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Hallucinogen Persisting Perception Disorder (HPPD) Support Forum

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  1. Today
  2. I really want to stop seeing the patterns. I will give risperidone a shot
  3. This is a very important question for me. We all know that antipsychotics can make VS Symptoms worse. I dont have Visual Snow Syndrome symptoms. I am suffering from bad trip LSD visuals. I see patterns on the surface of objects. So could antipsychotics be useful for my HPPD? I doubt that antipsychotics can make hallucinations worse. But has anyone experience with that? Thank you very much.
  4. https://www.google.com/amp/s/healthtalk.unchealthcare.org/this-is-lsd-attached-to-a-brain-cell-serotonin-receptor/amp/ https://www.google.com/amp/s/www.zmescience.com/science/news-science/lsd-stuck-brain-20022017/amp/
  5. https://www.google.com/amp/s/www.zmescience.com/science/news-science/lsd-stuck-brain-20022017/amp/
  6. https://www.google.com/amp/s/www.zmescience.com/science/news-science/lsd-stuck-brain-20022017/amp/ https://www.google.com/amp/s/healthtalk.unchealthcare.org/this-is-lsd-attached-to-a-brain-cell-serotonin-receptor/amp/ They are suggesting that LSD actually get stuck inside your cells. Is protein fasting and autophagy (self-eating) a cure for HPPD?
  7. Yesterday
  8. No risperidone. I've also been on Mirtazapine (4 yrs) and Zopiclone (6 months). Quit everything back in Jan-Feb after my symptoms turned to worse. Withdrawal from bith meds definitely exaggerated symptoms for a while, and I was off them completely for 5 months. Some symptoms improved after a while, like I mentioned (light sensitivity, dp/dr, also palinopsia got slightly better, was having constant positive afterimages but it was reduced by 50%) but the others have kept on deteriorating (visual snow, tinnitus, halos, starbursts, bfep, pattern glare). I got sleeping issues again after five months (in July) and have since then been back on Zopiclone, lower dose though, and my psychiatrist convinced I should get back on a low dose of Mirtazapine too, and I hate myself that I've done that, because it feels like symptoms have progressed faster since then. But it could just be correlation. Not sure of anything anymore. Now I am trying to get off Mz again, and it may be the cause of some symptoms getting a lot worse past two weeks. I started tapering off 17 days ago, when my tinnitus had already gotten worse. Now it's a lot worse plus the hyperacusis, and today I also started to notice increased palinopsia and diplopia, which hasn't happened since January. Personally I suspect there are a lot of reasons for my deteriorating condition. It's not only drugs, since I've been off them before I even got visual snow. I suspect it is a combination of drugs, pharmaceuticals and infection, and the neuro borreliosis back in 2008 has been the main kicker.
  9. As far as I know its pretty useful for epileptics. Granted if these alternative theories are wrong, then its discordance/desyncronization in the feedback loops involved due to white matter neuronal loss, which would be for the most part unrepairable even with neurogenesis. It is a very curious thing though that Risperidone is working in some of these patients...
  10. Hi Katkat. My names Ben, pleased to connect. I am currently on the Gold Coast AUS and in frequent contact with Professor McConnell and Hope1. I will be participating in the study in Sydney. I would love to DM you and have a Talk. Look forward to connecting soon.
  11. Last week
  12. In some cases it does appear risperidone makes symptoms worse. Maybe an antagonist would be better. EDIT: Antagonists like trazodone seem to do nothing, but I was thinking that maybe its nessasary to have a highly specific 5HT2A inverse agonist.
  13. I was put on 200mg Lamotrigine beginning of 2018, when I was diagnosed with bipolar disorder. It was shortly after that that I saw visual snow for the first time. I even brought this up with the prescribing doctor. At this point I had no idea even what visual snow was. Visual snow got worse during the year, end of 2018 I also had tinnitus and diplopia. Jan 2019 I started to see the visual snow in day time, and I also got palinopsia, light sensitivity, floaters, starbursts, halos, etc. I quit the treatment with Lamitrogine in February. No change. Instead most of my symptoms (except light sensitivity and dp/dr) have been progressing and getting worse since then, and this far nothing I've done has changed that. Quitting all drugs and pharmaceuticals, caffeine, nicotine has had zero effect. Ketogenic diet during six months and intermittent fasting during five months has had zero effect. Living healthy, excercise, meditation has made no change in the progression of the symptoms. I am ready to try keppra and clonazepam on top of the infection approach, since I am far from convinced infection is the cause, but I got to try something, because as it is... I am slowly deteriorating.
