co-extensive with loss of Nissl-stained Purkinje cell bodies. Argyrophilic staining of Purkinje cell bodies, dendrites and axons was obtained with the Gallyas reduced silver method for degenerating neurons. Degenerating neurons were confined to narrow parasagittal stripes within the vermis. We conclude that both ibogaine and harmaline have selective neurotoxic effects which lead to degeneration of Purkinje cells in the cerebellar vermis. The longitudinal stripes of neuronal damage may be related to the parasagittal organization of the olivocerebellar climbing fiber projection. Since these drugs produce sustained activation of inferior olivary neurons, we hypothesize that release of an excitatory amino acid from climbing fiber synaptic terminals may lead to excitotoxic degeneration of Purkinje cells. https://www.researchgate.net/publication/14821234_Degeneration_of_Purkinje_cells_in_parasagittal_zones_of_the_cerebellar_vermin_after_treatment_with_Ibogaine_or_harmaline
    1 Points
  8. K.B.Fante

    New video on HPPD

    This was only posted a week ago: What always amazes me is the comments section, reading people who say HPPD is fun and they enjoy it. I'm happy to swap them their mild HPPD for my severe HPPD and DP-DR and see how much fun they have!
    1 Points