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http://psychedelic-i...sensory-Binding This article had some very interesting info on how the 5ht2a receptor is involved in visual framerate, edge detection, peripheral vision, but also depersonalization and other dream-like states. Just eyed through it but I'll read the whole article soon. "There is evidence that 5-HT2A agonists lead to lateral disinhibition in the cortex by blocking presynaptic uptake of 5-HT at the lateral inhibitory synapse, or by overriding tonic GABAB inhibitory postsynaptic potentials (IPSPs) with asynchronous ESPCs at the lateral-inhibitory synapse.21,22 Loss of inhibition at the lateral synapses in columns of the visual cortex would lead directly to shifting and wiggling in peripheral line, texture, and contrast resolution." http://jp.physoc.org/content/539/1/223.full.pdf I also eyed through this article regarding dopamine and vision. Interesting as well! "The visual system is equipped with a separate dopaminergic system which modifies lateral interactions within the retina during the course of light/dark adaptation (Weiler et al. 2000)." This would explain a bit why many with HPPD have so bad reactions to serotonin agonists+antagonists (boosting the dysregulation), good reactions to benzos and anti-eps (increased inhibition), but also why many dopamine agonists can help some of the HPPD-symptoms (photosensitivity and poor working-memory in particular). Here is the Dr. Abrahams list of HPPD symptoms. http://www.dpselfhel...order-aka-hppd/ We might be on the verge of cracking the HPPD mystery, Visual!