  14. Here is another case where the patient is prescribed 1mg of risperidone, and within two months reports that they are cured. Ill post more if I find any. Looks like one month in though they discontinued Risperidone and added the lamotrigine. This is the lamotrigine person I mentioned in the previous post. Also if anyone has had any EEGs done please do post the results. Would like to add too that its possible that the Risperidone could exasperate symptoms initially, but then resolve them, sometimes in medicine when there is a cure, the symptoms get worse before better. Not always, but there are cases. Heres a post from another member, stating that it worsened his symptoms, he doesn't give the dose that he was prescribed though unfortunately. Posted December 29, 2012 Firstly they gave me risperidone, this amplified my symptoms and i stopped taking them. They then gave me amisulpride, that didnt go well either. Then seroquel, it was the better of the three.Once i got used to the side effects it doesnt seem so bad, although im really not sure how much good its doing me. Thats pretty much all I could find on the forum, if theres anything else anyone can find please share. Thanks! If all this is true and accurate, these desyncronization or discordances in the brain could be the cause of a lot of mental disorders.
  15. Yeah, i'm very lucky to have it mild enough it's not impairing. My thing is, i love my visuals because they make looking at the most pedestrian things so PRETTY IMO, just looking at the floor at my messy fast food job makes the place look like confetti. if i'm not facing the sun i'd still see them, it's mostly just in whatever section of my vision it's in, it's just /usually/ in the sky, but not necessarily
  16. Treatment with the atypical antipsychotic medications paliperidone and risperidone normalized basal extracellular glutamate https://www.ncbi.nlm.nih.gov/pubmed/21699956 In line with my other post
  17. HUGE post today. Last night I was reading an LSD study and the effects on the brain, going on about areas that are upreg/downreg or something. Anyways the down regulated areas he mentioned are desyncronized. I had to look up what that meant because I had no idea, but it started going on about brain frequencies etc. Basically the neurons in areas pulse with a feed back loop from other areas through resonance, the neurons fire in waves, as groups, its exactly what I was talking about really early on in my first thread. So I started conjecturing that maybe in a few minor users of hallucinogens their brain becomes permanently desynced so to speak, or the harmony between the two areas become discordant, exactly like I used to conjecture, only now there is physical evidence to the idea being possible. So, it comes back to the very first and original posts I made here when I joined 7-8 years ago, about using an antagonist, or maybe even an inverse agonist to "resync" the brain areas. It appears that the issues are predominately in the temporal lobes for people who have anxiety, and the occipital lobes for visual effects. I found a study involving Dr. Abraham where they did EEG studies on post drug users with and without anxiety, most of the users with anxiety showed irregularities in these areas, these are also areas in with patients with seizures can be effected. Dr. Abraham and the other doctor also mentioned how before seizures, patients will report high fear/anxiety. The condition of HPPD could very well be brother/sister relationship with epilepsy interestingly enough. Then I searched the HPPD forum for any posts involving 5HTP2A receptor antagonists or agonists. What found is shocking. Heres the posts from "Victor" Posted March 31 In my case the disorder healed in two months with risperidone and paroxetine. Paroxetine acting upon anxiety and risperidone over visual distortions. Well you know the risk of self-medicating, do not do that, I had facial spasms with only 3 days of use of quetiapine (prescribed by shrink). Doctors actually know about the disorder, but since it is something very recent and vague hardly anyone is diagnosed with it, even because sequels of psychedelic drugs are not the only reason for the cause of false visual perceptions or other senses without loss of lucidity. So go to the psychiatrist anyway, because only then will you get these medications and then heal. Other than this, physical activities are great for diverting your focus from the problem, but the visual symptoms will only disappear with treatment using remedies. I also suggest meditation and some artistic activity such as writing, drawing, playing an instrument, etc. And also temporary abolition of coffee, alcohol and cigarette consumption. Posted March 25 Hello ! Your story is very similar to everyone here, including mine. When I had HPPD, I also got the symptoms very fast and only noticed them after smoking marijuana days after my trip with LSD. What matters is that as quickly as the symptoms came, they left. This is because I did psychiatric treatment, initially using paroxetine for anxiety, risperidone for visual distortions and clonazepam for anxious seizures. Risperidone is an antipsychotic and a major antagonist of LSD as well as quetiapine and chlorpromazine (I have taken all of these, but risperidone was the most effective). In a matter of two months the false hallucinogenic perceptions were gone. With you it would not be different, but for this you need to look for a psychiatrist and explain what happens to you, as he will know the right medication to apply. Please do not self-medicate, as these medicines can have horrible adverse reactions. I for example had facial spasms when I took quetiapine (this I only took for 3 days). I recommend that you do not look for it on the internet, because it is still very vague, unfortunately it is difficult to find information about it and almost all are scary, as it comes from a sensational and anti-drug media. Rest assured, what happens to you is nothing serious and has a cure. Avoid using drugs at this time, including marijuana, alcohol, cigarettes, and coffee. Stay in peace ! If you read most of his posts he is very adamant that Risperidone cured his HPPD. I found another poster too... Posted October 26, 2013 I have HPPD consisting of marihuana-like derealization, LSD-like movements of surfaces, and optical noise. The LSD-like movements had gotten much better over the course of 7 years until they were barely noticeable, until I took Ritalin. Within two weeks, the LSD effects were almost as bad as in the beginning. The rest of my visual effects were not affected. I discontinued Ritalin. The LSD effects remained unchanged (other than going through their usual cyclical fluctuation over 5 days (IIRC) for the next few weeks. Then I started taking low-dose Risperidone (2mg, I think). For the first two days, nothing happened. On day 3, the LSD effects were basically turned off, back to barely noticeable. It was like flipping a switch. In the morning they were there, in the afternoon they were almost gone. I continued taking Risperidone for a few weeks, even increased the dosage, but nothing else happened. There was no effect on my other visuals. After discontinuing Risperidone, the LSD effects did not return, even when I started taking Ritalin again (strange, huh?). I've been taking Ritalin for a few years now. The HPPD symptoms are stable. Caffeine never affected my symptoms. I also found another poster saying he was cured by 200mg of Lamotrigine, which is an antiseizure medication, but it would be clear that this would only treat the symptoms since they are probably similar to epilepsy like disruptions in the brains resonations. Also, there are arguements that Risperidone, an inverse agonist of 5HTP2A exasperates symptoms of HPPD, which is also probably very true, as per the drug in itself without history of HPPD can cause palinopsia. I'm guessing the difference is just in the dose, as the one guy listed his dose which was very smart of him, and as far as I'm concerned is a pretty low dose, not the lowest, but pretty low, as the high does is 200mg. So the answer may very well be in inverse agonists, and maybe even antagonists as well. whichever being the case I'm not entirely sure. Interestingly enough this is probably the "reversal" that hope's research team may have in mind, whether they read my initial ideas/post in my first thread I have no idea, and if that is what they have in mind I'm not entirely sure. But this may very well be it. The cure for HPPD.
  18. I think that you're lucky to enjoy your hppd, and to have the photoshop skills to show it to the rest! If you turn around, not facing the sun, I guess they are gone? In that case, it would be shadows.
  19. To keep it more ordered, I've created a whole topic replying to that: http://hppdonline.com/topic/6791-hppd-is-not-serotonergic-in-nature/
  20. I should add the prefix to the subject: "Why I think that", but it would be too long. Consider it added. I'll elaborate some points and quote some sources, but note that many more sources can be found, the conclusion is not based on these sources only. Note that I'll make a conceptual leap: since basically nothing can be said about HPPD due to lack of research and data, I'll treat it as some form of psychosis/schizophrenia, which is widely studied (although not understood anyway), and REMARKABLY similar to HPPD. At the very least, it could be said that HPPD is a mild form of psychosis/schizophrenia, a subset, etc, but it seems very logical to assume that they will share many characteristics. See second link, about Drug Induced Psychosis - The causes of schizophrenia are not understood, and many hypothesis have been proposed, notably: serotonergic causes, dopaminergic causes, and glutamate causes. While the sertonergic idea is the older, newer studies point in other directions, mainly of stimulatory nature https://link.springer.com/chapter/10.1007/978-1-4684-8228-7_17 https://www.researchgate.net/publication/314031343_Drug_Abuse_and_Psychosis_New_Insights_into_Drug-induced_Psychosis - Recent studies have indicated the importance of the Dopaminergic system in the effects of LSD, distinguishing between phases of the LSD effects according to the main receptors activated, and proposing as a model for schizophrenia. https://www.ncbi.nlm.nih.gov/m/pubmed/21352832 https://www.ncbi.nlm.nih.gov/pubmed/15723230 - While sertonergic system is mainly associated with mood (depression, anti-depressants), the Glutamate system is more related with the information processing and memory formation. - The relationship between dopamine and glutamate is deep, and many studies are studying their link to each other, and to psychosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162342/ https://www.ncbi.nlm.nih.gov/pubmed/24524997 https://www.nature.com/articles/s41398-017-0071-9 - Going back to David Nichols study about the 2 different phases (sertonergic and dopaminergic) phases of LSD, and comparing that to the description of HPPD, seems clear that HPPD seems more "phase 2". It's usually describe as "the last part of an LSD trip" - For drugs or situations that are well known to trigger or worsen HPPD according to the community, it can be found that they act on the dopamine/glutamate system, but NOT (or barely) on the sertonergic system. -- coffee -- stress -- cocaine - The inverse argument can be seen also: drugs that act directly on the serotonergic system, usually have little effect on HPPD, or make it even worse. Example: anti-depressants (SSRI). Also, the same drugs are not known to cause HPPD. - Of the drugs that have consistently shown usefulness for the HPPD community, 2 of the 4 target the Glutamate system https://www.reddit.com/r/HPPD/comments/aqzv06/lions_manenaccholinemagnesium/ - Some HPPD sufferers are experimenting with Ketamine, with good results. Ketamine's main method of action is through the Glutamate system, not serotonin. - Regarding stress being a trigger for HPPD, the relationship between cortisol and glutamate and PTSD has been already treated, in this example, by no less than David Nutt, one of the most world renowned scientists regarding drugs: https://www.ncbi.nlm.nih.gov/pubmed/18701640 - More about the relationship of psychedelics, anti-psychotics, and 5HT2A and Glutamate receptors can be seen here: http://blogs.discovermagazine.com/neuroskeptic/2011/12/03/a-psychedelic-tale-of-two-neurotransmitters/#.XaWgWHj5WHs - More on the relationship of excess glutamate in the PFC and schizophrenia: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107933/ https://www.ncbi.nlm.nih.gov/pubmed/16860780/ - Chronic LSD, schizophrenia, glutamate, etc: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110609/ In sum, for all of the above, I believe it's pretty clear that HPPD has way bigger chances of being glutamate related, than serotonin related. I could also keep going on a bit more about in the hypothesis, but I'll leave that for a follow up text. Looking forward to reading all opinions. Cheers!
  21. So glad to hear that people are interested in participating. If you don't wish to comment and you are interested, feel free to message me!
  22. The NNRF research study for HPPD is open to 50 confirmed cases of the disorder which will be conducted in Sydney Australia. Interested parties can submit their information here: info@neurogroup.org
  23. I am feeling really really good when I am on keppra. I take 250mg when I wake up and it knocks out my DP completely. It also kills the brain fog. I noticed a 30% reduction in CEVs so far. When Keppra starts to wear off I notice an increase in DP. I Guess I have to take the second pill earlier. I am on 500mg and I will add 250mg every 2 weeks until I reach 2000mg or when I will start noticing side effects. So far I dont notice any side effects anymore unless feeling awesome is a side effect. I have hppd for only 3 months. I think with enough time, healthy lifestyle(keto) and the keppra treatment it can go away completely.
  24. I use Ashwagandha since a few weeks back. Really helps me with both falling asleep and deep sleep, but will probably have to agree with the above statement, slight increase in withdrawal symptoms (I am tapering off Zopiclone currently). Haven't noticed any change in other HPPD symptoms.
  25. My dad has tinnitus. My mom has anxiety and depression. They've never done drugs. My sister gets visual snow when rubbing her eyes (but I guess that's not completely unnormal after psychedelics use).
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